Rapid Detection of Extended-Spectrum β-Lactamases (ESBL) | AmpC β-lactamase
AmpC β-lactamases, which confer resistance against a broad range of substrates, are less prevalent than ESBL but still a growing issue, ...ThisarticleispartoftheResearchTopicMALDI-TOFMSApplicationforSusceptibilityTestingofMicroorganismsViewall12ArticlesArticlesMiklosFuziSemmelweisUniversity,HungaryFilipaGrossoFacultyofPharmacy,UniversityofPorto,PortugalArmandPaauwNetherlandsOrganisationforAppliedScientificResearch,NetherlandsTheeditorandreviewers'affiliationsarethelatestprovidedontheirLoopresearchprofilesandmaynotreflecttheirsituationatthetimeofreview.AbstractIntroductionMaterialsandMethodsResultsDiscussionAuthorContributionsFundingConflictofInterestStatementAcknowledgmentsSupplementaryMaterialReferencesSuggestaResearchTopic>DownloadArticleDownloadPDFReadCubeEPUBXML(NLM)SupplementaryMaterialExportcitationEndNoteReferenceManagerSimpleTEXTfileBibTextotalviewsViewArticleImpactSuggestaResearchTopic>SHAREONOpenSupplementalDataMETHODSarticleFront.Microbiol.,24January2019|https://doi.org/10.3389/fmicb.2019.00013RapidDetectionofExtended-Spectrumβ-Lactamases(ESBL)andAmpCβ-LactamasesinEnterobacterales:DevelopmentofaScreeningPanelUsingtheMALDI-TOFMS-BasedDirect-on-TargetMicrodropletGrowthAssayCarlosL.Correa-Martínez1†,EvgenyA.Idelevich1†,KatrinSparbier2,MarkusKostrzewa2andKarstenBecker1*1InstituteofMedicalMicrobiology,UniversityHospitalMünster,Münster,Germany2BrukerDaltonikGmbH,Bremen,GermanyIntroduction:Antibioticresistantbacteriaareagrowingconcernworldwide.Extended-spectrumβ-lactamases(ESBL)representthemostcommonresistancemechanismofGram-negativebacteriaagainstβ-lactams,underliningtheneedforadequatediagnosticmethodsthatprovidereliableinformationintheshortesttimepossible.AmpC,alessprevalentbutincreasinglyrelevantclassofβ-lactamases,poseanadditionalchallengeastheirdetectioniscomplex.Here,wepresentanESBLandAmpCscreeningpanelemployingtheMALDI-TOFMS-baseddirect-on-targetmicrodropletgrowthassay(DOT-MGA).MaterialsandMethods:FourreferencestrainsrecommendedbytheEuropeanCommitteeonAnt
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AmpCampc beta-lactamase中文ampc beta-lactamase抗生素AmpC ESBLMetallo-beta-lactamaseampc定義AmpC beta-lactamase antibioticsampc醫學