During acute EBV disease, the number of lymphocytes increases to 50–60% of the total leukocytes in the peripheral blood (a count of 20,000–50,000/ml), of which ...LymphoreticularandHematopoeticInfectionsReturntoSyllabus INFECTIOUSMONONUCLEOSISGeneralGoal:Toknowthecauseofthisdisease,themostcommonmodesoftransmissionandthemajormanifestationsofthisdisease.SpecificEducationalObjectives:Thestudentshouldbeableto:1.recitethecommonmeansoftransmissionandthemajordiseasemanifestations.2.identifythecell-typesinwhichthevirusinfectsandestablisheslatency.3.identifythepeoplegroupingsthataremorelikelytogetlymphoproliferativediseases.4.serologicallydetermineifapatientisinfectedwiththevirusandwhatstageoftheinfectionthepatientiscurrentlyexperiencing(acute,chronic,pastinfectionsand reactivation).Reading:P.R.Murray,K.S.Rosenthal,andM.A.Pfaller.2009.MedicalMicrobiology.6thEdition.pg.529-534.MosbyElsevier,Philadephia,PA. Lecture:Dr.NealR.Chamberlain References: B.A.Cunha.Oct.19,2009,InfectiousMononucleosis,eMedicine.comhttp://emedicine.medscape.com/article/222040-overview INFECTIOUSMONONUCLEOSISInfectiousmononucleosisisacommoninfectionthatresultsinfever,sorethroat,andcervicallymphadenopathyaccompaniedbyalymphocytosis.EtiologyThecausativeagentofinfectiousmononucleosisis"Epstein-Barrvirus"(knownasEBVorhumanherpesvirus4[HHV-4]). ManifestationsInfectiousmononucleosishasaprodromethatincludesheadache,malaise,andfatiguefor4–5days.Followingtheprodrome,thereisusuallyatriadofsymptoms—fever,pharyngitis,andlymphadenopathy(TableL-14). Mostyoungchildrenwithinfectiousmononucleosisareasymptomatic;symptomsaremorepronouncedinpreviouslyuninfectedyoungadults.TableL-14.SignsandSymptomsofInfectiousMononucleosisFever:Adults38.3–38.9°C;childrenmaynothavefeverCervicallymphadenopathySeverepharyngitiswithdiffusepharyngealinflammationandtonsillarswelling;canbeexudativeornonexudativeBilateraledemaoftheuppereyelids(palpebraledema)Earlyinillness,appearanceoffaintevanescentnonpruriticmaculopapularrashPetechiaeonhardandsof