In regard to somatic type delusions specifically, there have been a number of case reports where antidepressant medications have been effective.NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListBMJCaseRepv.2015;2015PMC4499715BMJCaseRep.2015;2015:bcr2014208375.Publishedonline2015Jul7.doi: 10.1136/bcr-2014-208375PMCID:PMC4499715PMID:26153282CaseReportTreatmentresistantsomaticdelusionsinbipolardisorderHannahSlattery1andMichaelNance1,2HannahSlattery1FlindersMedicalCentre,BedfordPark,SouthAustralia,AustraliaFindarticlesbyHannahSlatteryMichaelNance1FlindersMedicalCentre,BedfordPark,SouthAustralia,Australia2DepartmentofPsychiatry,FlindersUniversity,BedfordPark,SouthAustralia,AustraliaFindarticlesbyMichaelNanceAuthorinformationArticlenotesCopyrightandLicenseinformationDisclaimer1FlindersMedicalCentre,BedfordPark,SouthAustralia,Australia2DepartmentofPsychiatry,FlindersUniversity,BedfordPark,SouthAustralia,AustraliaCorrespondencetoDrMichaelNance,ua.vog.as.htlaeh@ecnan.leahcimAccepted2015Jun23.Copyright2015BMJPublishingGroupLtdThisarticlehasbeencitedbyotherarticlesinPMC.Twopatientseachdevelopedasingle,fixedsomaticdelusioncomplicatingtheirexistingbipolardisorder.Bothfailedtorespondtoarangeofantidepressantandantipsychoticmedications.Theyeachshowedapartialresponsetoclozapineandtoelectroconvulsivetherapy,withresolutionofmoodsymptomsanddiminutionoftheirongoingsomaticpreoccupation.Areviewofcasereportssuggestsapossiblerelationshipbetweensomaticdelusionsandaffectivedisorders.Twopatientseachdevelopedsymptomscreatingdiagnosticcomplexity.Theyhadestablishedepisodicmooddisordersbutwentontodevelopsingle,sustainedsomaticdelusionsmoretypicalofadelusionaldisorder.Thereisasuggestioninpreviousliteraturethatsomaticdelusionsoccurringinisolationrepresentaspecificsubtypeofdelusionaldisorder.1Theliteraturealsohighlightsapossiblerelationshipbetweensomaticdelusionsandaffectivedisorders,withdocumentedresponsestoantidepressants,antipsychoticmedicati