Siesindhier:StartseiteFakultätenMathematisch-NaturwissenschaftlicheFakultätFachbereicheInterfakultäreEinrichtungenTechnologienNatResourceProjectsLugduninNatResourceStrainCollectionStrainCultivationandFermentationCompoundPurificationStructureElucidationBiologicalCharacterisationProjectsADEPantibioticsLugduninGlycopeptidesInvolvedResearchGroupsAnantibioticfromthehumannoseshapesthemicrobiomeDepartmentsofInfectionBiologyandMicrobialBioactiveCompounds(IMIT)andDepartmentofOrganicChemistryMulti-resistantpathogenslikeStaphylococcusaureusspreadinalarmingratesworldwide.Newsourcesfordrugdiscoveryarerequiredandourownmicrobiomemightbesuchasource.ThehumannoserepresentsthenaturalhabitatofS.aureusandnasalcarriagepredisposesindividualstoinfectionswiththispathogen.NasaldecolonizationofS.aureuswithmupirocinisacommonstrategyforinfectionprevention.However,resistanceratesagainstmupirocinaresteadilyincreasingdemandingalternativedecolonizationstrategies.Thenasalcavityrepresentsanutrientscarceenvironmentsuggestingfiercecompetitionbetweenbacterialspeciesandpotentialproductionofinhibitorycompounds.Whilescreeningnasalbacterialisolatesforantimicrobialactivities,wediscoveredStaphylococcuslugdunensis,toproducelugdunin,anovelantibioticwithpotentactivityagainstabroadspectrumofbacteriaincludingmulti-resistantstrains.Spontaneousresistancemutationsagainstlugdunindidnotoccurunderlong-termselectivepressureandaskininfectioninmicewassuccessfullytreated.Nasalinstillationoflugdunin-producingS.lugdunensisinrodentssignificantlyreducedS.aureusandaclinicalstudywithhigh-riskpatientsdemonstratedthatcarriersofS.lugdunensishaveasix-foldreducedriskofsimultaneousS.aureuscolonization.Selectedpublicationsonnasalnutrientlimitations,nasalantimicrobialactivitiesandlugdunin:Zipperer,A.,Konnerth,M.C.,Laux,C.,Berscheid,A.,Janek,D.,Weidenmaier,C.,Burian,M.,Schilling,N.A.,Slavetinsky,C.,Marschal,M.,Willmann,M.,Kalbacher,H.,Schittek,B.,Brötz-Oesterhelt,H.,Grond,S.,Peschel,A.,Krismer,B.2016.Humancommensalsproducinganovelantibiot