Multidrug-resistant Klebsiella pneumoniae and Escherichia coli isolates harboring New Delhi metallo-β-lactamase (NDM-1) were isolated from a patient who had ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListEmergInfectDisv.17(1);2011JanPMC3204653EmergInfectDis.2011Jan;17(1):103–106.doi: 10.3201/eid1701.101358PMCID:PMC3204653PMID:21192866NewDelhiMetallo-β-LactamaseinKlebsiellapneumoniaeandEscherichiacoli,CanadaMichaelR.Mulvey,JenniferM.Grant,KatherinePlewes,DianeRoscoe,andDavidA.BoydAuthorinformationCopyrightandLicenseinformationDisclaimerAuthoraffiliations:PublicHealthAgencyofCanada,Winnipeg,Manitoba,Canada(M.R.Mulvey,D.A.Boyd);VancouverGeneralHospital,Vancouver,BritishColumbia,Canada(J.M.Grant,K.Plewes,D.Roscoe)Correspondingauthor.Addressforcorrespondence:MichaelR.Mulvey,PublicHealthAgencyofCanada,1015ArlingtonSt,Winnipeg,ManitobaR3E3R2,Canada;email:ac.cg.cpsa-cahp@yevlum.leahcimCopyrightnoticeThisarticlehasbeencitedbyotherarticlesinPMC.Multidrug-resistantKlebsiellapneumoniaeandEscherichiacoliisolatesharboringNewDelhimetallo-β-lactamase(NDM-1)wereisolatedfromapatientwhohadreturnedtoCanadafromIndia.TheNDM-1genewasfoundoncloselyrelatedincompatibilitygroupA/Ctypeplasmids.TheoccurrenceofNDM-1inNorthAmericaisamajorpublichealthconcern.Keywords:Multidrugresistance,NewDelhimetallo-β-lactamase,Klebsiellapneumoniae,Escherichiacoli,carbapenemase,bacteria,expedited,Canada,dispatchCarbapenem-hydrolyzingβ-lactamases,i.e.,carbapenemases,inbacterialclinicalisolatesareanincreasingconcernbecausetheyoftenalsoconferresistancetomostotherβ-lactamantimicrobialagents.AmongEnterobacteriaceae,carbapenemasesaremainlyfoundintheAmblerclassApenicillinaseorclassBmetallo-enzymegroups.VIMandIMParethemostfrequentlyacquiredclassBenzymesandarecommonlyfoundinsouthernEuropeandtheFarEast,rarelyinNorthAmerica.Klebsiellapneumoniaecarbapenemase(KPC)classAhasbeenfoundworldwide,althoughitemergedintheeaster