Canine Herpesvirus Antibody Neutralization | Canine herpesvirus

Canine herpesvirus (CHV) is in the order Herpesvirales, family Herpesviridae, subfamily Alphaherpesvirinae, genus Varicellovirus as the species Canid ...Inthissection:Inthissection:TestDataPrintThisPageCVMAnimalHealthDiagnosticCenterLaboratoriesVirologyTestDataCanineHerpesvirusAntibodyNeutralizationCanineherpesvirus(CHV)isintheorderHerpesvirales,familyHerpesviridae,subfamilyAlphaherpesvirinae,genusVaricellovirusasthespeciesCanidalphaherpesvirus1.Asatypicalalphaherpesvirus,itsharesmanyofthepropertiescommontothisgroupofviruses.Assuch,mostinfectionsaresubclinicalandthevirusestablisheslatencyinthehostforthelifeoftheanimal.Viruswillrecrudesceforunknownreasonsatunpredictableintervalsinmanyinstanceswithnoovertsigns.Itisthroughthismechanismthatthevirusspreadsandpersistsinthecaninepopulation.ThemostsignificantclinicalfindingslinkedtoCHVinfectionsarerespiratorysigns,ocularlesionsandneonatalmortalitywhichisbyfartheissueofmostconcern.Neonatalmortalitiesmostfrequentlyoccurwithinthefirsttwoweeksoflife.Theetiologyofthissyndromeistheinfectionofasero-negativepregnantdoglateingestationsothatthereisinfectiousvirusintheenvironmentandwithtoolittletimeforantibodiestobepresentinthecolostrumtoprovidepassiveprotectiontothepuppies.The"goldenrule"statesthatadogshouldloseonlyonelitterofpuppiestoCHVassubsequentlitterswillbeprotectedfromtheclinicaldiseasebytheneutralizingantibodiesinthecolostrum.Forownersthatareconcernedabouttheneonatalpuppyinfections,itisveryhelpfultoknowtheserologicalstatusoftheanimalsthatmightbebred.Antibodypositiveanimalsareofnoconcernbutantibodynegativeanimalsshouldbemanagedtoavoidexposuresduringthepregnancy.AstherearenolicensedvaccinesforCHVintheUS,allantibodypositiveanimalsshouldbeconsideredlatentlyinfectedandcapableofspreadingthevirus.ThechartbelowrepresentsthepositiveCHVneutralizingantibodyreports(306)issuedbytheAHDCfromatotalof714testrequestsorasero-prevalenceof42.9%.Asthesearenotrandomsamplesstratifiedbyageorgeographicregion,thecaninepopulationsero-prevalencemaybediff

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