Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by defective DNA mismatch repair, which results in genetic instability of tumors; however, ...SkiptomaincontentAdvancesinBriefFrequentMutationofβ-CateninandAPCGenesinPrimaryColorectalTumorsfromPatientswithHereditaryNonpolyposisColorectalCancerMichikoMiyaki,TakeruIijima,JunkoKimura,MasamichiYasuno,TakeoMori,YukikoHayashi,MorioKoike,NobuyukiShitara,TakeoIwamaandToshioKurokiMichikoMiyakiFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteTakeruIijimaFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteJunkoKimuraFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteMasamichiYasunoFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteTakeoMoriFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteYukikoHayashiFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteMorioKoikeFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteNobuyukiShitaraFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteTakeoIwamaFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteToshioKurokiFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteDOI: PublishedSeptember1999ArticleFigures&DataInfo&MetricsPDFAbstractHereditarynonpolyposiscolorectalcancer(HNPCC)ischaracterizedbydefectiveDNAmismatchrepair,whichresultsingeneticinstabilityoftumors;however,onlyafewtargetgeneshavebeenrecognized.OurpreviousstudydetectedalowfrequencyofAPCgenemutation(21%)incolorectaltumorsfromHNPCCpatients,incontrasttoahighfrequencyofAPCgenealteration(>70%)innon-HNPCCtumors.Becausebothβ-cateninandACPgenemutationshaverecentlybeenshowntoactivatethesamesignalingpathway,weanalyzedβ-cateninmutationinHNPCCtumors.Anotablefrequencyofβ-cateningenemutation(43%,12of28)wasfoundtooccurinHNPCCcolorectaltumors.β-Ca