Prognosis and survival rates ... Two-thirds of people with DLBCL who are treated can be cured. However, if it's left untreated, it can lead to death. Most people ...HealthConditionsDiscoverPlanConnectSubscribeDiffuseLargeB-CellLymphomaMedicallyreviewedbyChristinaChun,MPH—WrittenbyDianaWells—UpdatedonSeptember18,2018SymptomsCausesandriskfactorsPrognosisandsurvivalratesTreatmentDiagnosisOutlookOverviewDiffuselargeB-celllymphoma(DLBCL)isatypeofbloodcancer.Lymphomasarethemostcommontypeofbloodcancers.Therearetwotypesoflymphoma:Hodgkin’sandnon-Hodgkin’s.DiffuselargeB-celllymphomaisanon-Hodgkin’slymphoma(NHL).Outofover60typesofNHLs,diffuselargeB-celllymphomaisthemostcommon.DLBCListhemostaggressiveorfast-growingformofNHL.Itcanleadtodeathifleftuntreated.Alllymphomas,includingDLBCL,affecttheorgansofyourlymphaticsystem.Thelymphaticsystemiswhatallowsyourbodytofightinfections.TheorgansthatcanbeaffectedbylymphomassuchasDLBCLincludethefollowing:bonemarrowthymusspleenlymphnodesThefollowingfeaturesarewhatmakeaDLBCLdifferentthanotherlymphomas:ItcomesfromabnormalB-cells.TheseB-cellsarelargerthannormalB-cells.TheabnormalB-cellsarespreadoutinsteadofgroupedtogether.TheabnormalB-cellswilldestroythestructureofthelymphnode.ThemaintypeofDLBCListhemostcommonofallDLBCLtypes.However,therearesomelesscommontypesyoumaywanttobeawareof.TheselesscommontypesofDLBCLare:centralnervoussystemlymphomaT-cell/histiocyte-richlargeB-celllymphomaEBV-positiveDLBCLprimarymediastinal(thymic)largeB-celllymphomaintravascularlargeB-celllymphomaALK-positivelargeB-celllymphomaWhatarethesymptoms?ThefollowingaretheprimarysymptomsyoumayexperiencewithDLBCL:enlargedlymphnodesnightsweatsunusualweightlosslossofappetiteextremetirednessorfatiguefeverextremeitchinessYoumayexperiencecertainothersymptomsdependingonthelocationofyourDLBCL.Theseadditionalsymptomsmayinclude:abdominalpain,diarrhea,bloodinstoolsacoughandshortnessofbreathWhatarethecausesandriskfactors?Alymphomaoccurswhenlymphocytesbegintogrowanddivide,orreproduce,quickly