Hydatidiform Mole: Background, Pathophysiology, Epidemiology | Hydatidiform mole

A hydatidiform mole is considered malignant if metastases or destructive invasion of the myometrium (ie, invasive mole) occurs, or when the ...ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoEdition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSLogInSignUpIt'sFree!Edition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSRegisterLogInNoResultsNoResultsForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoclosePleaseconfirmthatyouwouldliketologoutofMedscape.Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit.LogoutCancelhttps://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjU0NjU3LW92ZXJ2aWV3processing....Drugs&Diseases>Obstetrics&GynecologyHydatidiformMoleUpdated:Feb16,2018Author:LisaEMoore,MD,MS,FACOG,RDMS;ChiefEditor:WarnerKHuh,MD more...ShareEmailPrintFeedbackCloseFacebookTwitterLinkedInGoogle+SectionsHydatidiformMoleSectionsHydatidiformMoleOverviewBackgroundPathophysiologyEpidemiologyPrognosisPatientEducationShowAllPresentationHistoryPhysicalExaminationShowAllDDxWorkupLaboratoryStudiesImagingStudiesHistologicFindingsShowAllTreatmentMedicalCareSurgicalCareLong-TermMonitoringShowAllMedicationQuestions&AnswersMediaGalleryReferencesOverviewBackgroundGestationaltrophoblasticdiseaseencompassesseveraldiseaseprocessesthatoriginateintheplacenta.Theseincludecompleteandpartialmoles,placentalsitetrophoblastictumors,choriocarcinomas,andinvasivemoles. Adietdeficientinanimalfatandcarotenemaybeariskfactor.[1] Morerecently,JapaneseinvestigatorshaveidentifiedanovelhomozygousnonsensemutationintheNLRP7gene (c.584G>A;p.W195X)inapatient thatappearstoassociatedwithrecurrenthydatidiformmole.[2]Theyalsonotedthatthemolewasbiparental,andtherewasaspecificmaternallossofDNAmethylationof differentiallymethylatedregions(DMRs).[2]Almostallwomenwithmalignantgestationaltrophoblasticdiseasecanbecuredwithpreservationofreproductivefunction.Thefollowingdiscussionislimitedtohydatidifo


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