Pathogenesis of lassa fever in cynomolgus macaques ... | lassa virus pathogenesis

SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFResearchOpenAccessPublished:06May2011PathogenesisoflassafeverincynomolgusmacaquesLisaEHensley1,MarkASmith2,JoanBGeisbert3,4,ElizabethAFritz3,4,KathleenMDaddario-DiCaprio1,TomLarsen2&ThomasWGeisbert3,4 VirologyJournalvolume 8,Article number: 205(2011)Citethisarticle9789Accesses76Citations0AltmetricMetricsdetailsAbstractBackgroundLassavirus(LASV)infectioncausesanacuteandsometimesfatalhemorrhagicdiseaseinhumansandnonhumanprimates;however,littleisknownaboutthedevelopmentofLassafever.Here,weperformedapilotstudytobegintounderstandtheprogressionofLASVinfectioninnonhumanprimates.MethodsSixcynomolgusmonkeyswereexperimentallyinfectedwithLASV.Tissuesfromthreeanimalswereexaminedatanearly-tomid-stageofdiseaseandcomparedwithtissuesfromthreeanimalscollectedatterminalstagesofdisease.ResultsDendriticcellswereidentifiedasaprominenttargetofLASVinfectioninavarietyoftissuesinallanimalsatday7whileKupffercells,hepatocytes,adrenalcorticalcells,andendothelialcellsweremorefrequentlyinfectedwithLASVintissuesofterminalanimals(days13.5-17).Meningoencephalitisandneuronalnecrosiswerenoteworthyfindingsinterminalanimals.Evidenceofcoagulopathywasnoted;however,thedegreeoffibrindepositionintissueswaslessprominentthanhasbeenreportedinotherviralhemorrhagicfevers.ConclusionThesequenceofpathogeniceventsidentifiedinthisstudybeginstoshedlightonthedevelopmentofdiseaseprocessesduringLassafeverandalsomayprovidenewtargetsforrationalprophylacticandchemotherapeuticinterventions.IntroductionLassafever(LF)isaseverehemorrhagicfever(HF)thatisendemicinWestAfricancountrieswiththehighestincidenceintheRepublicofGuinea,SierraLeone,Liberia,andNigeria.ItisestimatedthatLassavirus(LASV)infectsover300,000individualsperyearacrossthisregion,causingover3,000deaths[1].ThecasefatalityrateforLFisestimatedtobeapproximately15%inhospitalizedpatientsandhasbeenreportedtobegreaterthan50%inseveraloutbreaks[1,2].Humaninfectionisassociatedwithcontactwithawidelydistributedandh

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