The cat (Felis catus) is the primary but not sole reservoir for B. henselae [18], the causal agent of human cat scratch disease (CSD). Domestic cats ...SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFReviewOpenAccessPublished:04December2018BartonellainfectionsincatsanddogsincludingzoonoticaspectsAlejandraÁlvarez-Fernández1,EdwardB.Breitschwerdt2&LaiaSolano-Gallego ORCID:orcid.org/0000-0001-8479-48961 Parasites&Vectorsvolume 11,Article number: 624(2018)Citethisarticle9193Accesses24Citations12AltmetricMetricsdetailsAbstractBartonellosisisavector-bornezoonoticdiseasewithworldwidedistributionthatcaninfecthumansandalargenumberofmammalsincludingsmallcompanionanimals(catsanddogs).Inrecentyears,anincreasingnumberofstudiesfromaroundtheworldhavereportedBartonellainfections,althoughpublicationshavepredominantlyfocusedontheNorthAmericanperspective.Currently,clinico-pathologicaldatafromEuropearemorelimited,suggestingthatbartonellosismaybeaninfrequentorunderdiagnosedinfectiousdiseaseincatsanddogs.ResearchisneededtoconfirmorexcludeBartonellainfectionasacauseofaspectrumoffelineandcaninediseases.Bartonellaspp.cancauseacuteorchronicinfectionsincats,dogsandhumans.Onacomparativemedicalbasis,differentclinicalmanifestations,suchasperiodsofintermittentfever,granulomatousinflammationinvolvingtheheart,liver,lymphnodesandothertissues,endocarditis,bacillaryangiomatosis,peliosishepatis,uveitisandvasoproliferativetumorshavebeenreportedincats,dogsandhumans.ThepurposeofthisreviewistoprovideanupdateandEuropeanperspectiveonBartonellainfectionsincatsanddogs,includingclinical,diagnostic,epidemiological,pathological,treatmentandzoonoticaspects.BackgroundBartonellaisagenusofAlphaproteobacteriawithinthefamilyBartonellaceae.Bartonellaspp.aresmall,thin,shortandslightlycurved,gram-negative,hemotropicandrod-shapedbacteria[1].Theyarecatalase,oxidase,ureaseandnitratereductasenegative[1].Bartonellaspp.arefastidious,slowgrowingandfacultativeintracellularpathogensthatarehighlyadaptedtoabroadsp