In several species of Enterobacteriaceae, AmpC is encoded on the chromosome. These species belong to the so-called group II Enterobacteriaceae ( ...SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFResearchOpenAccessPublished:26February2019Prevalenceofplasmid-mediatedAmpCinEnterobacteriaceaeisolatedfromhumansandfromretailmeatinZagazig,EgyptKatrijnL.Rensing ORCID:orcid.org/0000-0002-3485-77101,H.M.Abdallah2,AlexKoek1,GamalA.Elmowalid2,ChristinaM.J.E.Vandenbroucke-Grauls1,NashwanalNaiemi3,4&KarinvanDijk1 AntimicrobialResistance&InfectionControlvolume 8,Article number: 45(2019)Citethisarticle3024Accesses8Citations3AltmetricMetricsdetailsAbstractBackgroundTheobjectiveofthisstudywastodeterminetheprevalenceofplasmid-mediatedAmpC(pAmpC)amongEnterobacteriaceaeisolatedfromhumansandfromretailmeatinEgypt.MethodsEnterobacteriaceaewereisolatedfrompatientswithsuspectedbloodstreaminfection,humanfecalsamples,retailchickenmeatsamplesandretailsheepmeatsamples.AllgroupIEnterobacteriaceaewereanalyzedforpresenceofpAmpCgenesbyPCR.AntibioticsusceptibilitytestingwasperformedinallpAmpCpositiveisolates,followedbyphenotypicandgenotypicESBLandcarbapenemasetestingonindication.ResultsTheprevalenceofpAmpCamonggroupIEnterobacteriaceaeisolatedfrom225patientswithbloodstreaminfectionwas5.6%[95%CI2.2–13.4].Among100patientswithcommunity-onsetgastroenteritistheprevalenceinfecalsampleswas4.8%[95%CI2.1–10.7].Theprevalenceamong112chickencarcassesand100sheepmeatsampleswas2.4%[95%CI0.7–8.4]and1.1%[95%CI0.2–5.7],respectively.InhalfoftheAmpCpositiveisolateswedetectedanESBLgeneand2isolatesharboredacarbapenemasegene.Infiveisolatestherewasresistancetoatleastthreeimportantalternativeantibioticdrugs.ConclusionsWeconsidertheprevalenceofpAmpCinEgypt,asfoundinourstudy,moderatelylow.TofollowfuturetrendsinprevalenceofpAmpCworldwide,astandardizedscreeningalgorithmforthedetectionofpAmpCisneeded.BackgroundResistanceofEnterobacteriaceaetothirdgenerationcephalosporinshasbecomeaworldwideproblem[1].Themostcomm