Placental characteristics of Monochorionic Diamniotic twin pregnancies in relation to perinatal outcome. Placenta. 2008:976–81. 18. Ghidini A, ...SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFResearcharticleOpenAccessPublished:04July2018Istherearelationshipbetweenfetalsexandplacentalpathologicalcharacteristicsintwingestations?ShayestehJahanfar ORCID:orcid.org/0000-0001-6149-10671&KennethLim2 BMCPregnancyandChildbirthvolume 18,Article number: 285(2018)Citethisarticle4166Accesses14Citations1AltmetricMetricsdetailsAbstractBackgroundPlacentaplaysacentralroleinmediatinggrowthanddevelopmentoffetuses.Sex-specificplacentasmaycomplicatethisrole.MethodsThestudyaimedatinvestigatingtheassociationbetweenfetalsexandplacentalpathologicalfindingsintwingestationsusinggeneralizedestimatingequationmodeling.Weusedalargepopulation-basedclinicaldataborninBritishColumbia(BC)andlinkedthefetal-maternaldatatohand-searchedpathologyreportsof1493twinplacentasfromtwinsborninBCWomenhospital.Weanalyzedthedatausinggeneralizedestimatingequationstakingtheclusternatureoftwinsintoconsideration.ResultsAbout26.5%oftwinsweremonochorionicand73.5%weredizygotic.Mosttwinsweremale(51.3%).About2/3oftwinsweresexconcordant(66.6%).Ofthesexconcordanttwins,similarpercentagesweremale-male(34.7%)andfemale-female(31.2%).Ofthesexdiscordanttwins,themale-female(33.3%)groupconstitutedabout1/3ofthewholepopulation.Adjustedforchorionicity,birthweightdiscordance≥30%andgestationalage,theoddsofchorionitis(1.38,95%CI = 1.04–1.84),anastomosis(1.63,95%CI = 1.22–2.19),unequalsharingofplacenta(1.72,95%CI = 1.11–2.64),placentalinflammation(1.30,95%CI = 1.05–1.62)andlesions(1.83,95%CI = 1.02–3.31)werehigherinmaletwinscomparedwithfemales.Twinsofeithersexfromsex-discordantpairswerelesslikelytohaveplacentalanastomosiscomparedtothereferencecategory.Malesfrommale-malepairshadhigheroddsofunequalplacentalsharing(74%higher)andcompositeinflammation(52%higher)comparedwiththereferencetwins.ConclusionOurfindingssuggestarelatio