In this study, we demonstrated that MCR-1 is a membrane protein that localizes to the cellular membrane. Furthermore, MCR-1 increases the loss ...ThisarticleispartoftheResearchTopicAntimicrobialResistanceAsaGlobalPublicHealthProblem:HowCanWeAddressIt?Viewall50ArticlesArticlesRaffaeleZarrilliDepartmentofPublicHealth,UniversityofNaplesFedericoII,ItalyJian-HuaLiuSouthChinaAgriculturalUniversity,ChinaXiminZengTheUniversityofTennessee,Knoxville,UnitedStatesTheeditorandreviewers'affiliationsarethelatestprovidedontheirLoopresearchprofilesandmaynotreflecttheirsituationatthetimeofreview.AbstractIntroductionMaterialsandMethodsResultsandDiscussionConclusionDataAvailabilityStatementAuthorContributionsFundingConflictofInterestSupplementaryMaterialReferencesSuggestaResearchTopic>DownloadArticleDownloadPDFReadCubeEPUBXML(NLM)SupplementaryMaterialExportcitationEndNoteReferenceManagerSimpleTEXTfileBibTextotalviewsViewArticleImpactSuggestaResearchTopic>SHAREONOpenSupplementalDataORIGINALRESEARCHarticleFront.Microbiol.,10January2020|https://doi.org/10.3389/fmicb.2019.03015ColistinResistanceGenemcr-1MediatesCellPermeabilityandResistancetoHydrophobicAntibioticsBaiyuanLi1,FangYin2,XuanyuZhao3,4,YunxueGuo3,WeiquanWang3,4,PengxiaWang3,HonghuiZhu5,YeshiYin1andXiaoxueWang3,4*1KeyLaboratoryofComprehensiveUtilizationofAdvantagePlantsResourcesinHunanSouth,CollegeofChemistryandBioengineering,HunanUniversityofScienceandEngineering,Yongzhou,China2DepartmentofBreastandThyroidSurgery,TheFifthAffiliatedHospital,SunYat-senUniversity,Zhuhai,China3KeyLaboratoryofTropicalMarineBio-resourcesandEcology,GuangdongKeyLaboratoryofMarineMateriaMedica,RNAMCenterforMarineMicrobiology,SouthChinaSeaInstituteofOceanology,ChineseAcademyofSciences,Guangzhou,China4UniversityoftheChineseAcademyofSciences,Beijing,China5StateKeyLaboratoryofAppliedMicrobiologySouthernChina,GuangdongProvincialKeyLaboratoryofMicrobialCultureCollectionandApplication,GuangdongOpenLaboratoryofAppliedMicrobiology,GuangdongMicrobialCultureCollect