May2001-Volume23-Issue5PreviousArticleNextArticleArticleasEPUBExportAllImagestoPowerPointFileAddtoMyFavoritesColleague'sE-mailisInvalidYourName:(optional)YourEmail:Colleague'sEmail:Separatemultiplee-mailswitha(;).Message:Thoughtyoumightappreciatethisitem(s)IsawatEmergencyMedicineNews.SendacopytoyouremailYourmessagehasbeensuccessfullysenttoyourcolleague.Someerrorhasoccurredwhileprocessingyourrequest.Pleasetryaftersometime.EndNoteProciteReferenceManagerSavemyselectionINFOCUSRoberts,JamesR.MDAuthorInformationDr.RobertsisthechairmanofthedepartmentofemergencymedicineandthedirectorofthedivisionoftoxicologyatMercyHealthSystemsandaprofessorofemergencymedicineandtoxicologyatDrexelUniversitySchoolofMedicine/TheMedicalCollegeofPA/HahnemannUniversityinPhiladelphia.AcompendiumofDr.JamesRoberts'InFocuscolumnsisavailableinbookform.The302-pagevolume,InFocus:Roberts'PracticalGuidetoCommonMedicalEmergencies,isavailablefromLippincottWilliams&Wilkinsfor$49.95bycalling(800)638-3030.EmergencyMedicineNews:May2001-Volume23-Issue5-p8,10,13doi:10.1097/01.EEM.0000288653.35375.62MetricsAbstractTherearenumerousserologicteststodiagnoseEpsteinBarrvirusmononucleosis,butlaboratorytestingisnotasstraightforwardasonemightsuspectEverypatientwithasorethroatdoesnotneedathroatculture,CBC,orASOtitertest,nordoeseverypatientwiththesesymptomsandanoccasionalerrantlymphnodeneedaworkupforinfectiousmononucleosis.Whenanemergencyclinicianisfacedwithsomespecificscenarios,testingfortheEpsteinBarrvirusseemsappropriate.Laboratorytestingforinfectiousmononucleosisissomewhatcomplicated,andtobeacademicinsomecases,thework-upinvolvesmorethanjustorderingamonospottest.TherearecurrentlynumerousserologicteststodiagnoseEpsteinBarrvirusmononucleosis,andasurfeitofinvestigationstodiagnoseotherviraletiologies.Inshort,laboratorytestingisnotasstraightforwardasonemightsuspect.Manynascentinfectionswillescapelaboratorydetectionaltogetherunlesstheclinicianisawareofthelimitationsoftheclinicallaboratory.DiagnosisofEpstein-BarrVirus-relatedDi

Other infections that produce these antibodies create lower antibody levels than those by the Epstein-Barr virus. In their simplest form, heterophile antibody-type ...September2003-Volume25-Issue9PreviousArticleNextArticleArticleasEPUBExportAllImagestoPowerPointFileAddtoMyFavoritesColleague'sE-mailisInvalidYourName:(optional)YourEmail:Colleague'sEmail:Separatemultiplee-mailswitha(;).Message:Thoughtyoumightappreciatethisitem(s)IsawatEmergencyMedicineNews.SendacopytoyouremailYourmessagehasbeensuccessfullysenttoyourcolleague.Someerrorhasoccurredwhileprocessingyourrequest.Pleasetryaftersometime.EndNoteProciteReferenceManagerSavemyselectionPediatricRounds:Part3inaSeriesKing,BrentR.MDAuthorInformationDr.Kingisanassociateprofessorofemergencymedicineandpediatrics,andthechairmanofthedepartmentofemergencymedicineattheUniversityofTexasHoustonMedicalSchool.ArashfollowingtreatmentwithamoxicillininanadolescentisevidencethattheactualdiagnosisismononucleosisEmergencyMedicineNews:September2003-Volume25-Issue9-p15,18Rashescanbeassociatedwithinfectiousmononucleosis,andthelikelihoodofrashincreasesgreatlyforpatientswithinfectiousmononucleosiswhoreceiveampicillinoramoxicillin.Therashisgenerallydescribedasanerythematousmaculopapularexanthem,andtypicallyoccursbetweenfiveandninedaysaftertheinitiationofantibiotictreatment.Thepathophysiologyofthisrashhasnotyetbeendescribed,butitdoesnotseemtorepresentatrueallergicreaction.Intheadolescentwithapparentstreptococcalpharyngitis,arashfollowingtreatmentwithamoxicillinshouldbeconsiderdefactoevidencethattheactualdiagnosisismononucleosis.ThemostcommontestfordetectingEpstein-BarrvirususesheterophileantibodiesAlthoughrare,afewneurologicconditionshavebeenassociatedwithinfectiousmononucleosis.ThemostcommonareGuillain-Barresyndrome,cranialnervepalsies,asepticmeningitis,andmeningoencephalitis.Additionally,averyrareneuropsychiatricconditionknownasmetamorphopsiasometimesoccurs.AlsoknownastheAliceinWonderlandsyndrome,thisconditionresultsinsignificantdeficitsinpe

MononucleosisSpotTestMedicallyreviewedbyArefaCassoobhoy,MD,MPH—WrittenbytheHealthlineEditorialTeam—UpdatedonDecember16,2020MonoHowthetestworksProcedureComplicationsUnderstandingtestresultsWhatisamononucleosisspottest?Amononucleosisspot(orMonospot)testisabloodtestusedtodeterminewhetheryouhavecontractedtheEpstein-Barrvirus,thevirusthatcausesinfectiousmononucleosis.Yourdoctormayorderthistestifyouhavesymptomsofmononucleosis.Mononucleosisisaviraldiseasethataffectscertainbloodcellsandcreatesflu-likesymptoms.Whatismononucleosis?MononucleosisisaviralinfectioncausedbytheEpstein-Barrvirus(EBV),whichisatypeofherpesvirusandoneofthemostcommonhumanviruses.Alsocalled“mono”and“thekissingdisease,”theillnessisn’tconsideredseriousorlifethreatening.Thisdiseasetypicallyaffectsteenagersandyoungadultsintheir20s.Thesymptomsofinfectiousmononucleosiscanmakeitdifficulttocontinuewithnormaldailyactivities.Symptomsmaylastfromseveralweekstoacoupleofmonths.Inrarecases,itcanlastseveralmonths.Symptomsofmononucleosisinclude:feversorethroatswollenglandsinneckandarmpitsseverefatiguebodyachesheadacheslossofappetiterashswollenspleen,liver,orboth(uncommon)Ifyouhavethesesymptomsforaweekorlonger,youmayhavemono.Yourdoctormayperformthemononucleosisspottesttoconfirm(orruleout)thediagnosis.Howdoesthetestdetectthevirus?Whenavirusinfectsthebody,theimmunesystemgoestoworktofightitoff.Thisisyourbody’sprotectivereaction.Itincludesthereleaseofcertainantibodies,or“fightercells,”chargedwithgoingaftertheviralcells.Themononucleosistestlooksforthepresenceoftwoantibodiesthattypicallyformwhencertaininfections—likethosecausedbytheEpstein-Barrvirus—arepresentinthebody.Onrareoccasions,thetestmayshowantibodieseventhoughyoudon’thavetheinfection.Thismayoccurespeciallyifyouhave:hepatitisleukemiarubellasystemiclupuserythematosusotherinfectiousdiseasesandsomecancersIfthetestcomesbacknegative,itmaymeanyoudon’thavetheinfectionorthatthetestwasperformedtooearlyortoolatetodetecttheantibodies.Yourdoctormightrecommendasecondtestinacouplewee

Monospot test (heterophil test). This quick screening test detects a type of antibody (heterophil antibody) that forms during certain infections. A sample of blood is ...JumptocontentALERT:Updatedvisitorpolicyinplace7a.m.Wednesday,May26.Learnmore.OtherUMHSSitesYouarehereHome»MononucleosisTestsTopofthepageMononucleosisTestsTestOverviewMononucleosistestsarebloodteststolookforantibodiesthatindicatemononucleosis(mono),whichisusuallycausedbytheEpstein-Barrvirus(EBV).Theantibodiesaremadebytheimmunesystemtofightaninfection.Monotestsinclude:Monospottest(heterophiltest).Thisquickscreeningtestdetectsatypeofantibody(heterophilantibody)thatformsduringcertaininfections.Asampleofbloodisplacedonamicroscopeslideandmixedwithothersubstances.Ifheterophilantibodiesarepresent,thebloodclumps(agglutinates).Thisresultusuallyindicatesamonoinfection.Monospottestingcanusuallydetectantibodies2to9weeksafterapersonisinfected.Ittypicallyisnotusedtodiagnosemonothatstartedmorethan6monthsearlier.EBVantibodytest.Forthistest,asampleofbloodismixedwithasubstancethatattachestoantibodiesagainstEBV.Aseriesoftestscandetectdifferenttypesofantibodiestohelpdeterminewhetheryouwereinfectedrecentlyorsometimeinthepast.WhyItIsDoneThemonospottestisdonetohelpdiagnosearecentmonoinfection.Epstein-Barrvirus(EBV)antibodytestingisalsodonetohelpdiagnosemono.TheEBVantibodytestcanhelpdeterminewhetheryouhaveeverbeeninfectedwiththevirusandwhethertheinfectionhasbeenrecent.EBVantibodytestingisusuallydonewhenyouhavesymptomsofinfectiousmononucleosisandamonospottestresultisnegative.EBVantibodytestingmayalsobedonetocheckforantibodiestoEBVwhenapersonhasadiseaseorusesmedicinethatcausesproblemswiththeimmunesystem.HowToPrepareIngeneral,there'snothingyouhavetodobeforethistest,unlessyourdoctortellsyouto.HowItIsDoneThemonospottestisdoneonasmallsampleofbloodtakenfromyourfingertiporfromavein.TheEpstein-Barrantibodytestisdoneonabloodsampletakenfromyourvein.BloodtestfromafingerstickForafinger-sticksample,thehealthprofessionalwillpuncturetheski

One must consider that the heterophile antibody test results may be negative early in the course of EBV infectious mononucleosis. Positivity ...ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointSpecialty:MultispecialtyAllergy&ImmunologyAnesthesiologyBusinessofMedicineCardiologyCriticalCareDermatologyDiabetes&EndocrinologyEmergencyMedicineFamilyMedicineGastroenterologyGeneralSurgeryHematology-OncologyHIV/AIDSHospitalMedicineInfectiousDiseasesInternalMedicineMultispecialtyNephrologyNeurologyOb/Gyn&Women'sHealthOncologyOphthalmologyOrthopedicsPathology&LabMedicinePediatricsPlasticSurgeryPsychiatryPublicHealthPulmonaryMedicineRadiologyRheumatologyTransplantationUrologyMedicalStudentsNursesPharmacistsResidentsTodayonMedscapeEdition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSLogInSignUpIt'sFree!Edition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSRegisterLogInNoResultsNoResultsSunday,July11,2021ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointclosePleaseconfirmthatyouwouldliketologoutofMedscape.Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit.LogoutCancelhttps://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly93d3cubWVkc2NhcGUuY29tL2Fuc3dlcnMvMjIyMDQwLTIyODAxL3doaWNoLWxhYi1zdHVkaWVzLWFyZS1zcGVjaWZpYy1mb3ItZXBzdGVpbi1iYXJyLXZpcnVzLWVidi1pbmZlY3Rpb3VzLW1vbm9udWNsZW9zaXMtbW9ubw==processing....Drugs&Diseases>InfectiousDiseases>Epstein-BarrVirus(EBV)InfectiousMononucleosis(Mono)Q&AWhichlabstudiesarespecificforEpstein-Barrvirus(EBV)infectiousmononucleosis(mono)?Updated:Apr21,2021Author:KartikaShetty,MD,FACP;ChiefEditor:MichaelStuartBronze,MD more...ReferencesShareEmailPrintFeedbackCloseFacebookTwitterLinkedInGoogle+AnswerHeterophileantibodiesSinceheterophileantibodiestypicallyreturnquickerthanEBVspecificantibodies,itisthetestofchoiceinmostclinicalsettingstodetermineifanindividualhasinfectiousmononucleosis.Reactiveheterophileantibodiesinapatientwiththetypicalsymptom

In the vast majority of cases, diagnosis of infectious mononucleosis is relatively ... Performing tests for specific Epstein-Barr virus (EBV) antibodies in these cases ...Clipboard,SearchHistory,andseveralotheradvancedfeaturesaretemporarilyunavailable.SkiptomainpagecontentCOVID-19InformationPublichealthinformation(CDC)Researchinformation(NIH)SARS-CoV-2data(NCBI)Preventionandtreatmentinformation(HHS)Español AccesskeysNCBIHomepageMyNCBIHomepageMainContentMainNavigationSearch:SearchAdvancedClipboardUserGuideSaveEmailSendtoClipboardMyBibliographyCollectionsCitationmanagerDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSavecitationtofileFormat:Summary(text)PubMedPMIDAbstract(text)CSVCreatefileCancelEmailcitationSubject:1selecteditem:3027679-PubMedTo:Format:SummarySummary(text)AbstractAbstract(text)MeSHandotherdataSendemailCancelAddtoCollectionsCreateanewcollectionAddtoanexistingcollectionNameyourcollection:Namemustbelessthan100charactersChooseacollection:UnabletoloadyourcollectionduetoanerrorPleasetryagainAddCancelAddtoMyBibliographyMyBibliographyUnabletoloadyourdelegatesduetoanerrorPleasetryagainAddCancelYoursavedsearchNameofsavedsearch:Searchterms:TestsearchtermsWouldyoulikeemailupdatesofnewsearchresults?SavedSearchAlertRadioButtonsYesNoEmail:(change)Frequency:MonthlyWeeklyDailyWhichday?ThefirstSundayThefirstMondayThefirstTuesdayThefirstWednesdayThefirstThursdayThefirstFridayThefirstSaturdayThefirstdayThefirstweekdayWhichday?SundayMondayTuesdayWednesdayThursdayFridaySaturdayReportformat:SummarySummary(text)AbstractAbstract(text)PubMedSendatmost:1item5items10items20items50items100items200itemsSendevenwhentherearen'tanynewresultsOptionaltextinemail:SaveCancelCreateafileforexternalcitationmanagementsoftwareCreatefileCancelYourRSSFeedNameofRSSFeed:Numberofitemsdisplayed:510152050100CreateRSSCancelRSSLinkCopyFulltextlinksTaylor&FrancisFulltextlinksActionsCiteFavoritesDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSharePermalinkCopyPagenavigationTitle&authorsAbstrac

The mononucleosis test is used to help determine whether a person with symptoms has infectious mononucleosis (mono). The test is used to ...SkiptomaincontentMononucleosis(Mono)TestSendUsYourFeedbackChooseTopicAskaLaboratoryScientistAlsoKnownAsMononucleosisSpotTestMononuclearHeterophileTestHeterophileAntibodyTestMonospotFormalNameInfectiousMononucleosisRapidTestThisarticlewaslastreviewedonJuly21,2016.ThisarticlewaslastmodifiedonMarch24,2021.AtaGlanceWhyGetTested?Todetectandhelpdiagnoseinfectiousmononucleosis(mono)WhenToGetTested?Whenaperson,especiallyanadolescent,hassymptomsofmononucleosis,includingfever,sorethroat,swollenglands,andfatigueSampleRequired?AbloodsampledrawnfromprickingofyourfingertiporfromaveininyourarmTestPreparationNeeded?NoneLookingforTestResults?Youmaybeabletofindyourtestresultsonyourlaboratory'swebsiteorpatientportal.However,youarecurrentlyatLabTestsOnline.Youmayhavebeendirectedherebyyourlab'swebsiteinordertoprovideyouwithbackgroundinformationaboutthetest(s)youhadperformed. Youwillneedtoreturntoyourlab'swebsiteorportal,orcontactyourhealthcarepractitioner inordertoobtain yourtestresults.LabTestsOnlineisanaward-winningpatienteducationwebsiteofferinginformationonlaboratorytests.Thecontentonthesite,whichhasbeenreviewedbylaboratoryscientistsandothermedicalprofessionals, providesgeneralexplanationsofwhatresultsmightmeanforeachtestlistedonthesite,suchaswhatahighorlowvaluemightsuggesttoyourhealthcarepractitioner aboutyourhealthormedicalcondition.LookingforReferenceRanges?Thereferencerangesforyourtestscanbefoundonyourlaboratoryreport.Theyaretypicallyfoundtotherightofyourresults.Ifyoudonothaveyourlabreport,consultyourhealthcareproviderorthelaboratorythatperformedthetest(s)toobtainthereferencerange.Laboratorytestresultsarenotmeaningfulbythemselves.Theirmeaningcomesfromcomparisontoreferenceranges.Referencerangesarethevaluesexpectedforahealthyperson.Theyaresometimescalled"normal"values.Bycomparingyourtestresultswithreferencevalues,youandyourhealthcareproviderca

Epstein-Barr virus antigen by immunofluorescence · Epstein-Barr virus antibody titers to distinguish acute infection from past infection with EBV.MononucleosislaboratoryfindingsJumptonavigationJumptosearchMononucleosisMicrochaptersHomePatientInformationOverviewPathophysiologyEpidemiologyandDemographicsRiskFactorsCausesDifferentiatingMononucleosisfromotherDiseasesNaturalHistory,ComplicationsandPrognosisDiagnosisHistoryandSymptomsPhysicalExaminationLaboratoryFindingsOtherImagingFindingsOtherDiagnosticStudiesTreatmentMedicalTherapySurgeryPrimaryPreventionCost-EffectivenessofTherapyFutureorInvestigationalTherapiesCaseStudiesCase#1MononucleosislaboratoryfindingsOntheWebMostrecentarticlesMostcitedarticlesReviewarticlesCMEProgramsPowerpointslidesImagesAmericanRoentgenRaySocietyImagesofMononucleosislaboratoryfindingsAllImagesX-raysEcho&UltrasoundCTImagesMRIOngoingTrialsatClinicalTrials.govUSNationalGuidelinesClearinghouseNICEGuidanceFDAonMononucleosislaboratoryfindingsCDConMononucleosislaboratoryfindingsMononucleosislaboratoryfindingsinthenewsBlogsonMononucleosislaboratoryfindingsDirectionstoHospitalsTreatingMononucleosisRiskcalculatorsandriskfactorsforMononucleosislaboratoryfindingsEditor-In-Chief:C.MichaelGibson,M.S.,M.D.[1]OverviewInmostcasesofinfectiousmononucleosis,theclinicaldiagnosiscanbemadefromthecharacteristictriadoffever,pharyngitis,andlymphadenopathylastingfor1to4weeks.LaboratoryFindingsSerologictestresultsinclude:AnormaltomoderatelyelevatedwhitebloodcellcountAnincreasedtotalnumberoflymphocytesGreaterthan10%atypicallymphocytesApositivereactiontoamonospottestInpatientswithsymptomscompatiblewithinfectiousmononucleosis,apositivePaul-Bunnellheterophileantibodytestresultisdiagnostic,andnofurthertestingisnecessary.Moderate-to-highlevelsofheterophileantibodiesareseenduringthefirstmonthofillnessanddecreaserapidlyafterweek4.False-positiveresultsmaybefoundinasmallnumberofpatients,andfalse-negativeresultsmaybeobtainedin10%to15%ofpatients,primarilyinchildrenyoungerthan10yea

Viral capsid antigen (VCA). Anti-VCA IgM appears early in EBV infection and usually disappears within four to six weeks. · Early antigen (EA) Anti-EA IgG appears ...SkipdirectlytositecontentSkipdirectlytopageoptionsSkipdirectlytoA-ZlinkEpstein-BarrVirusandInfectiousMononucleosisSectionNavigationCDCHomeFacebookTwitterLinkedInSyndicateLaboratoryTestingMinusRelatedPagesEpstein-Barrvirus(EBV),alsoknownashumanherpesvirus4,isagammaherpesvirusthatoccursonlyinhumans.LaboratorytestingcanhelpdistinguishwhethersomeoneissusceptibletoEBVinfectionorhasarecentorpastinfection.HealthcareproviderscantestforantibodiestothefollowingEBV-associatedantigens:ThisphotomicrographdepictsleukemiacellsthatcontainEpstein-BarrvirususinganFAstainingtechnique.Viralcapsidantigen(VCA)Anti-VCAIgMappearsearlyinEBVinfectionandusuallydisappearswithinfourtosixweeks.Anti-VCAIgGappearsintheacutephaseofEBVinfection,peaksattwotofourweeksafteronset,declinesslightlythenpersistsfortherestofaperson’slife.Earlyantigen(EA)Anti-EAIgGappearsintheacutephaseofillnessandgenerallyfallstoundetectablelevelsafterthreetosixmonths.Inmanypeople,detectionofantibodytoEAisasignofactiveinfection.However,20%ofhealthypeoplemayhaveantibodiesagainstEAforyears.EBVnuclearantigen(EBNA)AntibodytoEBNA,determinedbythestandardimmunofluorescenttest,isnotseenintheacutephaseofEBVinfectionbutslowlyappearstwotofourmonthsafteronsetofsymptomsandpersistsfortherestofaperson’slife.OtherEBNAenzymeimmunoassaysmayreportfalsepositiveresults.MonospottestTheMonospottestisnotrecommendedforgeneraluse.TheantibodiesdetectedbyMonospotcanbecausedbyconditionsotherthaninfectiousmononucleosis.Moreover,studieshaveshownthattheMonospotproducesbothfalsepositiveandfalsenegativeresults.Forexample,theheterophileantibodiesdetectedbyMonospotareoftennotpresentinchildrenwithinfectiousmononucleosis.Atbest,theMonospottestmayindicatethatapersonhasatypicalcaseofinfectiousmononucleosis,butdoesnotconfirmthepresenceofEBVinfection.InterpretationofEBVAntibodyTestsEBVantibodytestsarenot

SkiptomaincontentMononucleosis(Mono)TestSendUsYourFeedbackChooseTopicAskaLaboratoryScientistAlsoKnownAsMononucleosisSpotTestMononuclearHeterophileTestHeterophileAntibodyTestMonospotFormalNameInfectiousMononucleosisRapidTestThisarticlewaslastreviewedonJuly21,2016.ThisarticlewaslastmodifiedonMarch24,2021.AtaGlanceWhyGetTested?Todetectandhelpdiagnoseinfectiousmononucleosis(mono)WhenToGetTested?Whenaperson,especiallyanadolescent,hassymptomsofmononucleosis,includingfever,sorethroat,swollenglands,andfatigueSampleRequired?AbloodsampledrawnfromprickingofyourfingertiporfromaveininyourarmTestPreparationNeeded?NoneLookingforTestResults?Youmaybeabletofindyourtestresultsonyourlaboratory'swebsiteorpatientportal.However,youarecurrentlyatLabTestsOnline.Youmayhavebeendirectedherebyyourlab'swebsiteinordertoprovideyouwithbackgroundinformationaboutthetest(s)youhadperformed. Youwillneedtoreturntoyourlab'swebsiteorportal,orcontactyourhealthcarepractitioner inordertoobtain yourtestresults.LabTestsOnlineisanaward-winningpatienteducationwebsiteofferinginformationonlaboratorytests.Thecontentonthesite,whichhasbeenreviewedbylaboratoryscientistsandothermedicalprofessionals, providesgeneralexplanationsofwhatresultsmightmeanforeachtestlistedonthesite,suchaswhatahighorlowvaluemightsuggesttoyourhealthcarepractitioner aboutyourhealthormedicalcondition.LookingforReferenceRanges?Thereferencerangesforyourtestscanbefoundonyourlaboratoryreport.Theyaretypicallyfoundtotherightofyourresults.Ifyoudonothaveyourlabreport,consultyourhealthcareproviderorthelaboratorythatperformedthetest(s)toobtainthereferencerange.Laboratorytestresultsarenotmeaningfulbythemselves.Theirmeaningcomesfromcomparisontoreferenceranges.Referencerangesarethevaluesexpectedforahealthyperson.Theyaresometimescalled"normal"values.Bycomparingyourtestresultswithreferencevalues,youandyourhealthcareprovidercanseeifanyofyourtestresultsfalloutsidetherangeofexpectedvalues.Valuesthatareoutsideexpectedrangescanprovidecluestohelpidentifypossibleconditi