Since the 1800s, infectious mononucleosis has been recognized as a clinical syndrome consisting of fever, pharyngitis, and adenopathy.ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointEdition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSLogInSignUpIt'sFree!Edition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSRegisterLogInNoResultsNoResultsForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointclosePleaseconfirmthatyouwouldliketologoutofMedscape.Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit.LogoutCancelhttps://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjIyMDQwLW92ZXJ2aWV3processing....Drugs&Diseases>InfectiousDiseasesEpstein-BarrVirus(EBV)InfectiousMononucleosis(Mono)Updated:Apr21,2021Author:KartikaShetty,MD,FACP;ChiefEditor:MichaelStuartBronze,MD more...ShareEmailPrintFeedbackCloseFacebookTwitterLinkedInGoogle+SectionsEpstein-BarrVirus(EBV)InfectiousMononucleosis(Mono)SectionsEpstein-BarrVirus(EBV)InfectiousMononucleosis(Mono)OverviewBackgroundPathophysiologyEpidemiologyPrognosisShowAllPresentationHistoryCausesPhysicalExaminationComplicationsOtherclinicalmanifestationsShowAllDDxWorkupApproachConsiderationsLaboratoryStudiesImagingStudiesOtherTestsProceduresHistologicFindingsShowAllTreatmentMedicalCareSurgicalCareConsultationsDietActivityShowAllMedicationFollow-upFurtherOutpatientCareFurtherInpatientCareDeterrence/PreventionComplicationsPrognosisPatientEducationShowAllQuestions&AnswersTablesReferencesOverviewBackgroundEpstein-Barrvirus(EBV),alsoknownashumanherpesvirus4,isawidelydisseminateddoublestrandedDNAherpesvirus.Itisthecausativeagentofinfectiousmononucleosis("mono"or"glandularfever").Sincethe1800s,infectiousmononucleosishasbeenrecognizedasaclinicalsyndromeconsistingoffever,pharyngitis,andadenopathy.Thetermglandularfeverwasfirstusedin1889byGermanphysiciansandwastermedDrüsenfieber.Infectiousmononucleosiswasfir