Perimembranous VSD is a common congenital heart defect that is unique in its proximity to the aortic valve, AV valves, and conductive tissue. The AV node— ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListTexHeartInstJv.38(5);2011PMC3231530TexHeartInstJ.2011;38(5):528–532.PMCID:PMC3231530PMID:22163127PerimembranousVentricularSeptalDefectwithAneurysmTwoOptionsforTranscatheterClosureChangBian,PhD,JiMa,MD,Jian'anWang,MD,PhD,GengXu,MD,PhD,JunJiang,PhD,ShuyuanYao,MD,andYuehuaiLiu,MDAuthorinformationCopyrightandLicenseinformationDisclaimerDepartmentofCardiology,SecondAffiliatedHospital,ZhejiangUniversitySchoolofMedicine,Hangzhou310009,People'sRepublicofChinaCopyright©2011bytheTexasHeart®Institute,HoustonThisarticlehasbeencitedbyotherarticlesinPMC.Wepresentourexperiencewith2optionsfordeviceclosureofperimembranousventricularseptaldefectwithaneurysm.Thirty-fourpatientswithperimembranousventricularseptaldefectwithaneurysm,agedfrom14to42years,underwenttranscatheterclosurewithmodifieddouble-diskoccluders.Asheathwasusedtodelivertheoccluderafterestablishmentofastable“arteriovenousloop”underfluoroscopy.Electrocardiographyandtransthoracicechocardiographywereusedforfollow-up.Allbut1patientexperiencedsuccessfultranscatheterclosureofperimembranousventricularseptaldefectwithaneurysm,whenoccluderswereusedin2differentpositions.Therewere19patientswhoseperimembranousventricularseptaldefectswereclosedattheinletoftheaneurysmand15patientswhosedefectswereclosedattheoutlet.Eightpatientshadaresidualshuntimmediatelyaftertheprocedure,whichdisappearedduringfollow-up.Onepatientdevelopedminoraorticregurgitation.Fourpatientswhomanifesteddifferenttypesofconductiveblockwereallinthegroupthatunderwentclosureattheinletoftheaneurysm.Noothercomplicationswereobservedduringfollow-up.Weinferthatperimembranousventricularseptaldefectwithaneurysmcanbesuccessfullyclosedwithmodifieddouble-diskoccluders.Eachofthe2optionsthatwehavepresentedfortranscatheterclos