Diagnostic criteria for Kleine-Levin syndrome (KLS) are based on the ... overlapping with other pathologies, such as Prader-Willi18 or pica;19 ...   ServicesonDemandJournalSciELOAnalyticsGoogleScholarH5M5()ArticletextinPortuguesePortuguese(pdf)ArticleinxmlformatHowtocitethisarticleSciELOAnalyticsCurriculumScienTIAutomatictranslationIndicatorsCitedbySciELOAccessstatisticsRelatedlinksCitedbyGoogleSimilarsinSciELOSimilarsinGoogleShareMoreMorePermalinkRevistadePsiquiatriadoRioGrandedoSulPrint version ISSN0101-8108Rev.psiquiatr.RioGd.Sul vol.29 no.3 PortoAlegre Sept./Dec. 2007http://dx.doi.org/10.1590/S0101-81082007000300014 CASEREPORT Kleine-Levinsyndrome:clinicalcaseanddiagnosisdifficulties  DênioLimaI;JoséAntônioZagalo-CardosoIIIPhD,Medicine.Associateprofessor,UniversidadedeBrasília,Brasília,DF,BrazilIIPhD,HealthPsychology.Professor,FaculdadedePsicologiaedeCiênciasdaEducação,UniversidadedeCoimbra,Coimbra,PortugalCorrespondence  ABSTRACTTheauthorsdescribetheKline-LevinSyndrome(KLS)andpointoutthedifficultiesregardingitsdiagnosis.Aclinicalcaseofa16-year-oldboydiagnosedandfollowedbytheauthorsispresented.Althoughhavingtheclassictrilogy(hypersomnolence;hyperphagia;hypersexuality),thisisanillustrativecaseofsuchdifficultiesunderseveraldistinctclinicalforms.Causesandconsequencesraisedbydiagnosticdifficultiesarediscussed,withspecialattentiontoaspectsconcerningdifferentialdiagnosis.Keywords:Kleine-Levinsyndrome,hypersomnolence,hyperphagia,hypersexuality,clinicalcase,differentialdiagnosis.  IntroductionDiagnosticcriteriaforKleine-Levinsyndrome(KLS)arebasedonthefollowingthreesymptomsinitiallyproposed:hypersomnia(dayandnight),hyperphagiaandhypersexuality.1Fromtheclinicalperspective,KLSischaracterizedbyachronic(withvariabledurationinaround8years),paroxysmal(withcriticalperiodsof"crises,"whichpersistforabout10daysandarerecurrentthreetofourtimesayear)andquitedisablingdisorder(bothforintellectualtasksandfortheprofessionalandsociallife),althoughitis"self-limited"astoevolutiontime,i.e.,i

To the Editor: Kleine-Levin syndrome (KLS), or Sleeping Beauty syndrome, is a ... driven by GABAergic dysfunction in Prader-Willi Syndrome.SignInUsernameForgotUsername?PasswordForgotpassword?KeepmesignedinNewUserSigninviaOpenAthensChangePasswordOldPasswordNewPasswordTooShortWeakMediumStrongVeryStrongTooLongPasswordChangedSuccessfullyYourpasswordhasbeenchangedCreateyouraccountEmailReturninguserForgetyoutPassword?EnteryouremailaddressbelowandwewillsendyoutheresetinstructionsEmailIftheaddressmatchesanexistingaccountyouwillreceiveanemailwithinstructionstoresetyourpasswordCloseForgotyourUsername?EnteryouremailaddressbelowandwewillsendyouyourusernameEmailIftheaddressmatchesanexistingaccountyouwillreceiveanemailwithinstructionstoretrieveyourusername

Kleine-Levin syndrome is a rare sleep disorder that mainly affects adolescents and is ... diseases (including mosaicism, Prader-Willi syndrome,.ThissiterequiresCookiestobeenabledtofunction.PleaseensureCookiesareturnedonandthenre-visitthedesiredpage.

Kleine–Levin syndrome (KLS) is a rare disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. Many patients also ...Kleine–LevinsyndromeFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchKleine–LevinsyndromeOthernamesFamilialhibernationsyndrome[1]SpecialtyNeurology Kleine–Levinsyndrome(KLS)isararedisordercharacterizedbypersistentepisodichypersomniaandcognitiveormoodchanges.Manypatientsalsoexperiencehyperphagia,hypersexualityandothersymptoms.Patientsgenerallyexperiencerecurrentepisodesoftheconditionformorethanadecadeandmayreturnatalaterage.Individualepisodesgenerallylastmorethanaweek,sometimeslastingformonths.Theconditiongreatlyaffectsthepersonal,professional,andsociallivesofsufferers.Theseverityofsymptomsandthecourseofthesyndromevarybetweensufferers.Patientscommonlyhaveabout20episodesoveraboutadecade.Severalmonthsgenerallyelapsebetweenepisodes.Theonsetoftheconditionusuallyfollowsaviralinfection;severaldifferentviruseshavebeenobservedtotriggerKLS.Itisgenerallyonlydiagnosedaftersimilarconditionshavebeenexcluded;MRI,CTscans,lumbarpuncture,andtoxicologytestsareusedtoruleoutotherpossibilities.Thesyndrome'smechanismisnotknown,butthethalamusisthoughttopossiblyplayarole.SPECThasshownthalamichypoperfusionofpatientsduringepisodes.KLSisveryrare,occurringatarateof1in1million,whichlimitsresearchintogeneticfactors.Theconditionprimarilyaffectsadolescentmales,thoughfemalescanalsobeaffectedandtheageofonsetvaries.Thereisnoknowncure,andthereislittleevidencesupportingdrugtreatment.Lithiumhasbeenreportedtohavelimitedeffectsincasereports,decreasingthelengthofepisodesanddurationbetweentheminsomepatients.[2]Stimulantshavebeenshowntopromotewakefulnessduringepisodes,buttheydonotcounteractcognitivesymptomsordecreasethedurationofepisodes.TheconditionisnamedafterWilliKleineandMaxLevin,[3]whodescribedcasesofthediseaseintheearly20thcentury.ItwasaddedtotheInternationalClassificationofSleepDisordersin1990.Contents1Symptoms2Cause3Diagnosis4Prevention5Treatm

ScrollToTopAboutNewsEventsContactPODCASTStoredonateMenuforPatientsandFamiliesInformation&ResourcesRareDiseaseInformationRareDiseaseVideoLibraryPatientandCaregiverResourceCenterInformationonClinicalTrialsandResearchStudiesCOVID-19ResourcesHelptoAccessMedicationsPatientAssistanceProgramsOtherFinancialAssistanceConnectwithOthersFindaPatientOrganizationRareDiseaseDay®PatientStoriesTakeActionAttendEventsAdvocateSupportCloseforPatientOrganizationsJoinMembershipNetworkValueofMembershipMembershipCriteriaApplyforMembershipNonprofitResourcesMemberResourcesRareLaunch®WebinarSeriesCOVID-19RapidResponseLeadershipSeriesOtherWaystoPartnerGrowyourorganizationPatientRegistriesAdvocacyRareDiseaseDay®RDCA-DAPMembershipProfilesAboutourMembersMemberListRareCancerCoalitionCloseforCliniciansandResearchersResourcesResourcesforMedicalProfessionalsRareDiseaseInformationResourcesforyourPatientsContinuingMedicalEducationResearchOpportunitiesResearchGrantProgramRequestsforProposalsResearchGrantRecipientsConnectLendYourExpertiseRareDiseaseDay®CloseNORDRareDiseaseAdvocacyNORD’sPolicyinActionIssueOverviewsNORDontheIssuesPolicySteeringCommitteeNORDStateReportCardNationalPartnershipsTakeActionLocallyJointheRareActionNetwork®ProjectRDACContactYourRepresentativesTakeActionRareInsights®RareInsights®5MythsAboutOrphanDrugsandtheOrphanDrugActCloseGetInvolvedDonateNowGiveWaystoGiveDonatetoResearchNORD®StoreEducateEducationalInitiativesRaiseAwarenessIdentifyRareDiseaseExpertsJoinParticipateinEventsBecomeaMemberRareCancerCoalitionEmploymentOpportunitiesCorporateCouncilAbouttheCorporateCouncilCurrentMembersCouncilCodeofConductJointheCouncilCloseHome/ForPatientsandFamilies/RareDiseaseInformation/Kleine-LevinSyndromeRareDiseaseDatabase0-9•A•B•C•D•E•F•G•H•I•J•K•L•M•N•O•P•Q•R•S•T•U•V•W•X•Y•ZPrintKleine-LevinSyndromeSynonymsofKleine-LevinSyndromeFamilialHibernationSyndromeKleine-LevinHibernationSyndromePeriodicSomnolenceandMorbidHungerGeneralDiscussionKleine-Levinsyndromeisararedisordercharacterizedbytheneedforexc

Kleine-Levin Syndrome (KLS) is a rare and complex form of ... facial palsy, an instance of Prader-Willi syndrome, an unidentified disease with ...ScreenReadersSkiptoContentHOME☰MENUNEWSHealthandDisabilityNeurologicalDisordersPublicationsDisabilityLoans&GrantsKleine-LevinSyndrome:Diagnosing,Symptoms,Causes,TreatmentPublished:2014-12-17-Updated:2021-02-23Author:ThomasC.Weiss-Contact:(DisabledWorld(www.disabled-world.com))Synopsis(i):Kleine-LevinSyndrome(KLS)isarareandcomplexformofneurologicaldisordercharacterizedbyrecurringperiodsofexcessiveamountsofsleep,alteredbehavior,aswellasareducedunderstandingoftheworld.Alongwithexcessivesleep,apersonwithKLS'swholedemeanorischanged.Theyoftentimesappeartobe,'spacey,'orchildlike.ThemajorityofpeoplewithKLSreportthateverythingseemstobeoutoffocusandthattheyarehypersensitivetolightandnoise.MainDigestKleine-LevinSyndrome(KLS)affectsmainlyadolescents,althoughitmayoccurinyoungerchildrenaswellasadults.Attheonsetofanepisode,thepersonbecomesprogressivelydrowsyandsleepsformostofthedayandnight,attimeswakingonlytoeatorusethebathroom.Eachepisodelastsdays,weeks,orevenmonthsduringwhichtimeallusualdailyactivitiescease.Peopleareunabletocareforthemselvesorattendschoolorwork.Inbetweenepisodes,peoplewithKLSseemtobeinperfecthealthwithnoevidenceofbehavioralorphysicaldysfunction.EpisodesofKLSmaycontinuefortenyearsormore.KLSissometimesreferredtoas,'SleepingBeauty,'syndrome.DiagnosingKleine-LevinSyndrome(KLS)Alongwithexcessivesleep,apersonwithKLS'swholedemeanorischanged.Theyoftentimesappeartobe,'spacey,'orchildlike.Whileawake,thepersonexperiencesdisorientation,confusion,acompletelackofenergy,aswellasalackofemotions.ThemajorityofpeoplewithKLSreportthateverythingseemstobeoutoffocusandthattheyarehypersensitivetolightandnoise.Insomeinstances,foodcravingsareapartofthesymptomstheyexperience.Instancesofuninhibitedhyper-sexualityduringanepisodehavebeenreportedbypeoplewithKLS.EpisodesofKleine-Levinsyndrome(KLS)arecyclical.Whenpresent,thesymptomsofKLScanpersistford

SkiptomaincontentThankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtainthebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodeinInternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstylesandJavaScript.AdvertisementnaturegeneticsinmedicineoriginalresearcharticlearticleCausesofdeathinPrader-Willisyndrome:Prader-WilliSyndromeAssociation(USA)40-yearmortalitysurveyDownloadPDFSubjectsClinicalgeneticsEpidemiologyNeurodevelopmentaldisordersPrognosisAbstractBackground:Prader-Willisyndrome(PWS)isarare,complex,neurodevelopmentalgeneticdisorderthatisassociatedwithhyperphagiaandmorbidobesityinhumansandleadstoashortenedlifeexpectancy.ThisreportsummarizestheprimarycausesofdeathandevaluatesmortalitytrendsinalargecohortofindividualswithPWS.Methods:TheUSPrader-WilliSyndromeAssociation(PWSA(USA))syndrome-specificdatabaseofdeathreportswascollectedthroughacursorybereavementprogramforPWSA(USA)familiesusingabriefsurveycreatedin1999.CausesofdeathweredescriptivelycharacterizedandstatisticallyexaminedusingCoxproportionalhazards.Results:Atotalof486deathswerereported(263males,217females,6unknown)between1973and2015,withmeanageof29.5 ± 16years(2months–67years);70%occurredinadulthood.Respiratoryfailurewasthemostcommoncause,accountingfor31%ofalldeaths.Maleswereatincreasedriskforpresumedhyperphagia-relatedaccidents/injuriesandcardiopulmonaryfactorscomparedtofemales.PWSmaternaldisomy15geneticsubtypeshowedanincreasedriskofdeathfromcardiopulmonaryfactorscomparedtothedeletionsubtype.Conclusions:Thesefindingshighlighttheheightenedvulnerabilitytoobesityandhyperphagia-relatedmortalityinPWS.FutureresearchisneededtoaddresscriticalvulnerabilitiessuchasgenderandgeneticsubtypeinthecauseofdeathinPWS.GenetMedadvanceonlinepublication17November2016DownloadPDFIntroductionPrader-Willisyndrome(PWS)isarare,complex,neurodevelopmentalgeneticdisorderwithmultiplecognitive,behavioral,andendocrineabnormalitiesandrecognizablephysic

Kleine-Levin Syndrome KLS Bibliography (1925-2011). ... Prader-Willi syndrome is a clinical GABAergic genetic-endocrine model of catatonia; Kleine-Levin ...FacebookTwitterGoogleKLSBibliographyKleine-LevinSyndromeBibliography(1925-2012)Arrangedbyyearofpublicationfrom1925-2012.2012JClinNeurosci.2012Jan26.[Epubaheadofprint]DistributionofHLA-DQB1allelesinpatientswithKleine-LevinSyndrome.HuangCJ,LiaoHT,YehGC,HungKL.DepartmentofMedicalResearch,CathayGeneralHospital,Taipei,Taiwan;SchoolofMedicine,FuJenCatholicUniversity,NewTaipei,Taiwan;DepartmentofBiochemistry,NationalDefenseMedicalCenter,Taipei,Taiwan.Kleine-Levinsyndrome(KLS)isararedisordercharacterizedbyrecurrentepisodesofhypersomnia,cognitiveorbehaviordisturbances,compulsiveeatingbehavior,andhypersexuality.TheetiologyofKLSremainsunknowneventhoughitsclinicalsymptomssuggestanunderlyingautoimmuneprocess.Inthisstudy,weanalyzedthehumanleukocyteantigen(HLA)typingallelesinTaiwanesepatientswithKLSusingthepolymerasechainreactionsequence-specificprimingtechnique.WereportthatanimmunoresponsiveHLA-DQB1,DQB1∗0602,wasdetectedinsignificantquantitiesinpatientswithKLS(threeof12,p=0.046)andcouldelevatetheriskofKLS(oddsratio,1.143;95%confidenceinterval,0.0982-1.329).Inconclusion,anidentificationofgenomicsusceptibilitytoKLSwillbehelpfulindeterminingtheimmunospecifictargetedtherapiesforpatientswithKLS.PMID:22285112SleepMed.2012Jan17.[Epubaheadofprint]AcaseofPANDASwithKleine-Levintypeperiodichypersomnia.DasA,RadhakrishnanA.ComprehensiveCenterforSleepDisorders,SreeChitraTirunalInstituteforMedicalSciencesandTechnology,Trivandrum695011,Kerala,India.Wereportonan11-year-oldgirl,presentingwithclinicalfeaturessuggestingbothpediatricautoimmuneneuropsychiatricdisordersassociatedwithstreptococcalinfections(PANDAS)andKleine-Levinsyndrome(KLS),whowassuccessfullytreatedwithpenicillinprophylaxis.KLSisasleepdisordercharacterizedbyrecurrentepisodesofhypersomniaandatleastoneofthefollowingsymptoms:(1)cognitiveormooddisturbances,(2)megaphagiawithcompulsiveea

SkiptomaincontentThankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtainthebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodeinInternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstylesandJavaScript.AdvertisementnaturegeneticsinmedicinegenetestreviewarticlePrader-WillisyndromeDownloadPDFAbstractPrader-Willisyndromeischaracterizedbysevereinfantilehypotoniawithpoorsuckandfailuretothrive;hypogonadismcausinggenitalhypoplasiaandpubertalinsufficiency;characteristicfacialfeatures;early-childhoodonsetobesityandhyperphagia;developmentaldelay/mildintellectualdisability;shortstature;andadistinctivebehavioralphenotype.Sleepabnormalitiesandscoliosisarecommon.Growthhormoneinsufficiencyisfrequent,andreplacementtherapyprovidesimprovementingrowth,bodycomposition,andphysicalattributes.Managementisotherwiselargelysupportive.Consensusclinicaldiagnosticcriteriaexist,butdiagnosisshouldbeconfirmedthroughgenetictesting.Prader-Willisyndromeisduetoabsenceofpaternallyexpressedimprintedgenesat15q11.2-q13throughpaternaldeletionofthisregion(65–75%ofindividuals),maternaluniparentaldisomy15(20–30%),oranimprintingdefect(1–3%).Parent-specificDNAmethylationanalysiswilldetect>99%ofindividuals.However,additionalgeneticstudiesarenecessarytoidentifythemolecularclass.Therearemultipleimprintedgenesinthisregion,thelossofwhichcontributetothecompletephenotypeofPrader-Willisyndrome.However,absenceofasmallnucleolarorganizingRNAgene,SNORD116,seemstoreproducemanyoftheclinicalfeatures.Siblingrecurrenceriskistypically<1%,buthigherrisksmaypertainincertaincases.Prenataldiagnosisisavailable.GenetMed2012:14(1):10–26.DownloadPDFOverviewPrader-Willisyndrome(PWS)isamultisystemdisorderwithanestimatedprevalenceinseveralstudiedpopulationsof1/10,000–1/30,000.Itischaracterizedbyseverehypotoniawithpoorsuckandfeedingdifficultiesinearlyinfancy,followedinlaterinfancyorearlychildhoodbyexcessiveeatingandgradualdevelopmentofmorbidobesityu

After each episode, the boy had complete remission. Our findings show that the two episodes are compatible with Kleine-Levin syndrome. The ...ArticlePDFAvailableKlein–LevinsyndromeinaboywithPrader–WillisyndromeFebruary1996Sleep19(1):13-7DOI:10.1093/sleep/19.1.13SourcePubMedAuthors:SusanShur-FenGauNationalTaiwanUniversityHospitalWei-TsuenSoongNationalTaiwanUniversityHon-ManLiuNationalTaiwanUniversityJeffHouUniversityofScienceandTechnologyofChinaShowall9authorsHideDownloadfull-textPDFReadfull-textDownloadfull-textPDFReadfull-textDownloadcitationCopylinkLinkcopiedReadfull-textDownloadcitationCopylinkLinkcopiedCitations(26)References(29)AbstractA91/2-year-oldTaiwaneseboywithPrader-Willisyndromehadthefollowingcharacteristics:difficultieswithsucking,feedingandhypotoniaduringinfancy,adysmorphicface(triangularmouth,higharchedpalate,almond-shapedeyesandlargeheadcircumferencewitharelativelynarrowbifrontaldiameter),borderlineintelligence,hypogonadism,hyperphagia,skinpickingandtruncalobesity.Theboyexperiencedtwohypersomniaepisodes,atage8and9years,withbothepisodeslastingfor10days.Duringthetwoepisodes,hewasfoundtohaveanexacerbatedcaseofhyperphagia,pica,pooremotionalcontrol,stereotypedspeechandagitatedbehavioruponawakening.Aftereachepisode,theboyhadcompleteremission.OurfindingsshowthatthetwoepisodesarecompatiblewithKleine-Levinsyndrome.Therelationshipbetweenthetwosyndromes,thePrader-WillisyndromeandtheKleine-Levinsyndrome,deservesfurtherstudy.Discovertheworld'sresearch20+millionmembers135+millionpublications700k+researchprojectsJoinforfreePublicFull-text1ContentuploadedbyHon-ManLiuAuthorcontentAllcontentinthisareawasuploadedbyHon-ManLiuonAug22,2017Contentmaybesubjecttocopyright.Sleep.19(1):13-17©1996AmericanSleepDisordersAssociationandSleepResearchSocietyKleine-LevinSyndromeinaBoyWithPrader-WilliSyndrome*Shur-FenGau,*Wei-TsuenSoong,tHon-ManLiu,:j:Jia-WoeiHou,:j:Wen-YuTsai,*Yen-NanChiu,*Yu-ChiYeh,:j:Pen-JungWangand:j:Tso-RenWang*Children'sMentalHealthCenter,DepartmentofPsychiatry,t

SkiptomaincontentHomeHealthAtoZPrader-WillisyndromeBacktoPrader-WillisyndromeCauses-Prader-WillisyndromeContentsOverviewSymptomsCausesDiagnosisManagementPrader-Willisyndromeiscausedbyagenetic problemonchromosomenumber15.Genescontaintheinstructionsformakingahumanbeing.They'remadeupofDNAandpackagedintostrandscalledchromosomes.Apersonhas2copiesofalltheirgenes,whichmeanschromosomescomeinpairs.Humanshave46chromosomes(23pairs).Oneofthechromosomesthatbelongstopairnumber15isabnormalinPrader-Willisyndrome.Around70%ofcasesofPrader-Willisyndromearetheresultof missinggeneticinformationfromthecopyofchromosome15inheritedfromthefather.Thisdefectisreferredtoas"paternaldeletion".Paternaldeletionisthoughttohappenentirelybychance,so it'spracticallyunheardoftohavemorethan1childwith Prader-Willisyndromecausedbypaternaldeletion.However, if Prader-Willisyndromeiscausedbyadifferenttypeofproblemwithchromosome15,there'saverysmallchanceyoucouldhaveanotherchildwiththesyndrome.EffectonthebrainIt'sthought theproblemwithchromosome15disruptsthenormaldevelopmentandfunctioningofpartofthebraincalledthehypothalamus.Thehypothalamusplaysaroleinmanyofthebody'sfunctions,suchasproducinghormonesandhelpingregulateappetite.AmalfunctioninghypothalamusmayexplainsomeofthetypicalfeaturesofPrader-Willisyndrome,suchasdelayedgrowthandpersistenthunger.Studiesusingadvancedbrainimagingtechnologyhaveshownthataftereating,peoplewith Prader-Willisyndromehaveveryhighlevelsofelectricalactivityinapartofthebrainknownasthefrontalcortex.Thispartofthebrainisassociatedwithphysicalpleasureandfeelingsofcontentment.Itmaybepossiblethatpeoplewith Prader-Willisyndromefindtheactofeatingimmenselyrewarding,muchlikeadrug-inducedhigh,andareconstantlyseekingfoodtoachievethathigh.Anothertheoryisthatin Prader-Willisyndrome,thehypothalamuscannotjudgetheleveloffoodinthebodyaswellasitusuallydoes. This meansthat apersonwiththesyndromealwaysfeelshungrynomatterhowmuchfoodtheyeat.Pagelastreviewed:28January2021Nextreviewdue:28January2024Previous:Sympto

A 9 1/2-year-old Taiwanese boy with Prader-Willi syndrome had the following characteristics: difficulties with sucking, feeding and hypotonia during infancy, ...Clipboard,SearchHistory,andseveralotheradvancedfeaturesaretemporarilyunavailable.SkiptomainpagecontentCOVID-19isanemerging,rapidlyevolvingsituation.Publichealthinformation(CDC)Researchinformation(NIH)SARS-CoV-2data(NCBI)Preventionandtreatmentinformation(HHS) AccesskeysNCBIHomepageMyNCBIHomepageMainContentMainNavigationSearch:SearchAdvancedClipboardUserGuideSaveEmailSendtoClipboardMyBibliographyCollectionsCitationmanagerDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSavecitationtofileFormat:Summary(text)PubMedPMIDAbstract(text)CSVCreatefileCancelEmailcitationSubject:1selecteditem:8650457-PubMedTo:Format:SummarySummary(text)AbstractAbstract(text)MeSHandotherdataSendemailCancelAddtoCollectionsCreateanewcollectionAddtoanexistingcollectionNameyourcollection:Namemustbelessthan100charactersChooseacollection:UnabletoloadyourcollectionduetoanerrorPleasetryagainAddCancelAddtoMyBibliographyMyBibliographyUnabletoloadyourdelegatesduetoanerrorPleasetryagainAddCancelYoursavedsearchNameofsavedsearch:Searchterms:TestsearchtermsWouldyoulikeemailupdatesofnewsearchresults?SavedSearchAlertRadioButtonsYesNoEmail:(change)Frequency:MonthlyWeeklyDailyWhichday?ThefirstSundayThefirstMondayThefirstTuesdayThefirstWednesdayThefirstThursdayThefirstFridayThefirstSaturdayThefirstdayThefirstweekdayWhichday?SundayMondayTuesdayWednesdayThursdayFridaySaturdayReportformat:SummarySummary(text)AbstractAbstract(text)PubMedSendatmost:1item5items10items20items50items100items200itemsSendevenwhentherearen'tanynewresultsOptionaltextinemail:SaveCancelCreateafileforexternalcitationmanagementsoftwareCreatefileCancelYourRSSFeedNameofRSSFeed:Numberofitemsdisplayed:510152050100CreateRSSCancelRSSLinkCopyActionsCiteFavoritesDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSharePermalinkCopyPagenavigationTitle&authorsAbstractSimilararticlesCitedbyPublica