ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointEdition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSLogInSignUpIt'sFree!Edition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSRegisterLogInNoResultsNoResultsForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointclosePleaseconfirmthatyouwouldliketologoutofMedscape.Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit.LogoutCancelhttps://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cDovL2VtZWRpY2luZS5tZWRzY2FwZS5jb20vYXJ0aWNsZS8yODgzNzktdHJlYXRtZW50processing....Drugs&Diseases>PsychiatryWernicke-KorsakoffSyndrome Treatment&ManagementUpdated:May16,2018Author:GlenLXiong,MD;ChiefEditor:DavidBienenfeld,MD more...ShareEmailPrintFeedbackCloseFacebookTwitterLinkedInWhatsAppSectionsWernicke-KorsakoffSyndromeSectionsWernicke-KorsakoffSyndromeOverviewBackgroundEtiologyPathophysiologyEpidemiologyPrognosisPatientEducationShowAllPresentationHistoryPhysicalExaminationShowAllDDxWorkupApproachConsiderationsLaboratoryTestsImagingStudiesShowAllTreatmentApproachConsiderationsDietandActivityReferralandFollow-UpCareDeterrenceandPreventionNeuropsychologicalTestingandRehabilitationShowAllMedicationMedicationSummaryNutrientsShowAllQuestions&AnswersReferencesTreatmentApproachConsiderationsWernicke-Korsakoffsyndrome(unlikeacuteWernickeencephalopathy)isoftenalong-termcondition.ItshouldbetreatedaggressivelyasWernickeencephalopathyintheacutesetting,butwiththeunderstandingthatitisrarefortheKorsakoffamnesticstatetofullyreversewithtreatment.Afteracourseoftreatmentwithhigh-doseparenteralthiamineandreversaloftheacuteeffectsofWernickeencephalopathy,ifthereisnoimprovementintheKorsakoffamnesticstateorothermentalstatusabnormalitiesfor7days,thenastrategyofsecondaryharmpreventionshouldbepursued.Thisincludesmaintenancewithoralthiaminetopreventfurtherinsult,aswellasconsiderationforrehabilitation,treatmentofcomorbiddeficienciesandmedicalconditions,andconsideration