Staphylococcus lugdunensis is a coagulase-negative staphylococcus (CoNS) with unusual pathogenicity resembling that of S. aureus.搜索当前位置：X-MOL学术›Eur.J.Clin.Microbiol.Infect.Dis.›论文详情Staphylococcuslugdunensis:antimicrobialsusceptibilityandoptimaltreatmentoptions.EuropeanJournalofClinicalMicrobiology&InfectiousDiseases(IF3.267)PubDate : 2019-05-29,DOI:10.1007/s10096-019-03571-6LanaTaha,MarcStegger,BoSöderquistStaphylococcuslugdunensisisacoagulase-negativestaphylococcus(CoNS)withunusualpathogenicityresemblingthatofS.aureus.UnlikeotherCoNS,S.lugdunensisremainssusceptibletomostantibiotics.Theresistancetopenicillinvarieswidely(range,15-87%worldwide),whereasmethicillinresistanceisstillrare.WeaimedtoevaluatetreatmentoptionsforinfectionscausedbyS.lugdunensisandmorespecificallytoinvestigatewhetherpenicillinGcouldbeabettertreatmentchoicethanoxacillin.SusceptibilitytestingwasperformedusingthediscdiffusionmethodforpenicillinG,cefoxitin,trimethoprim/sulfamethoxazole,erythromycin,clindamycin,gentamicin,norfloxacin,fusidicacid,rifampicin,andfosfomycin.IsolatessusceptibletopenicillinGwerefurthertestedwithagradienttestforpenicillinGandoxacillin.Ofthe540clinicalisolatestested,74.6%weresusceptibletopenicillinG.Amongthesepenicillin-susceptibleisolates,theMIC50andMIC90valuesforpenicillinGwerethreefoldlowerthanthatforoxacillin.Amajorityoftheisolatesweresusceptibletoallotherantibioticstested.Breakpointsforfosfomycinhavenotyetbeendefined,andsonoconclusionscouldbedrawn.TwoisolateswereresistanttocefoxitinandcarriedthemecAgene;whole-genomesequencingrevealedthatbothharboredtheSCCmecelementtypeIVa(2B).S.lugdunensisisolatedinSwedenweresusceptibletomosttestedantibiotics.PenicillinGmaybeamoreoptimaltreatmentchoicethanoxacillin.AlthoughcarriageofthemecAgeneisrareamongS.lugdunensis,itdoesoccur.中文翻译：Lugdunensis葡萄球菌：抗菌药敏感性和最佳治疗选择。

卢贡葡萄球菌是一种凝固酶阴性葡萄球菌（CoNS），具有与金黄色葡萄球菌相似的异常致病性。

与其他CoNS不同，卢格敦链球菌仍然对大多数抗生素敏感。

对青霉素的耐药性差异很大（范围在全球范围为15-87％），而对甲氧西林的耐药性仍然很少。

我们旨在评估针对沙门氏菌引起的感染的治疗方案，更具体地说