The CDC recommends erythromycin for treatment of C trachomatis pneumonia in infants. However, the effectiveness is approximately 80% and a ...ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointEdition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSLogInSignUpIt'sFree!Edition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSRegisterLogInNoResultsNoResultsForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointclosePleaseconfirmthatyouwouldliketologoutofMedscape.Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit.LogoutCancelhttps://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cDovL2VtZWRpY2luZS5tZWRzY2FwZS5jb20vYXJ0aWNsZS8yOTczNTEtb3ZlcnZpZXc=processing....Drugs&Diseases>PulmonologyChlamydialPneumoniasUpdated:Feb24,2020Author:YujiOba,MD,FCCP;ChiefEditor:ZabMosenifar,MD,FACP,FCCP more...ShareEmailPrintFeedbackCloseFacebookTwitterLinkedInGoogle+SectionsChlamydialPneumoniasSectionsChlamydialPneumoniasOverviewPathophysiologyEpidemiologyPresentationAlternateDiagnosesTestsinChlamydialPneumoniasChestRadiographyHistologicFindingsAntimicrobialsinChlamydialPneumoniasManagementofCpneumoniaePneumoniaManagementofCpsittaciPneumoniaManagementofCtrachomatisPneumoniaPreventionPrognosisSpecialConsiderationsShowAllReferencesOverviewOverviewThreechlamydialorganismsarepathogenictohumans:Chlamydophilapneumoniae,Chlamydophilapsittaci,andChlamydiatrachomatis.Thesearesmall,gram-negative,obligateintracellularorganisms.Allthreespeciescancausepneumoniainhumans.Cpneumoniaecausesmildpneumoniaorbronchitisinadolescentsandyoungadults.Olderadultsmayexperiencemoreseverediseaseandrepeatedinfections.Cpsittacicausespsittacosisorornithosisafterexposuretoaninfectedbird.Ornithosisisthepreferredterm,becausealmostanybirdcantransmittheorganism.TheclinicalspectrumofCpsittaciinfectionrangesfromanasymptomaticinfectiontoafulminanttoxicsyndrome.Patientswithornithosismostcommonlypresentwithpneumoniaorfeverofunknownorigin.Ctra

Chlamydia pneumoniae is an obligate intracellular bacterium that ... for the treatment of community-acquired pneumonia due to Chlamydia ...

Doctors can use antibiotics to treat C. pneumoniae infections, although most people will recover on their own without medicine. Doctors can use several types of ...SkipdirectlytositecontentSkipdirectlytopageoptionsSkipdirectlytoA-ZlinkChlamydiapneumoniaeInfectionSectionNavigationCDCHomeFacebookTwitterLinkedInSyndicateDiagnosis,Treatment,andComplicationsMinusRelatedPagesOnThisPageDiagnosisTreatmentComplicationsDiagnosisDoctorsmaytesttoseeifapatienthasChlamydiapneumoniaeinfectionby:Laboratorytestthatinvolvestakingasampleofsputum(phlegm)orswabfromthenoseorthroatBloodtestTreatmentDoctorscanuseantibioticstotreatC.pneumoniaeinfections,althoughmostpeoplewillrecoverontheirownwithoutmedicine.DoctorscanuseseveraltypesofantibioticstotreatC.pneumoniaeinfections.IfadoctordiagnosesyouoryourchildwithaC.pneumoniaeinfection,theywilldecidethebesttreatment.ComplicationsC.pneumoniaeinfectionismostoftenamilddisease.However,seriouscomplicationscanoccurthatresultinneedingcareortreatmentinahospital,including:Encephalitis(swellinginthebrain)Myocarditis(swellingoftheheart)C.pneumoniaecancausechronicinfection.SomeexpertsthinkthatchronicC.pneumoniaeinfectionmightcontributetochronicconditions,suchasasthma,arthritis,andatherosclerosis(plaquebuildupinyourarteries). RelatedLinksForCliniciansandLaboratorians:TreatmentPagelastreviewed:January10,2019Contentsource:NationalCenterforImmunizationandRespiratoryDiseases,DivisionofBacterialDiseaseshomeChlamydiapneumoniaeInfectionHomeAbouttheDiseaseexpandCauses,HowItSpreads,&PeopleatIncreasedRiskSigns&SymptomsDiagnosis,Treatment,&ComplicationsPreventionHistory&DiseasePatternsFastFactsForClinicians&LaboratoriansexpandDiseaseSpecificsClinicalFeatures&ComplicationsTreatmentDiagnosticMethodsSpecimenSubmissionforDiagnosticTestingSurveillance&ReportingPublicationsFacebookTwitterLinkedInSASstatsExitNotification/DisclaimerPolicyCloseLinkswiththisiconindicatethatyouareleavingtheCDCwebsite.TheCentersforDiseaseControlandPrevention(CDC)cannotattesttotheaccuracyofanon-fe

TurnonmoreaccessiblemodeTurnoffmoreaccessiblemodeSkipRibbonCommandsSkiptomaincontentTurnoffAnimationsTurnonAnimationsOurSponsorsLogin|RegisterMenuLogin|RegisterHomeOurSponsorsAges&StagesAges&StagesAgesandStagesPrenatalDecisionstoMakeDeliveryandBeyondBaby(0-12mos.)Diapers＆ClothingFormulaFeedingNutritionToddler1-3yrs.NutritionPreschool3-5yrsGradeSchool5-12yrs.Teen12-18yrs.YoungAdult18-21yrs.HealthyLivingHealthyLivingHealthyLivingNutritionFitnessSportsOralHealthEmotionalWellnessGrowingHealthySleepSafety&PreventionSafety&PreventionSafetyandPreventionImmunizationsAtHomeAtPlayOnTheGoAllAroundFamilyLifeFamilyLifeFamilyLifeMedicalHomeFamilyDynamicsMediaWork&PlayGettingInvolvedinYourCommunityHealthIssuesHealthIssuesHealthIssuesConditionsInjuries&EmergenciesVaccinePreventableDiseasesNewsNewsTips&ToolsTips&ToolsTipsandToolsAskThePediatricianFindaPediatricianNewslettersSymptomCheckerWebinarsHealthyChildrenMagazineHealthyChildrenTextingProgramOurMissionOurMissionOurMissionAAPinActionMedicalEditor&ContributorsSponsorsSponsorshipOpportunitiesSpreadtheWordShopAAPFindaPediatrician HealthIssuesConditionsAbdominalADHDAllergies&AsthmaAutismCancerChest&LungsChronicConditionsCleft&CraniofacialCommonSurgicalProceduresCOVID-19DevelopmentalDisabilitiesEarNose&ThroatEmotionalProblemsEyesFeverFromInsectsorAnimalsGenitalsandUrinaryTractGlands&GrowthHeadNeck&NervousSystemHeartInfectionsLearningDisabilitiesObesityOrthopedicPreventionSeizuresSexuallyTransmittedSkinTobaccoTreatmentsInjuries&EmergenciesVaccinePreventableDiseasesInThisSectionHealthyChildren>HealthIssues>Conditions>Chest&Lungs>ChlamydiaPneumoniaeInfectionsHealthIssuesListenEspañolTextSizeChlamydiaPneumoniaeInfectionsPageContentArticleBodyWhenyouhearthewordchlamydia,youmightthinkofthesexuallytransmitteddisease(STD)bythatname.TheSTDiscausedbyChlamydiatrachomatis,onespeciesofChlamydiabacteria.Anotherspecies,calledChlamydia(orChlamydophila)pneumoniae,causesrespiratoryillnesses.Theselunginfectionsarespreadinthesamewayasmanyotherrespirator

SkipdirectlytositecontentSkipdirectlytopageoptionsSkipdirectlytoA-ZlinkChlamydiapneumoniaeInfectionSectionNavigationCDCHomeFacebookTwitterLinkedInSyndicateTreatmentMinusRelatedPagesIllnesscausedbyChlamydiapneumoniaeisusuallyself-limitingandpatientsmaynotseekcare.Clinicianscantreatthediseaseonacase-by-casebasiswith:Macrolides(azithromycin)—first-linetherapyTetracyclines(tetracyclineanddoxycycline)FluoroquionolonesNote:Cliniciansshouldnotprescribetetracyclinesforyoungchildrenundernormalcircumstances.C.pneumoniae showsinvitroresistancetothefollowingantibiotics,whicharenotrecommendedfortreatment:PenicillinAmpicillinSulfadrugsSymptomsof C.pneumoniae infectioncanreappearafterashortorconventionalcourseofantibiotics.Persistentinfectionaftertreatmenthasbeendemonstratedbyrecoveryofviablebacteria;therefore,asecondarycourseoftreatmentmayberecommended.Community-AcquiredPneumonia(CAP)TreatmentGuidelinesIDSAandATSConsensusGuidelinesontheManagementofCommunity-AcquiredPneumoniainAdults,2007pdficon[46pages]externaliconPIDSandIDSAClinicalPracticeGuidelinesontheManagementofCommunity-AcquiredPneumoniainInfantsandChildrenOlderThan3MonthsofAge,2011pdficon[52pages]externaliconReferencesBeattyW,MorrisonR,ByrneG.Persistentchlamydiae:Fromcellculturetoaparadigmforchlamydialpathogenesis.MicrobiolRev.1994;58:686–99.BlasiF,TarsiaP,AlibertiS. Chlamydophilapneumoniae. ClinMicrobiolInfect.2009;15:29–35.BurilloA,BouzaE. Chlamydophilapneumoniae. InfectDisClinNAm.2010;24:61–71.CunhaBA.Theatypicalpneumonias:Clinicaldiagnosisandimportance. ClinMicrobioInfect.2006;12:12–24.Pagelastreviewed:January10,2019Contentsource:NationalCenterforImmunizationandRespiratoryDiseases,DivisionofBacterialDiseaseshomeChlamydiapneumoniaeInfectionHomeAbouttheDiseaseexpandCauses,HowItSpreads,&PeopleatIncreasedRiskSigns&SymptomsDiagnosis,Treatment,&ComplicationsPreventionHistory&DiseasePatternsFastFactsForClinicians&LaboratoriansexpandDiseaseSpecificsClinicalFeatures&ComplicationsTreatmentDiagnosticMethodsSpecimenSubmissionforD

Home»DecisionSupportinMedicine»InfectiousDiseasesOVERVIEW:WhateveryclinicianneedstoknowPathogennameandclassificationChlamydiapneumoniae—anintracellularorganismwithacellmembranebutnocellwallInmanyseries,itisthethirdorfourthmostcommoncauseofcommunity-acquiredpneumoniae(CAP).However,giventhedifficultiesinmakinganaccurateetiologicaldiagnosisofinfectionbythismicro-organism,thereisstillsomecontroversyastowhetherornotthisisamajorpathogeninCAP.Co-infectionswithS.pneumoniaeandM.pneumoniaeoccurfrequently.ContinueReadingC.pnemoniaehasbeenimplicatedinquiteanumberofchronicillnesses,suchasatherosclerosis,asthma,arthritis,multiplesclerosis,andmanyothers.However,theevidenceforcausationinmostoftheseisnotstrong.MostoftheempiricantibiotictreatmentsusedforCAPwilltreatC.pneumoniae.Chlamydiaeareobligateintracellularbacterialpathogens.RecenttaxonomicanalysisofthegenusChlamydiahasfoundthattherearetwogenera–ChlamydiaandChlamydophila.Chlamydophilahasthefollowingspecies:C.pecorum,whichcausesinfectionincattle,sheep,andkoalas;C.pneumoniaeandC.psittaci;C.abortus,whichcausesovineandbovineabortion;C.cavieae,whichcausesguineapigconjunctivitis;andC.felis,whichcauseskeratoconjunctivitisincats.C.pneumoniaehasagram-negativecellwallandauniquedevelopmentcyclewithelementary(theinfectiousparticle)andreticulate(theintracellularreplicativeparticle)bodies.Afterinfection,elementarybodies(200-400nmindiameter)attachtothehostcellbyelectrostaticbindingandenterthecellbyendocytosis.Elementarybodies(EB)differentiateintoreticulatebodies(RB)thatundergobinaryfission.Afterabout36hours,thereticulatebodies(RBs)differentiatebackintoelementarybodies(EBs).AlargenumberofEBsaccumulateinthecell(approximately500-1000),yethostcellfunctionisnotaffected.Theselargeaccumulations,ormicrocolonies,arereferredtoasintracytoplasmicinclusions.Duringthisprocess,chlamydialantigensarereleasedontothehostcellsurface,inducingahostimmuneresponse.ReleaseofEBsoccursbyseveralprocesses,includingextrusionoftheinclusion.ItisalsolikelythatC.pneumoniaeente

pneumoniae infection in asthma patients be proven, C. pneumoniae eradication from the airways would become an important aspect of asthma treatment. Antibiotics ...HomeEditorialBoardReviewsContactUsSearchChlamydophila(Chlamydia)pneumoniaeAuthors:FrancescoBlasi,M.D.PaoloTarsia,M.D.Previousauthor:LisaA.Jackson,M.D.,J.ThomasGrayston,M.D.,1997Edition,2002EditionMonographTablesWhat'sNewReviewsHistoryMICROBIOLOGYChlamydiaisanobligateintracellularbacteriathathasauniquebiphasicdevelopmentalcycle.Thegenuscontainsthreespecieswhicharehumanpathogens;C.psittaci,C.trachomatis,andC.pneumoniae(TWAR).Chlamydiaehavecellwallswithinnerandoutermembranes,replicatebybinaryfission,containDNA,RNA,andribosomes,andsynthesizesomeproteins.TheycannothoweversynthesizeATPorGTPandmustrelyonthehostcellforATP.Thebacteriumpresentsintwodevelopmentalforms:infectiveelementarybodiesandreproductivereticulatebodies.Thesmall,denseelementarybodyisthemetabolically-inactiveinfectiousformoftheorganism.Elementarybodieshavearigidcellwallresultingfromdisulfidecross-linkingofenvelopeproteins,allowingsurvivaloutsideofthehostcell.Afterinfectionofthehostcellbyreceptor-mediatedendocytosis,theelementarybodiesdifferentiateintoreticulatebodies.Thereticulatebodyisthelarger,metabolicallyactiveformoftheorganism.Insidethehostcell,thereticulatebodydividesbybinaryfission,formingamicrocolonyreferredtoasachlamydialinclusion.Afteraperiodofgrowthanddivision,thereticulatebodiesreorganizeandcondensetoformnewelementarybodies.Afterhostcelllysis,theelementarybodiesarereleasedtoinitiatenewinfectiouscycles.ThefirstC.pneumoniaeisolateswereserendipitouslyobtainedfromconjunctivalculturesofchildrenduringtrachomavaccinestudiesinthe1960s.Theorganismisnot,however,associatedwitheyeinfectionanditsroleasahumanpathogenwasnotfullydefineduntil1983,whenthefirstrespiratoryisolatewasobtained(26).SincethattimeC.pneumoniaehasbeenidentifiedasanimportantcauseofcommunity-acquiredrespiratoryinfections,suchascommunity-acquiredpneumoniaandacutebronchitis.ThefirstC

Old and new macrolides are effective against C. pneumoniae and have been recommended as first-line treatment. New fluoroquinolones are also ...SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFCasereportOpenAccessPublished:17January2012SuccessfultreatmentofChlamydophilapneumoniaeacuterespiratorydistresssyndromewithextracorporealmembraneoxygenator:acasereportanddiagnosticreviewDavidDeBels1,PhilippeGottignies1,MarijkeReynders2,SébastienRoques1,StephanWilmin1,Véronique-YvetteMiendjeDeyi3,SophieJamart1&JacquesDevriendt1 JournalofMedicalCaseReportsvolume 6,Article number: 20(2012)Citethisarticle18kAccessesMetricsdetailsAbstractIntroductionChlamydophilapneumoniaeisarespiratorypathogenknowntoinfecttheupperandlowerrespiratorytracts.Infectionseveritycanrangefromsub-clinicalpulmonaryinfectiontoacuterespiratorydistresssyndrome.CasepresentationApreviouslyhealthy62-year-oldCaucasianmanwasadmittedtoourhospitalforacuterespiratoryfailure.Serumsamplesobtainedeveryweekstartingfromthedayofadmissionshowedclear-cutseroconversionforC.pneumoniaeantibodies.Allotherculturesobtainedduringthefirstdaysofhospitalizationwerenegative.Despitemaximalventilatorysupport(highpositiveendexpiratorypressure,fractionofinspiredoxygenof1.0,nitricoxideinhalation,neuromuscularblockingagentsandpronepositioning),ourpatientremainedseverelyhypoxemic,whichledustoinitiateanextracorporealmembraneoxygenationtreatment.Extracorporealmembraneoxygenationandhemodiafiltrationwerewithdrawnonday12.Ourpatientwasextubatedonday18anddischargedfromourIntensiveCareUnitonday20.Hewenthomeamonthlater.ConclusionWedescribethefirstpublishedcaseofacuterespiratorydistresssyndromeduetoC.pneumoniaeinfectionsuccessfullytreatedbyextracorporealmembraneoxygenation,averyusefultoolinthissyndrome.AquickandspecificmethodforthedefinitediagnosisofChlamydophilainfectionshouldbedeveloped.PeerReviewreportsIntroductionChlamydophilapneumoniaeisanobligateintracellularGram-negativebacterium.Thespectrumofdisease,inadditiontopneumoniaandinflu

Persistent infections with Chlamydia pneumoniae have been implicated in the development of chronic diseases, such as atherosclerosis and asthma.NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListAntimicrobAgentsChemotherv.46(2);2002FebPMC127037AntimicrobAgentsChemother.2002Feb;46(2):409–412.doi: 10.1128/AAC.46.2.409-412.2002PMCID:PMC127037PMID:11796350EffectofProlongedTreatmentwithAzithromycin,Clarithromycin,orLevofloxacinonChlamydiapneumoniaeinaContinuous-InfectionModelAndreiKutlin,PatriciaM.Roblin,andMargaretR.Hammerschlag*AndreiKutlinDepartmentofPediatrics,StateUniversityofNewYorkHealthScienceCenteratBrooklyn,Brooklyn,NewYorkFindarticlesbyAndreiKutlinPatriciaM.RoblinDepartmentofPediatrics,StateUniversityofNewYorkHealthScienceCenteratBrooklyn,Brooklyn,NewYorkFindarticlesbyPatriciaM.RoblinMargaretR.HammerschlagDepartmentofPediatrics,StateUniversityofNewYorkHealthScienceCenteratBrooklyn,Brooklyn,NewYorkFindarticlesbyMargaretR.HammerschlagAuthorinformationArticlenotesCopyrightandLicenseinformationDisclaimerDepartmentofPediatrics,StateUniversityofNewYorkHealthScienceCenteratBrooklyn,Brooklyn,NewYork*Correspondingauthor.Mailingaddress:DepartmentofPediatrics,Box49,SUNYDownstateMedicalCenteratBrooklyn,450ClarksonAve.,Brooklyn,NY11203-2098.Phone:(718)245-4075.Fax:(718)245-2118.E-mail:[email protected];Revised2001Aug14;Accepted2001Nov4.Copyright©2002,AmericanSocietyforMicrobiologyThisarticlehasbeencitedbyotherarticlesinPMC.PersistentinfectionswithChlamydiapneumoniaehavebeenimplicatedinthedevelopmentofchronicdiseases,suchasatherosclerosisandasthma.Althoughazithromycin,clarithromycin,andlevofloxacinarefrequentlyusedforthetreatmentofrespiratoryC.pneumoniaeinfections,littleisknownaboutthedoseanddurationoftherapyneededtotreataputativechronicC.pneumoniaeinfection.Inthisstudy,weinvestigatedtheeffectofprolongedtreatmentwithazithromycin,clarithromycin,orlevoflox

SkipdirectlytositecontentSkipdirectlytopageoptionsSkipdirectlytoA-ZlinkChlamydiapneumoniaeInfectionSectionNavigationCDCHomeFacebookTwitterLinkedInSyndicateCauses,HowItSpreads,andPeopleatIncreasedRiskMinusRelatedPagesChlamydiapneumoniaeisatypeofbacteriathatcausesrespiratorytractinfections,suchaspneumonia(lunginfection).Thebacteriacauseillnessbydamagingtheliningoftherespiratorytractincludingthethroat,windpipe,andlungs.Somepeoplemaybecomeinfectedandhavemildornosymptoms.HowItSpreadsPeoplespreadC.pneumoniaebycoughingorsneezing,whichcreatessmallrespiratorydropletsthatcontainthebacteria.Otherpeoplethenbreatheinthebacteria.Peoplecanalsogetsickiftheytouchsomethingwithdropletsfromasickpersononitandthentouchtheirmouthornose.MostpeoplewhospendashortamountoftimewithsomeonewhohasC.pneumoniaeinfectionusuallydonotbecomeill.However,itiscommonforthebacteriatospreadbetweenpeoplewholivetogether.C.pneumoniaeinfectionsusuallyhavelongincubationperiods(thetimebetweenbreathinginthebacteriaanddevelopingsymptoms).Symptomsusuallybegin3to4weeksafterexposure.1,2,3,4,5,6,7PeopleatIncreasedRiskPeopleofallagescangetsickfromC.pneumoniae.Itmostcommonlyinfectspeopleforthefirsttimewhentheyareschool-agedchildrenoryoungadults.However,reinfectionismostcommoninolderadults.Peopleatincreasedriskincludethosewholiveorworkincrowdedsettingswhereoutbreaksmostcommonlyoccur8,suchas:SchoolsCollegeresidencehallsMilitarybarracksNursinghomesHospitalsPrisonsOlderadultsareatincreasedriskforseverediseasecausedbyC.pneumoniaeinfection,includingpneumonia.Footnotes1CsangoPA,HaraldstadS,PedersenJE,JagarsG,ForelandI.RespiratorytractinfectionduetoChlamydiapneumoniaeinmilitarypersonnel.ScandJInfectDisSuppl.1997;104:26–9.2DawoodFS,AmbroseJF,RussellBPetal.OutbreakofpneumoniainthesettingoffatalpneumococcalmeningitisamongUSArmytrainees: potentialroleofChlamydiapneumoniaeinfection.BMCInfectDis.2011;11:157.3OktemIM,EllidokuzH,SevincC,etal.PCRandserologywereeffectiveforidentifyingChlamydophilapneumoniaeinalowerrespiratoryinfectionoutbre

What Is the Treatment for Chlamydia Pneumoniae? ... Chlamydia pneumoniae infections may be cured with antibiotics, however people often recover on ...homeinfectionscenterTopicGuideCanChlamydiaPneumoniaeBeCured?MedicalAuthor:JohnP.Cunha,DO,FACOEPReviewedon8/26/2020DefinitionWhatIsChlamydiaPneumoniae?SymptomsWhatAreSymptomsofChlamydiaPneumoniae?CausesWhatCausesChlamydiaPneumoniae?DiagnosisHowIsChlamydiaPneumoniaeDiagnosed?TreatmentWhatIstheTreatmentforChlamydiaPneumoniae?ComplicationsWhatAreComplicationsofChlamydiaPneumoniae?PreventionHowDoYouPreventChlamydiaPneumoniae?GuideCanChlamydiaPneumoniaeBeCured?TopicGuideWhatIsChlamydiaPneumoniae?Chlamydiapneumoniaeisbacteriathatcandamagetheliningoftherespiratorytractincludingthethroat,lungs,andwindpipe,causingrespiratorytractinfectionssuchaspneumoniaorbronchitis. C.pneumoniaeisacommoncauseofcommunity-acquiredpneumoniaorlunginfectionsdevelopedoutsideofahospital. ChlamydiapneumoniaeisnotthesamebacteriumasChlamydiatrachomatis,whichisresponsibleforthesexuallytransmittedinfection(STI)chlamydia.WhatAreSymptomsofChlamydiaPneumoniae?Chlamydiapneumoniaegenerallycausesmildillnessandinsomecasesnosymptomsatall.Itusuallytakesabout3to4weeksforsymptomstoappearafterexposuretothebacteria. CommonsymptomsofupperrespiratorytractinfectionscausedbyChlamydiapneumoniaeinclude:SorethroatEarorsinusinfectionRunnyorstuffynoseFatigue(feelingtired)FeverHoarseness Lossofvoice(laryngitis)GraduallyworseningcoughthatmaylastforweeksormonthsHeadacheWhatCausesChlamydiaPneumoniae?ThebacteriaChlamydiapneumoniaedamagestheliningoftherespiratorytractincludingthethroat,windpipe,andlungs,causingrespiratorytractinfectionssuchaspneumoniaandbronchitis.C.pneumoniaeisspreadwheninfectedpeoplecoughorsneeze,releasingsmallrespiratorydropletsthatcontainthebacteriathatcanbeinhaledbyothersnearby.Touchingsomethingcoveredwithdropletsfromasickperson’scoughorsneeze,thentouchingone’smouthornosecanalsoresultininfection.ItiscommonforC.pneumoniaetospreadamongpeoplewholivetogether. People

NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListHHSAuthorManuscriptsPMC6345537ForImmunopatholDisTherap.Authormanuscript;availableinPMC2019Jan24.Publishedinfinaleditedformas:ForImmunopatholDisTherap.2016;7(3-4):237–254.doi: 10.1615/ForumImmunDisTher.2017020161PMCID:PMC6345537NIHMSID:NIHMS1007353PMID:30687565ChlamydiapneumoniaeInfectionandInflammatoryDiseasesRebeccaA.PorrittandTimothyR.Crother*AuthorinformationCopyrightandLicenseinformationDisclaimerDivisionofPediatricInfectiousDiseasesandImmunology,BurnsandAllenResearchInstitute,Cedars-SinaiMedicalCenter,LosAngeles,CA90048*Addressallcorrespondenceto:TimothyR.Crother,Ph.D.;AssistantProfessorofPediatrics,DivisionofPediatricInfectiousDiseasesandImmunology,Cedars-SinaiMedicalCenter,8700BeverlyBlvd.,Room4221,LosAngeles,CA90048;Tel.:(310)423-7970;Fax:(310)423-8284,gro.shsc@rehtorc.yhtomitCopyrightnoticeSeeotherarticlesinPMCthatcitethepublishedarticle.Chlamydiapneumoniae,anobligateintracellularbacterialpathogen,haslongbeeninvestigatedasapotentialdevelopmentalorexacerbatingfactorinvariouspathologies.Itsuniquelifestyleandabilitytodisseminatethroughoutthehostwhilepersistinginrelativesafetyfromtheimmuneresponsehasplacedthisobligateintracellularpathogeninthecrosshairsasapotentiallymitigatingfactorinchronicinflammatorydiseases.ManyanimalmodelandhumancorrelativestudieshavebeenperformedtoconfirmordenyaroleforC.pneumoniaeinfectioninthesedisorders.Insomecases,antibioticclinicaltrialswereconductedtoprovealinkbetweenbacterialinfectionsandatherosclerosis.Inthisreview,wedetailthelatestinformationregardingthepotentialrolethatC.pneumoniaeinfectionmayhaveinchronicinflammatorydiseases.Keywords:Alzheimer’s,arthritis,asthma,atherosclerosis,cancer,ChlamydiapneumoniaeChlamydiapneumoniaeisanobligateintracellularbacterialpathogenthatinfectstherespiratorytract.ThemajorityofindividualsareexposedtoC.pneumoniaethroughouttheirlifetimeswithanantibodypr