Neuroblastoma is the most common extracranial solid tumor of infancy. It is an embryonal malignancy of the sympathetic nervous system ...ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointEdition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSLogInSignUpIt'sFree!Edition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSRegisterLogInNoResultsNoResultsForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointclosePleaseconfirmthatyouwouldliketologoutofMedscape.Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit.LogoutCancelhttps://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTg4Mjg0LW92ZXJ2aWV3processing....Drugs&Diseases>Pediatrics:GeneralMedicinePediatricNeuroblastomaUpdated:May14,2021Author:NormanJLacayo,MD;ChiefEditor:MaxJCoppes,MD,PhD,MBA more...ShareEmailPrintFeedbackCloseFacebookTwitterLinkedInGoogle+SectionsPediatricNeuroblastomaSectionsPediatricNeuroblastomaOverviewPracticeEssentialsPathophysiologyEtiologyEpidemiologyPrognosisPatientEducationShowAllPresentationHistoryPhysicalExaminationShowAllDDxWorkupLaboratoryStudiesImagingStudiesOtherTestsProceduresHistologicFindingsStagingShowAllTreatmentMedicalCareCooperativeGroupTreatmentStrategiesSurgicalCareConsultationsDietandActivityShowAllMedicationMedicationSummaryAntineoplasticAgentsColony-stimulatingFactorsChemoprotectiveAgentsAntineoplastics,MonoclonalAntibodyShowAllFollow-upFurtherOutpatientCareFurtherInpatientCareInpatient&OutpatientMedicationsTransferDeterrence/PreventionShowAllQuestions&AnswersMediaGalleryTablesReferencesOverviewPracticeEssentialsNeuroblastomaisthemostcommonextracranialsolidtumorofinfancy.Itisanembryonalmalignancyofthesympatheticnervoussystemarisingfromneuroblasts(pluripotentsympatheticcells).Inthedevelopingembryo,thesecellsinvaginate,migratealongtheneuraxis,andpopulatethesympatheticganglia,adrenalmedulla,andothersites.Thepatternsofdistributionofthesecell