Information about mupirocin, mupirocin calcium (Bactroban, Bactroban Nasal, Centany) a topical and nasal medication used for the treatment of impetigo, ...BacterialInfections101PicturesSlideshowTaketheTummyTroubleQuizHepatitisCSlideshowPicturesWhatismupirocin?Howdoesitwork(mechanismofaction)?Whataretheusesformupirocin?Whatarethesideeffectsofmupirocin?Whatisthedosageformupirocin?Whichdrugsorsupplementsinteractwithmupirocin?IsmupirocinsafetotakeifI'mpregnantorbreastfeeding?WhatelseshouldIknowaboutmupirocin?Whatismupirocin?Howdoesitwork(mechanismofaction)?Mupirocinisanantibioticthatisusedtopically(ontheskin)forthetreatmentofimpetigo,abacterialdiseaseoftheskincausedbyStaphylococcusaureus,beta-hemolyticstreptococcusandStreptococcuspyogenes.Italsoisusedintranasally(insidethenose)bypatientsandsomepeoplewhoworkinhealthcarecenterstoeliminatemethicillin-resistantStaphylococcusaureus(MRSA)thathavecolonizedtheinsideofthenose.UnlikemostotherantibioticsthatactoneitherbacterialDNAorthewallsofbacteria,mupirocinblockstheactivityofanenzymecalledisoleucyl-tRNAsynthetasewithinthebacteria.Thisenzymeisnecessaryinorderforthebacteriatomakeproteins.Withouttheabilitytomakeproteins,thebacteriadie.Becauseofitsuniquemechanismofaction,thereislittlechancethatbacteriawillhavebecomeresistanttomupirocinbecauseofexposuretootherantibiotics.MupirocintopicalcreamwasapprovedbytheFDAinDecember,1987.TheintranasalformwasapprovedinOctober1995.Whataretheusesformupirocin?MupirocinisadrugusedforthetreatmentofimpetigoandinfectionsoftheskincausedbyStaphylococcusaureus,beta-hemolyticstreptococcus,orStreptococcuspyogenes.Mupirocinisnotrecommendedforuseontheskininseriousburnsbecausemoreoftheinactiveingredientusedfortheointment,polyethyleneglycol(Miralax),maybeabsorbedandcandamagethekidneys.Thenasalointmentisusedfortheeliminationofmulti-drugresistantnasalStaphylococcusaureusinfectioninpeoplewhoarecolonizedbyStaphylococcusaureus.Mupirocinalsomaybeusedforsecondaryinfectionsasdeterminedbyyourdoctor.Whatarethesideeffects