Forty percent of infiltrative basal cell carcinoma expressed CK7; while ... Archival materials were retrieved from the pathology files of UMass ...SkiptomaincontentThankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtainthebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodeinInternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstylesandJavaScript.AdvertisementnaturemodernpathologyoriginalarticlearticleMicrocysticadnexalcarcinoma:animmunohistochemicalreappraisalDownloadPDFAbstractEventhoughimmunohistochemicalcomparisonsofmicrocysticadnexalcarcinomavsinfiltrativebasalcellcarcinomaanddesmoplastictrichoepitheliomaexist,theyaremostlyrestrictedtotheuseofasinglestain.Inaddition,acomparisonwithsquamouscellcarcinomahasnotbeenreportedpreviously.Inthisstudy,wecomparetheexpressionofcytokeratin(CK)15,CK7,CK20,CK903,carcinoembryonicantigen(CEA),CD10,CD15andBerEP4in13microcysticadnexalcarcinoma,eightdesmoplastictrichoepithelioma,10infiltrativebasalcellcarcinoma,andeightsquamouscellcarcinomaofwhichfiveexhibitedductaldifferentiation.Wefoundthatthemajorityofmicrocysticadnexalcarcinoma(92%)anddesmoplastictrichoepithelioma(100%)casesexpressedCK15whiletheinfiltrativebasalcellcarcinomaandsquamouscellcarcinomacaseswereallnegative.FortypercentofinfiltrativebasalcellcarcinomaexpressedCK7;whileonlytwomicrocysticadnexalcarcinomacases(15%)andonesquamouscellcarcinomawithductaldifferentiation(12%)expressedCK7intheremainingthreetumorcategories.NoneofthedesmoplastictrichoepitheliomaexpressedCK7.AlltumorswerestronglypositiveforCK903.Whiletheneoplasticcellswerenegative,luminalstainingofductalstructureswasnotedforCK7,CD15andCEAinsomeofthemicrocysticadnexalcarcinoma,desmoplastictrichoepitheliomaandsquamouscellcarcinomawithductaldifferentiationcases.Sixtypercentofinfiltrativebasalcellcarcinoma,31%ofmicrocysticadnexalcarcinoma,and25%ofsquamouscellcarcinomaexpressCD10.BerEP4expressionwasnotedin38%ofmicrocysticad