LugduninFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchLugduninNamesIUPACname(1R,4R,7S,10R,13S,16R,19S)-7-(1H-Indol-3-ylmethyl)-10-isobutyl-4,13,16,19-tetraisopropyl-21-thia-3,6,9,12,15,18,23-heptaazabicyclo[18.2.1]tricosane-2,5,8,11,14,17-hexoneIdentifiersCASNumber1989698-37-43Dmodel(JSmol)InteractiveimageChEBICHEBI:133127 YChemSpider57427231PubChemCID121596231InChIInChI=1S/C40H62N8O6S/c1-19(2)15-27-35(50)45-31(21(5)6)38(53)47-32(22(7)8)39(54)48-33(23(9)10)40-44-29(18-55-40)36(51)46-30(20(3)4)37(52)43-28(34(49)42-27)16-24-17-41-26-14-12-11-13-25(24)26/h11-14,17,19-23,27-33,40-41,44H,15-16,18H2,1-10H3,(H,42,49)(H,43,52)(H,45,50)(H,46,51)(H,47,53)(H,48,54)/t27-,28+,29+,30-,31+,32-,33+,40?/m1/s1Key: QZNGYMKAHFFKCJ-ZBQZSICZSA-NInChI=1/C40H62N8O6S/c1-19(2)15-27-35(50)45-31(21(5)6)38(53)47-32(22(7)8)39(54)48-33(23(9)10)40-44-29(18-55-40)36(51)46-30(20(3)4)37(52)43-28(34(49)42-27)16-24-17-41-26-14-12-11-13-25(24)26/h11-14,17,19-23,27-33,40-41,44H,15-16,18H2,1-10H3,(H,42,49)(H,43,52)(H,45,50)(H,46,51)(H,47,53)(H,48,54)/t27-,28+,29+,30-,31+,32-,33+,40?/m1/s1Key: QZNGYMKAHFFKCJ-ZBQZSICZBYSMILESCC(C)C[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C2N[C@@H](CS2)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)Cc3c[nH]c4c3cccc4)C(C)C)C(C)C)C(C)C)C(C)CPropertiesChemicalformulaC40H62N8O6SMolarmass783.05 g·mol−1Exceptwhereotherwisenoted,dataaregivenformaterialsintheirstandardstate(at25 °C[77 °F],100 kPa).Infobox referencesChemicalcompoundLugduninisaninvestigationalantibiotic,classifiedasathiazolidine-containingcyclicpeptide.Itwasisolatedin2016afterStaphylococcuslugdunensiswasidentifiedasthespeciesofbacteriafromthehumannosethatsuppressedgrowthofspeciesofdisease-causingbacteriainthatpartofthehumanmicrobiome.[1][2][3]Lugduninisanon-ribosomallysynthesizedcyclicpeptidethatinhibitsgrowthofStaphylococcusaureusstrains.Thelugduningenesarelocatedona30-kbpoperon.ThegeneslugA,lugB,lugC,andlugDencodefournon-ribosomalpeptidesynthases,whichareprecededbyaputativeregulatorgenelugR.[4]Genelocustagprotei