Challenges of Managing Older Patients With Diffuse Large B-Cell ... | Diffuse large B-cell lymphoma prognosis
TogglenavigationCOVID-19AboutAboutTheASCOPostEditorialBoardRightsandPermissionsContactSubscribeNewsFDAUpdateJournalSpotlightExpert'sCornerIntheClinicViewByIssueViewAllMeetingsAACR-NCI-EORTCVirtualInternationalConferenceonMolecularTargetsandCancerTherapeutics14thAACRConferenceontheScienceofCancerHealthDisparitiesinRacial/EthnicMinoritiesandtheMedicallyUnderserved2021ASCOQualityCareSymposiumESMOCongress2021SOHO2021CalendarViewAllTopicsBreastCancerLungCancerProstateCancerLymphomaViewAllVideosNewsreelsVideoRoundtablesPodcastsSubscribeAdvertisementChallengesofManagingOlderPatientsWithDiffuseLargeB-CellLymphomaByColetteN.Owens,MDSeptember10,2018AdvertisementColetteN.Owens,MDAsthepopulationcontinuestoage,theinterplaybetweenagingandcancerincreasinglyshowscancertobeadiseaseofolderpeople.Bytheyear2030,therewillbeanincreasedincidenceofnon-Hodgkinlymphoma(NHL)inolderindividuals.1ThemedianageofpatientsdiagnosedwithdiffuselargeB-celllymphoma(DLBCL)is70yearsold,andgiventhesedemographicchanges,oncologistswillincreasinglyberequiredtomanageolderpatientswithDLBCLinthecontextofcomorbidityandage-relatedorgandysfunction.DLBCLisanaggressiveNHLthatiscurablewithfront-linetherapywithananthracycline-basedchemoimmunotherapy,withoverallsurvivalratesof60%to70%.2,3However,thisrepresentsthebestopportunityforcure,asthosewithrelapsedorrefractorydiseaseoftendieofthedisease.StuartM.Lichtman,MDGiventhiscontext,therearesignificantchallengesinoptimizingtherapyforolderpatientsinthecontextofdiseaseandpatientfactors.Fromapracticalstandpoint,theinitialassessmentofolderpatientswithDLBCLisevolvingnotonlytoincludediseasestagingandbiologicriskfactors,butalsooncogeriatricriskassessments.LifeExpectancyCONSIDERATIONOFlifeexpectancyisimportantinchoosingatherapyforolderpatients.Theaverage80-year-oldhasapredictedlifeexpectancyofapproximately5years,andthus,DLBCLismostlikelythegreatestrisktothepatient,exceptforthefrailestpatientswithalifeexpectancyoflessthan1year.4GUESTEDITORGeriatricsfortheOncologistisguesteditedbyStua
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Small B-cell lymphomaDiffuse large B cell lymphoma stageDiffuse large B-cell lymphoma NCCNDiffuse large B cell lymphoma stagingDiffuse large B-cell lymphoma relapse rateDiffuse large B-cell lymphoma brain metastasesLymphoma prognosis