Beta-lactamase | AmpC β-lactamase

AmpC-type β-lactamases (class C)Beta-lactamaseFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchClassofenzymesBeta-lactamaseStructureofStreptomycesalbusbeta-lactamaseIdentifiersSymbolβ-lactamasedomainPfamPF00144PfamclanCL0013InterProIPR001466PROSITEPS00146SCOP256601/SCOPe/SUPFAMAvailableproteinstructures:Pfam structures/ECOD PDBRCSBPDB;PDBe;PDBjPDBsumstructuresummaryPDB1axb,1blp,1bsg,1bue,1e25,1ghi,1i2s,1n9b,1ong,2cc1,2gdn,3dwzβ-lactamaseActionofβ-lactamaseanddecarboxylationoftheintermediateIdentifiersECno.3.5.2.6CASno.9073-60-3DatabasesIntEnzIntEnzviewBRENDABRENDAentryExPASyNiceZymeviewKEGGKEGGentryMetaCycmetabolicpathwayPRIAMprofilePDBstructuresRCSBPDBPDBePDBsumGeneOntologyAmiGO/QuickGOSearchPMCarticlesPubMedarticlesNCBIproteinsCorestructureofpenicillins(top)andcephalosporins(bottom).β-lactamringinred.Escherichiacolibacteriaontherightaresensitivetotwobeta-lactamantibiotics,anddonotgrowinthesemi-circularregionssurroundingantibiotics.E.colibacteriaontheleftareresistanttobeta-lactamantibiotics,andgrownexttooneantibiotic(bottom)andarelessinhibitedbyanotherantibiotic(top).Beta-lactamasesareenzymes(EC3.5.2.6)producedbybacteriathatprovidemulti-resistancetoβ-lactamantibioticssuchaspenicillins,cephalosporins,cephamycins,andcarbapenems(ertapenem),althoughcarbapenemsarerelativelyresistanttobeta-lactamase.Beta-lactamaseprovidesantibioticresistancebybreakingtheantibiotics'structure.Theseantibioticsallhaveacommonelementintheirmolecularstructure:afour-atomringknownasaβ-lactam.Throughhydrolysis,theenzymelactamasebreakstheβ-lactamringopen,deactivatingthemolecule'santibacterialproperties.Beta-lactamantibioticsaretypicallyusedtotreatabroadspectrumofGram-positiveandGram-negativebacteria.Beta-lactamasesproducedbyGram-negativeorganismsareusuallysecreted,especiallywhenantibioticsarepresentintheenvironment.[1]Contents1Structure2Penicillinase3ResistanceinGram-negativebacteria3.1Extended-spectrumbeta-lactamase(ESBL)3.2Types3.2.1TEMbeta-lactamases(classA)3.2.2SHVbeta-

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The genes encoding AmpC β-lactamase have spread extensively and are widely detected in bacterial plasmids. The first plasmid-encoded AmpC ...
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Beta Lactamase AmpC | AmpC β-lactamase
AmpC β-Lactamases ... A number of genera within the Enterobacteriaceae have a chromosomally encoded β-lactamase capable of producing resistance to all penicillins ...
Rapid Detection of Extended-Spectrum β-Lactamases (ESBL) | AmpC β-lactamase
AmpC β-lactamases, which confer resistance against a broad range of substrates, are less prevalent than ESBL but still a growing issue, ...
AmpC β-lactamases | AmpC β-lactamase
hydrolysing all β-lactams to some extent.1,2 Researchers have examined characteristics of both inducible and non-inducible AmpC β-lactamases such as ...
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Exposure to β-lactams can trigger a cascade of events leading to significant AmpC production and β-lactam resistance, even for infections caused by initially ...
Beta-lactamase | AmpC β-lactamase
AmpC-type β-lactamases (class C)
AmpC β-Lactamases | AmpC β-lactamase
AmpC β-lactamases are clinically important cephalosporinases encoded on the chromosomes of many of the Enterobacteriaceae and a few other ...
AmpC β-lactamase-producing Enterobacterales | AmpC β-lactamase
AmpC β-lactamase-producing Enterobacterales: what a clinician should know. Infection. 2019 Jun;47(3):363-375. doi: ...
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AmpC beta-lactamases | AmpC β-lactamase