The median progression free survival, 1.5 years for CHOP versus not reached for R-CHOP, and the median overall survival (OS) was 3.1 years for CHOP and not ...Home»DecisionSupportinMedicine»HematologyDiffuselargeBcelllymphomaWhateveryphysicianneedstoknow:DiffuselargeB-celllymphoma(DLBCL)isanaggressivelymphomathatispotentiallycurable.DLBCListhemostcommonnon-Hodgkinlymphoma(NHL)representingabout30%ofallcasesofNHLintheUnitedStatesofAmerica(USA)andEurope.Thereareover76differenttypesoflymphoma.Itisessentialtoestablishthecorrecthistologicaldiagnosispriortotreatment.Theprognosisisdefinedbyfiveindependentprognosticfactors:age,performancescore,lactatedehydrogenase(serum),extranodalsites,andstage(APpLES),whichassignsindividualpatientstolow,low/intermediate,high/intermediate,orhigh.Althoughthiswasdevelopedbeforetherituximabera,thisriskfactorstratificationremainspredictiveintheimmunochemotherapyera.Theadditionofrituximabtochemotherapyandimmunochemotherapy,changedthenaturalhistoryofDLBCL.NewbiologicobservationsarecontributingtonewapproachestoDLBCL.AreyousureyourpatienthasdiffuselargeBcelllymphoma?Whatshouldyouexpecttofind?Themostcommonpresentationispainlesslymphadenopathyinapatientwithnoaccompanyingsymptoms.Patientsmaypresentwithextranodaldisease.Thesymptomsoflymphomaincludetheclassical“B”symptomsoffevers,nightsweats,andweightloss.Othersymptomsrelatetothelocationofthedisease.BewareofotherconditionsthatcanmimicdiffuselargeBcelllymphoma:Thedifferentialdiagnosisoflymphadenopathybroadlyincludescancers,hypersensitivitysyndromes,infections,connectivetissuediseases,atypicallymphoproliferativedisorders,granulomatousdisorders,andotherunusualcauses.Therearemorethan158causesoflymphadenopathyasbroadlyclassified.AnacronymforthisisCHICAGO.Themalignantcausesincludethehematologicmalignanciesincludingothernon-Hodgkinlymphomas,Hodgkinlymphoma,acuteandchronicleukemias,andotherdisordersandsolidtumorsincludingbreastcancer,lungcancer,renalcellcarcioma,prostatecancer,andothers.Thereareover76differentt

Data suggest that 5-year survival rates in diffuse large cell lymphoma are higher for white persons than they are for people of African descent, ...ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointSpecialty:MultispecialtyAllergy&ImmunologyAnesthesiologyBusinessofMedicineCardiologyCriticalCareDermatologyDiabetes&EndocrinologyEmergencyMedicineFamilyMedicineGastroenterologyGeneralSurgeryHematology-OncologyHIV/AIDSHospitalMedicineInfectiousDiseasesInternalMedicineMultispecialtyNephrologyNeurologyOb/Gyn&Women'sHealthOncologyOphthalmologyOrthopedicsPathology&LabMedicinePediatricsPlasticSurgeryPsychiatryPublicHealthPulmonaryMedicineRadiologyRheumatologyTransplantationUrologyMedicalStudentsNursesPharmacistsResidentsTodayonMedscapeEdition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSLogInSignUpIt'sFree!Edition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSRegisterLogInNoResultsNoResultsTuesday,October19,2021ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointclosePleaseconfirmthatyouwouldliketologoutofMedscape.Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit.LogoutCancelhttps://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cDovL3d3dy5tZWRzY2FwZS5jb20vYW5zd2Vycy8yMDI5NjktMTg4MTEyL3doYXQtaXMtdGhlLXByb2dub3Npcy1vZi1kaWZmdXNlLWxhcmdlLWItY2VsbC1seW1waG9tYS1kbGJjbA==processing....Drugs&Diseases>Hematology>DiffuseLargeB-CellLymphoma(DLBCL)Q&AWhatistheprognosisofdiffuselargeB-celllymphoma(DLBCL)?Updated:Aug20,2020Author:ShipraGandhi,MBBS;ChiefEditor:EmmanuelCBesa,MD more...ReferencesShareEmailPrintFeedbackCloseFacebookTwitterLinkedInWhatsAppAnswerDatasuggestthat5-yearsurvivalratesin diffuselargecelllymphomaarehigherforwhitepersonsthantheyareforpeopleofAfricandescent,whichmayormaynotreflectsocioeconomicfactors.Womenalsohaveabettersurvivaloutcome,asdopatientsyoungerthan65years.[39]Theclinicaloutcomeoflymphomapatientshasimprovedoverthelastdecadesasaresultofseveralfactorsthatinclude

Most people with early-stage DLBCL (stage 1 or stage 2) are treated with a short course of chemotherapy or chemo-immunotherapy (chemotherapy given with antibody ...SkiptomaincontentDonateCallourhelplineHomeAboutlymphomaExpanddropdownCOVID-19andlymphomaWhatislymphoma?SymptomsoflymphomaTests,diagnosisandstagingTreatmentforlymphomaSideeffectsoftreatmentLivingwithandbeyondlymphomaRelationshipsandcaringLymphomaandtheendoflifeUsefulorganisationsGlossaryTypesoflymphomaExpanddropdownHodgkinlymphomaNon-HodgkinlymphomaChroniclymphocyticleukaemia(CLL)SkinlymphomaLymphomainchildrenandyoungpeopleCNSlymphomaOtherrarehigh-gradeB-celllymphomasPost-transplantlymphoproliferativedisorderLymphomaandHIVTransformationoflymphomaSupportforyouExpanddropdownContactusforsupport(helplineservices)OnlineservicesandsupportOnlinesupportmeetingsLymphomaVoices(podcasts)BuddyServiceLiveyourLife(selfmanagement)Wellbeing(videosandtoolkit)BooksandinformationAccessibleinformationLymphomaMattersmagazinePersonalstoriesLymphomaTrialsLink(clinicaltrialsdatabase)HealthcareprofessionalsExpanddropdownLymphomatreatmentandCOVID-19forhealthcareprofessionalsCOVID-19vaccinationinpatientswithlymphomaEducationandtrainingLymphomaEducationforNursesSignupforeducationandtrainingupdatesResearchprojectsandreportsInformationandresourcesforpatientsSupportforyourpatientsLymphomaTrialsLinkGP/PrimarycaretrainingcoursesGetinvolvedExpanddropdownChristmas2021FundraisefromhomeTakepartinaneventDonateinmemoryLeaveagiftinyourwillLotteriesandPrizeDrawsCampaigningCorporatefundraisingVolunteeringSignuptohearfromusShopAboutusEventsNewsOurpublicationsContactustwitterTwitterfacebookFacebookinstagramInstagramyoutubeYoutubeWhatisdiffuselargeB-celllymphoma(DLBCL)?Lymphomaisatypeofbloodcancerthatdevelopswhenwhitebloodcellscalledlymphocytesgrowoutofcontrol.Lymphocytesarepartofyourimmunesystem.Theytravelaroundyourbodyinyourlymphaticsystem,helpingyoufightinfections.Therearetwotypesoflymphocyte:Tlymphocytes(Tcells)andBlymphocytes(Bcells). Therearelo

Treatment for diffuse large B-cell lymphoma (DLBCL)SearchLinkedinCloseMenuDonateTypesofLymphomaHodgkinLymphomaClassicalHodgkinlymphoma(CHL)NodularlymphocytepredominantHodgkinlymphoma(NLPHL)Non-HodgkinLymphomaIndolent(slow-growing)B-cellNHLFollicularLymphomaMarginalzonelymphoma(MZL)Maltlymphoma(ML)Spleniclymphoma(SL)Nodallymphoma(NL)Waldenstrom’smacroglobulinemia(WM)HairyCellLeukaemiaAggressive(fast-growing)B-cellNHLDiffuseLargeBcell(DLBCL)DoublehitandTriplehit(DL&TL)PrimaryMediastinalB–celllymphoma(PMBCL)GreyZonelymphoma(GZL)BurkittLymphoma(BL)Mantlecelllymphoma(MCL)Lymphoblasticlymphoma(LL)LymphomaTcellAdultT-cellleukaemia-lymphoma(ATLL)Anaplasticlargecelllymphoma(ALCL)AngioimmunoblasticT-celllymphoma(AITL)EnteropathytypeintestinalT-celllymphomaHepatosplenicgammadeltaT-celllymphomaNasalnaturalkiller(NK)T-celllymphomaPeripheralT-celllymphoma(PTCL)PeripheralT-celllymphoma–nototherwisespecified(PTCL-NOS)SkinLymphomaCutaneousT-celllymphoma(CTCL)CutaneousB-celllymphoma(CBCL)Mycosisfungoides(MF)SezarySyndromeChroniclymphocyticleukaemia(CLL)MonoclonalB-celllymphocytosis(MBL)CNSLymphomaTransformedLymphomaRelapsedandRefractoryLymphomaChildren&YoungAdultsLymphomainChildrenHodgkinlymphomaBurkittlymphomaAnaplasticlargecelllymphoma–inchildrenPracticaltipsforparentsandcarersDiffuselargeB-celllymphoma(DLBCL)inchildrenLymphoblasticlymphomainchildrenOtherLymphomaTypesClickheretoviewotherlymphomatypesTypesofLymphoma/Non-HodgkinLymphoma/Aggressive(fast-growing)B-cellNHL/DiffuseLargeBcell(DLBCL)DiffuseLargeBcell(DLBCL)DiffuselargeB-celllymphoma(DLBCL)isthemostcommontypeofnon-Hodgkinlymphoma.DLBCLisanaggressive(fast-growing)lymphomaandhasagoodchanceofbeingcured.Onthispage:DiffuseLargeBCellLymphoma(DLBCL)FactSheetPDFDownloadOverviewofdiffuselargeB-celllymphoma(DLBCL)DiffuselargeB-celllymphoma(DLBCL)isanaggressive(fast-growing)B-cellnon-Hodgkinlymphoma. Itisthemostcommonsubtypeoflymphoma,accountingforaround30%ofalllymphomacasesandaffectsaround2,000Australianseachyear.Whyisitcalleddiffuse

Prognosis and survival rates ... Two-thirds of people with DLBCL who are treated can be cured. However, if it's left untreated, it can lead to death. Most people ...HealthConditionsDiscoverPlanConnectSubscribeDiffuseLargeB-CellLymphomaMedicallyreviewedbyChristinaChun,MPH—WrittenbyDianaWells—UpdatedonSeptember18,2018SymptomsCausesandriskfactorsPrognosisandsurvivalratesTreatmentDiagnosisOutlookOverviewDiffuselargeB-celllymphoma(DLBCL)isatypeofbloodcancer.Lymphomasarethemostcommontypeofbloodcancers.Therearetwotypesoflymphoma:Hodgkin’sandnon-Hodgkin’s.DiffuselargeB-celllymphomaisanon-Hodgkin’slymphoma(NHL).Outofover60typesofNHLs,diffuselargeB-celllymphomaisthemostcommon.DLBCListhemostaggressiveorfast-growingformofNHL.Itcanleadtodeathifleftuntreated.Alllymphomas,includingDLBCL,affecttheorgansofyourlymphaticsystem.Thelymphaticsystemiswhatallowsyourbodytofightinfections.TheorgansthatcanbeaffectedbylymphomassuchasDLBCLincludethefollowing:bonemarrowthymusspleenlymphnodesThefollowingfeaturesarewhatmakeaDLBCLdifferentthanotherlymphomas:ItcomesfromabnormalB-cells.TheseB-cellsarelargerthannormalB-cells.TheabnormalB-cellsarespreadoutinsteadofgroupedtogether.TheabnormalB-cellswilldestroythestructureofthelymphnode.ThemaintypeofDLBCListhemostcommonofallDLBCLtypes.However,therearesomelesscommontypesyoumaywanttobeawareof.TheselesscommontypesofDLBCLare:centralnervoussystemlymphomaT-cell/histiocyte-richlargeB-celllymphomaEBV-positiveDLBCLprimarymediastinal(thymic)largeB-celllymphomaintravascularlargeB-celllymphomaALK-positivelargeB-celllymphomaWhatarethesymptoms?ThefollowingaretheprimarysymptomsyoumayexperiencewithDLBCL:enlargedlymphnodesnightsweatsunusualweightlosslossofappetiteextremetirednessorfatiguefeverextremeitchinessYoumayexperiencecertainothersymptomsdependingonthelocationofyourDLBCL.Theseadditionalsymptomsmayinclude:abdominalpain,diarrhea,bloodinstoolsacoughandshortnessofbreathWhatarethecausesandriskfactors?Alymphomaoccurswhenlymphocytesbegintogrowanddivide,orreproduce,quickly

Diffuse large B cell lymphoma (DLBCL) is the commonest subtype of non-Hodgkin's lymphoma accounting for approximately 30–50 % of cases [1].NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListSpringerOpenChoicePMC4374121AnnalsofHematologyAnnHematol.2015;94(5):803–812.Publishedonline2014Dec14.doi: 10.1007/s00277-014-2271-1PMCID:PMC4374121PMID:25501975PrognosisofpatientswithdiffuselargeBcelllymphomanotreachingcompleteresponseorrelapsingafterfrontlinechemotherapyorimmunochemotherapyJordinaRovira,1AlexandraValera,2LluisColomo,2XavierSetoain,3SoniaRodríguez,4AlejandraMartínez-Trillos,1EvaGiné,1IvanDlouhy,1LauraMagnano,1AnnaGaya,1DanielMartínez,2AntonioMartínez,2ElíasCampo,2andArmandoLópez-Guillermo1JordinaRovira1HematologyDepartment,HospitalClínic,IDIBAPS,C/.Villarroel,170,08036Barcelona,SpainFindarticlesbyJordinaRoviraAlexandraValera2PathologyDepartment,HospitalClínic,IDIBAPS,UniversityofBarcelona,Barcelona,SpainFindarticlesbyAlexandraValeraLluisColomo2PathologyDepartment,HospitalClínic,IDIBAPS,UniversityofBarcelona,Barcelona,SpainFindarticlesbyLluisColomoXavierSetoain3NuclearMedicineDepartment,HospitalClínic,Barcelona,SpainFindarticlesbyXavierSetoainSoniaRodríguez4RadiologyDepartment,HospitalClínic,Barcelona,SpainFindarticlesbySoniaRodríguezAlejandraMartínez-Trillos1HematologyDepartment,HospitalClínic,IDIBAPS,C/.Villarroel,170,08036Barcelona,SpainFindarticlesbyAlejandraMartínez-TrillosEvaGiné1HematologyDepartment,HospitalClínic,IDIBAPS,C/.Villarroel,170,08036Barcelona,SpainFindarticlesbyEvaGinéIvanDlouhy1HematologyDepartment,HospitalClínic,IDIBAPS,C/.Villarroel,170,08036Barcelona,SpainFindarticlesbyIvanDlouhyLauraMagnano1HematologyDepartment,HospitalClínic,IDIBAPS,C/.Villarroel,170,08036Barcelona,SpainFindarticlesbyLauraMagnanoAnnaGaya1HematologyDepartment,HospitalClínic,IDIBAPS,C/.Villarroel,170,08036Barcelona,SpainFindarticlesbyAnnaGayaDanielMartínez2PathologyDepartment,

Diffuse large B cell lymphoma (DLBCL) is the most common histologic subtype of non-Hodgkin lymphoma (NHL), accounting for approximately 25 ...

SkiptomaincontentHomeAboutcancerNon-HodgkinlymphomaTypesandgradesDiffuselargeBcelllymphomaDiffuselargeBcelllymphoma(DLBCL)isatypeofnon-Hodgkinlymphoma(NHL).NHLisacancerofthelymphaticsystem. ItdevelopswhenthebodymakesabnormalBlymphocytes.Theselymphocytesareatypeofwhitebloodcellthatnormallyhelptofightinfections. Whenyouhavealymphoma,theabnormallymphocytesbuildupinlymphnodesorotherbodyorgans. DLBCL growsquicklyandyourtreatmentstartssoonafterdiagnosis.ThelymphaticsystemThelymphaticsystemisanimportantpartofourimmunesystem.Ithastubesthatbranchthroughallpartsofthebody.Thesetubesarecalledlymphvesselsorlymphaticvesselsandtheycarryastrawcolouredliquidcalledlymph.Thisliquidcirculatesaroundthebodytissues.Itcontainsahighnumberofwhitebloodcells(lymphocytes)whichfightinfection.Whenyouhavelymphoma,someofyourwhitebloodcells(lymphocytes)don'tworkproperly.Theystarttodivideconstantlybutdon'tdevelopfully.Sotheycan'tfightinfectionasnormalwhitebloodcellsdo.TherearedifferenttypesofNHL.Thetypeyouhavedependsonseveralfactorsincludingthetypeofcellitstartsinandhowfastgrowingitis.Therearetwomaintypesoflymphocytes–BcellsandTcells.Theybothhelpusfightinfectionsbutinslightlydifferentways.DLBCL affectstheBcellsandsoiscalledaBcelllymphoma.Howcommonisit?Eachyearabout5,500peoplearediagnosedwithDLBCL.Thismakesupabout40outof100cases(40%)ofNHLinadults.DLBCL ismorecommoninmalesthanfemales.TypesofdiffuselargeBcelllymphoma(DLBCL)Asthenamesuggests,diffuselargeBcelllymphoma(DLBCL)meansthistypeoflymphomahas:abnormalandenlargedBcells(atypeofwhitebloodcell)cancercellsinaspreadout(diffuse)patternTherearesomedifferentsubtypesofDLBCL.Somesubtypesarequiterare,butmosttypesaretreatedinasimilarway.Theseraretypesinclude:T-cell/histiocyte-richlargeB-celllymphoma  EpsteinBarrviruspositiveDLBCLoftheelderlyALKpositivelargeBcelllymphomaprimarymediastinal(thymic)largeBcelllymphomaintravascularlargeBcelllymphomaSymptomsSymptomscanstartorgetworseinjustafewweeks.PainlessswellingsThemostcommonsymptomisoneormorepainlessswellings.The

SkiptocontentSelectlanguage: SelectLanguageArabicChinese(Simplified)DutchEnglishFrenchGermanHindiItalianJapaneseKoreanPortugueseRussianSpanishTamilUrduVietnamese1800620420ClosemenuSearchHomeBloodcancerinformationTypesofbloodcancerLymphomaNon-HodgkinlymphomaDiffuselargeB-celllymphomaDiffuselargeB-celllymphomaListenWhatisdiffuselargeB-celllymphoma(DLBCL)?DiffuselargeB-celllymphoma(DLBCL)isanaggressivetypeofnon-HodgkinlymphomathatdevelopsfromtheB-cellsinthelymphaticsystem.Underthemicroscope,largemalignantlymphocytesareseendiffuselythroughoutthespecimen.DLBCListhemostcommonsubtypeofnon-Hodgkinlymphomaaccountingfor30%-40%ofallcases.ThereareseveraltypesofDLBCL,withmostpeoplebeingdiagnosedwiththesubtypeknownasDLBCL‘nototherwisespecified’.Rarertypesinclude:PrimarymediastinallargeB-celllymphoma:accountsfor2-4%ofallnon-Hodgkinlymphomas.Canoccuratanytimefromearlyadulthood,butismostcommonbetween25-40yearsofage.Itistwiceascommoninwomenasinmen.Developsinthemediastinum(inthechest)andcancauseproblemsduetothepressureofthemassonthelungsorgut,oronthesuperiorvenacava(thesecondlargestveininthebodywhichreturnsbloodfromtheupperhalfofthebodytotheheart).Symptomsincludebreathlessness,persistentcough,difficultyswallowing(dysphagia),swellingoftheneckandface,dizzinessandheadaches.Treatmentinvolvestheuseofatargetedtherapyplusstandardchemotherapy,oftenfollowedbyradiotherapyorhigh-dosechemotherapyregimens.Stemcelltransplantsmaybeofferedifthistypeoflymphomarelapses.T-cell/histiocyte-richlargeB-celllymphoma:morecommoninmenagedover50yearsbutcanaffectpeopleofanyage.Fewerthan10%ofpeoplewithDLBCLwillhavethistype.ThistypeofDLBCLhasallthreetypesofcellspresent-T-cells,histiocytesandlargeB-cells,whenviewingabiopsyspecimenunderthemicroscope.Symptomsincludeswollenlymphnodes,feverandswellingoftheliverorspleen.PeoplewiththistypeofDLBCLwillfeelgenerallyunwellandhaveabdominalswellinganddiscomfort.TreatmentissimilartothatofthemorecommontypesofDLBCL(suchasatargetedtherapyplusstandardchemotherapy).Ifitrelapses,theot

TogglenavigationCOVID-19AboutAboutTheASCOPostEditorialBoardRightsandPermissionsContactSubscribeNewsFDAUpdateJournalSpotlightExpert'sCornerIntheClinicViewByIssueViewAllMeetingsAACR-NCI-EORTCVirtualInternationalConferenceonMolecularTargetsandCancerTherapeutics14thAACRConferenceontheScienceofCancerHealthDisparitiesinRacial/EthnicMinoritiesandtheMedicallyUnderserved2021ASCOQualityCareSymposiumESMOCongress2021SOHO2021CalendarViewAllTopicsBreastCancerLungCancerProstateCancerLymphomaViewAllVideosNewsreelsVideoRoundtablesPodcastsSubscribeAdvertisementChallengesofManagingOlderPatientsWithDiffuseLargeB-CellLymphomaByColetteN.Owens,MDSeptember10,2018AdvertisementColetteN.Owens,MDAsthepopulationcontinuestoage,theinterplaybetweenagingandcancerincreasinglyshowscancertobeadiseaseofolderpeople.Bytheyear2030,therewillbeanincreasedincidenceofnon-Hodgkinlymphoma(NHL)inolderindividuals.1ThemedianageofpatientsdiagnosedwithdiffuselargeB-celllymphoma(DLBCL)is70yearsold,andgiventhesedemographicchanges,oncologistswillincreasinglyberequiredtomanageolderpatientswithDLBCLinthecontextofcomorbidityandage-relatedorgandysfunction.DLBCLisanaggressiveNHLthatiscurablewithfront-linetherapywithananthracycline-basedchemoimmunotherapy,withoverallsurvivalratesof60%to70%.2,3However,thisrepresentsthebestopportunityforcure,asthosewithrelapsedorrefractorydiseaseoftendieofthedisease.StuartM.Lichtman,MDGiventhiscontext,therearesignificantchallengesinoptimizingtherapyforolderpatientsinthecontextofdiseaseandpatientfactors.Fromapracticalstandpoint,theinitialassessmentofolderpatientswithDLBCLisevolvingnotonlytoincludediseasestagingandbiologicriskfactors,butalsooncogeriatricriskassessments.LifeExpectancyCONSIDERATIONOFlifeexpectancyisimportantinchoosingatherapyforolderpatients.Theaverage80-year-oldhasapredictedlifeexpectancyofapproximately5years,andthus,DLBCLismostlikelythegreatestrisktothepatient,exceptforthefrailestpatientswithalifeexpectancyoflessthan1year.4GUESTEDITORGeriatricsfortheOncologistisguesteditedbyStua