Rhabdomyosarcoma pathology outlines延伸文章資訊,搜尋引擎最佳文章推薦
1. Rhabdomyosarcoma
A malignant tumor of the primitive mesenchyme. it is the most common sarcoma in children · Four sub-types of rhabdomyosarcoma. Embryonal.PathologyPathologyIntroductionHigh-YieldTopicsBoneTumorStagingSystemsImpendingFracture&ProphylacticFixationBiopsyPrinciplesChemotherapyRadiationTherapyDifferentialGroupsBoneTumorsOsteogenicTumorsOsteoidOsteomaOsteoblastomaIntramedullaryOsteosarcomaParostealOsteosarcomaPeriostealOsteosarcomaTelangiectaticOsteosarcomaChondrogenicTumorsEnchondromasPeriostealChondromasOsteochondroma&MultipleHereditaryExostosisChondroblastomaChondromyxoidFibromaChondrosarcomaHematopoieticMultipleMyelomaLymphomaLeukemiaFibrogenic&HistiocyticNon-OssifyingFibromaHistiocytoma(BenignFibrousHistiocytoma)DesmoplasticFibromaMalignantFibrousHistiocytoma(PleomorphicSarcoma)FibrosarcomaofBoneNotochordal&VascularChordomaHemangiomaHemangioendothelioma(hemangiosarcoma)ReactiveLesionsUnicameralBoneCystAneurysmalBoneCystTumor-likelesionsFibrousDysplasiaOsteofibrousDysplasiaPaget'sDiseaseEosinophilicGranulomaMyositisOssificansMelorheostosisHeterotopicOssificationTumoralCalcinosisBoneInfarctFocalFibrocartilaginousDysplasiaUnknownOrignGiantCellTumorEwing'sSarcomaAdamantinomaMetastaticdiseaseMetastaticDiseaseofExtremityMetastaticDiseaseofSpineSoftTissueTumorsSoftTissueSarcomaSoftTissueSarcomaSynovialTissuePigmentedVillonodularSynovitisSynovialChondromatosisSynovialSarcomaPeripheralNervesNeurilemmomaNeuromaMalignantPeripheralNerveSheathTumorNeurofibromaNeuroblastomaMuscleTumorsLeiomyosarcomaRhabdomyosarcomaFibrogenicCalicifyingAponeuroticFibromaPlantarFibromatosis(LedderhoseDisease)Extra-abdominalDesmoidTumorNodularFasciitisUndifferentiatedPleomorphicSarcomaFibrosarcomaofSoftTissueDermatofibrosarcomaProtuberansLipogenicLipomasLiposarcomaVascularTissueHemangiomaofSoftTissueAngiosarcomaDermatologicSquamousCellCarcinomaGlomusTumorActinicKeratosisBasalCellCarcinomaMelanomaOtherEpithelioidSarcomaIntramuscularMyxomasOtherPathologyTopicsUpdated:11/27/20208RhabdomyosarcomaPatrickO'
2. Rhabdomyosarcoma
Alveolar rhabdomyosarcoma · Alveolus-like pattern -- key low-power feature. Fibrous septae lined by tumour cells. Cells may "fall-off" the septa, i.e. be detached/ ...RhabdomyosarcomaFromLibrePathologyJumptonavigationJumptosearchRhabdomyosarcomaDiagnosisinshortAlveolarrhabdomyosarcoma.H&Estain.LM+/-rhabdomyoblasts(eccentricnucleus,moderateamountofintenslyeosinophiliccytoplasm,striations-notcommon);alveolarRMS:alveolus-likepattern(classic);embryonalRMS:smallroundcelltumourSubtypesembryonal(spindlecellsubtype,botryoid),alveolar(translocation-positive,translocation-negative),undifferentiatedLMDDxsmallroundcelltumours-esp.smallcellcarcinomaand(largecell)lymphomasIHCdesmin(bestmarker)+ve,actin+ve,myogenin+ve,CD56+ve(common),synaptophysin-ve/+ve,chromogranin-ve/+ve,cytokeratins-ve/+veEMsarcomericlikestructures-typicallyinU-shapedcellsMolecularalveolarRMS(~85%ofcases):t(2,13)PAX3/FKHRfusiongeneort(1,13)PAX7/FKHRfusiongeneSitesofttissue-skeletalmusclesite(alveolarRMS),non-skeletalmusclesite(embryonalRMS)ClinicalhistoryalveolarRMS:youngadultoradolescent;embryonalRMS:typically<10yearsoldPrevalencenotcommonClin.DDxothersofttissuetumoursRhabdomyosarcoma,oftenabbreviatedRMS,isamalignanttumourofskeletalmuscle.Contents1General1.1Classification1.1.1Histologic1.1.2Molecularandhistologic2Gross3Microscopic3.1Alveolarrhabdomyosarcoma3.1.1Images3.2Embryonalrhabdomyosarcoma3.2.1SubtypesofembryonalRMS3.3Anaplasia4IHC4.1SubtypingviaIHC5Electronmicroscopy6Moleculardiagnostics6.1Alveolarrhabdomyosarcoma6.2Embryonalrhabdomyosarcoma7Seealso8ReferencesGeneralMostcommonpaediatricsarcoma.Classicallyintheheadandneckregion.[1]MostcommonsarcomainLi-Fraumenisyndrome.[2]~6%ofallchildhoodcancer.ClassificationHistologicAlveolarrhabdomyosarcoma.Usuallyyoungadults/adolescents.Earlymetscommon.Usuallyarisesinregionswithskeletalmuscle.Embryonalrhabdomyosarcoma.Usual<10yearsold.Typicallylocallyinvasive.Usuallyarisesinregionswithoutskeletalmuscle.Lesscommontypes:[3]Undifferentiatedrhabdomyosarcoma.Botryoid-may
3. Classification of Rhabdomyosarcoma and Its Molecular Basis
NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListHHSAuthorManuscriptsPMC6637949AdvAnatPathol.Authormanuscript;availableinPMC2019Jul18.Publishedinfinaleditedformas:AdvAnatPathol.2013Nov;20(6):387–397.doi: 10.1097/PAP.0b013e3182a92d0dPMCID:PMC6637949NIHMSID:NIHMS541548PMID:24113309ClassificationofRhabdomyosarcomaandItsMolecularBasisDavidM.Parham,MD*andFredericG.Barr,MD,PhD†DavidM.Parham*DepartmentofPathology,UniversityofOklahomaHealthScienceCenter,OklahomaCity,OKFindarticlesbyDavidM.ParhamFredericG.Barr†LaboratoryofPathology,NationalCancerInstitute,Bethesda,MDFindarticlesbyFredericG.BarrAuthorinformationCopyrightandLicenseinformationDisclaimer*DepartmentofPathology,UniversityofOklahomaHealthScienceCenter,OklahomaCity,OK†LaboratoryofPathology,NationalCancerInstitute,Bethesda,MDReprints:DavidM.Parham,MD,DepartmentofPathology,UniversityofOklahomaHealthScienceCenter,940StantonL.YoungBlvd.,BMSB451,OklahomaCity,OK73104,ude.cshuo@mahrap-divadCopyrightnoticeThepublisher'sfinaleditedversionofthisarticleisavailableatAdvAnatPatholSeeotherarticlesinPMCthatcitethepublishedarticle.Rhabdomyosarcoma,themostcommonsofttissuesarcomaofchildren,hastraditionallybeenclassifiedintoembryonalrhabdomyosarcoma(ERMS)andalveolarrhabdomyosarcoma(ARMS)forpediatriconcologypractice.Thisreviewoutlinesthehistoricaldevelopmentofclassificationofchildhoodrhabdomyosarcomaandthechallengesthathavebeenassociatedwithit,particularlyproblemswiththediagnosisof“solidvariant”ARMSanditsdistinctionfromERMS.Inadditiontodifferencesinclinicalpresentationandoutcome,anumberofgeneticfeaturesunderpinseparationofERMSfromARMS.GeneticdifferencesassociatedwithrhabdomyosarcomasubclassificationincludethepresenceofreciprocaltranslocationsandtheirassociatedfusionsinARMS,amplificationofgenesinARMSanditsfusionsubsets,chromosomallossesandgainsthatmostlyoccurinERMS,andalleliclossesandmutationsusuallyassociatedwithERMS.ChimericproteinsencodedfromthefusionofPAX3orPAX7withFOXO1areexp
4. Rhabdomyosarcoma
SkiptoContentSearchMenuYouarehereHome>TypesofCancer>Rhabdomyosarcoma-Childhood>Rhabdomyosarcoma-Childhood:StatisticsRhabdomyosarcoma-Childhood:StatisticsApprovedbytheCancer.NetEditorialBoard,02/2021ONTHISPAGE: Youwillfindinformationaboutthenumberofchildrenandteenswhoarediagnosedwithrhabdomyosarcomaeachyear.Youwillalsoreadgeneralinformationonsurvivingthedisease.Remember,survivalratesdependonseveralfactors.Usethemenutoseeotherpages.About400to500peoplearediagnosedwithrhabdomyosarcomaeachyear.Mostpeoplewhoarediagnosedwithrhabdomyosarcomaarechildrenorteens.Morethanhalfofchildhoodrhabdomyosarcomasarediagnosedinthoseunderage10.EachyearintheUnitedStates,rhabdomyosarcomaaccountsfor3%ofcancersinchildrenages0to14and1%ofcancersinteensages15to19.Itisthemostcommonsoft-tissuesarcomainchildren.Boysareslightlymorelikelytodevelopthediseasethangirls.The5-yearsurvivalratetellsyouwhatpercentofchildrenandteensliveatleast5yearsafterthecancerisfound.Percentmeanshowmanyoutof100.The5-yearsurvivalrateforchildrenyoungerthan15is70%overall.The5-yearsurvivalrateforteensages15to19is46%.However,theratevarieswidelydependingonthetumorlocation,stageandriskgroup,andthechild’sage.Childrenages1to9haveabetterprognosisthanpeopleinotheragegroups.The5-yearsurvivalrateforchildrenwhohavelow-riskrhabdomyosarcomarangesfrom70%tomorethan90%.The5-yearsurvivalrateforchildrenintheintermediate-riskgrouprangesfromabout50%to70%.Whenthecancerbecomeshighrisk,spreadingwidelyinthebody,the5-yearsurvivalraterangesfrom20%to30%. Itisimportanttorememberthatstatisticsonthesurvivalratesforchildrenandteenswithrhabdomyosarcomaareanestimate.TheestimatecomesfromannualdatabasedonthenumberofchildrenandteenswiththiscancerintheUnitedStates.Also,expertsmeasurethesurvivalrateevery5years.Sotheestimatemaynotshowtheresultsofbetterdiagnosisortreatmentavailableforlessthan5years.Talkwithyourchild’sdoctorifyouhaveanyquestionsaboutthisinformation.Learnmoreabout understandingstatistics.StatisticsadaptedfromtheAmericanCancerSocietywebsiteandSeigelR,e
5. Pleomorphic Rhabdomyosarcoma in Adults: A ...
SkiptomaincontentThankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtainthebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodeinInternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstylesandJavaScript.AdvertisementnaturemodernpathologyoriginalarticlearticlePleomorphicRhabdomyosarcomainAdults:AClinicopathologicStudyof38CaseswithEmphasisonMorphologicVariantsandRecentSkeletalMuscle-SpecificMarkersDownloadPDFAbstractPleomorphicrhabdomyosarcoma(PRMS)isarareandcontroversialtumorofskeletalmusclephenotype.DiagnosticcriteriaforPRMSbycombinedhistologyandcurrentlyavailableimmunohistochemistryhavenotbeenclearlydefined.Wereport38pleomorphicrhabdomyosarcomasinadults,exploremorphologicvariants,anddiscussourexperiencewithbothspecificandnonspecificskeletalmusclemarkersinthesetumors.Clinicaldata,morphology,andimmunohistochemistrywerereviewed.Electronmicroscopywasperformed.Of38cases,therewere28malesand10females.Patientagesrangedfrom21to81years(median=54y;mean=51y).Tumorswerelocatedinthelowerextremity(n=18),abdomen/retroperitoneum(n=6),chest/abdominalwall(n=5),spermaticcord/testes(n=4),upperextremity(n=3),andoneeachinthemouthandorbit.Tumorsizesrangedfrom1.5to15.0cm(mean=7.3cm;median=6.8cm).Thecasesweredividedintothreevariants,eachwithlarge,atypical,pleomorphicpolygonalrhabdomyoblasts(PRMB)withabundanteosinophiliccytoplasminvaryingnumbersanddifferentmorphologicbackgroundsofroundorspindledrhabdomyoblasts(RMB).1.ClassicPRMS:PredominantlyatypicalPRMBinsheets(n=8).2.RoundcellPRMS:ClustersofPRMBthroughoutthetumorwithabackgroundofslightlyatypical,medium-sized,round,blueRMB(n=13).3.SpindlecellPRMS:ScatteredPRMBinapredominanceofatypicalspindledRMBarrangedinastoriformgrowthpattern(n=17).Immunohistochemistryrevealedthefollowing:myoglobin(37/38),MyoD1(19/36),skeletalmusclemyogenin(myf4;19/34),fastskeletalmusclemyosin(4/5),desmin(36/38),muscle-specificactin(MSA;25/35),smoothmuscleactin(SMA;15/33),andmuscl
6. Rhabdomyosarcoma
RhabdomyosarcomaHighQualityPathologyImagesofSoftTissue:MyogenicofRhabdomyosarcomaAdvertisementFollowus: 11065Images:LastWebsiteUpdate:March2,2021HomeAboutUsAcknowledgementsFeedbackContactUsSiteMapHighQualityPathologyImagesofBenignandMalignantNeoplasmsandRelatedEntitiesJanuary 2020RhabdomyosarcomaReviewers:JayalakshmiVenkateswaran,MD;DharamRamnani,MD|HomeSoftTissueMyogenicRhabdomyosarcomaRhabdomyosarcomas(RMS)aremalignantsofttissuetumors,exhibitingskeletalmuscledifferentiation.Thereisabimodalagedistribution,between2-6yearsandasecondpeakbetween10-18years;itisuncommonafter45years.Commonlocationsincludeheadandneck(26%),genitourinarytract(17%)andextremities(15%).Therearefourmajorsubtypes-Embryonal,Alveolar,Pleomorphic,&SpindleCell/Sclerosing.SarcomabotryoidesisavariantofEmbryonalRMS.Grossly,theirsizeisvariableandtheymaybewell-circumscribedandmultinodularorlesswelldefinedwithinfiltrativeborders.Sectioningrevealsglistening,gelatinous(mucoid)orgray-whiteorpink-tanfleshyandbulgingappearance.Areasofcystformation,hemorrhageornecrosismaybepresent.Microscopically,thetumorcellsrangefromsmallprimitivehyperchromaticround/spindle/stellatecellstolargedifferentiatedstrap/ribbon/tadpole/racket-shapedcellswithabundanteosinophiliccytoplasmandcross-striations(rhabdomyoblasts).Thenucleiarelarge,round,andvesicularwithaprominentnucleolus.Immunohistochemically,theyarepositiveforMyoD1,MyogeninA,MuscleSpecificActin(MSA)orDesmin.Translocationt(2;13)(q35;q14)isfoundinthemajorityofalveolarRMScasesandat(1;13)(p36;q14)isnotedinasmallersubset.Thecongenital/infantileformofsclerosing/spindlecellRMShasgenefusionsinvolvingVGLL2andNCOA2orCITED2genes.UsuallyRMSistreatedwithsurgeryandchemotherapy,withorwithoutradiationtherapy.Thehistologictypeandlocationofthetumorinfluencesurvival.ThebotryoidvariantofembryonalRMShasthebestprognosis,whilethepleomorphicsubtypeisoftenfatal.References:1)Goldblum,J.R.,Weiss,S.W.,&Folpe,A.L.(2019).Enzinger&Weiss'sSoftTissueTumors-SeventhEdition.Philadelphia,PA.Elsevier.2)G
7. Rhabdomyosarcoma (RMS) (for Parents)
[SkiptoContent]SharetoFacebookSharetoTwitterSharetoPinterestShareviaEmailKidsHealth/forParents/Rhabdomyosarcoma(RMS)Rhabdomyosarcoma(RMS)Reviewedby:ScottM.Bradfield,MD,MBALargertextsizeLargetextsizeRegulartextsizePrintenespañolRabdomiosarcomaWhatIsRhabdomyosarcoma(RMS)?Rhabdomyosarcoma(RMSor"rhabdo")isacanceroustumorthatdevelopsinthebody'ssofttissues,usuallythemuscles.Itcanaffectthehead,neck,bladder,vagina,arms,legs,trunk,orjustaboutanybodypart.Cellsfromrhabdomyosarcomasareoftenfastgrowingandcanspread(metastasize)tootherpartsofthebody.Rhabdomyosarcoma(rab-doe-myo-sar-KO-muh)isthemostcommontypeofsoft-tissuecancerinchildren.Kidscandevelopitatanyage,butmostcasesareinkidsbetween2and6yearsoldand15and19yearsold.Boystendtobeaffectedmoreoftenthangirls.TreatingRMSusuallyincludeschemotherapy,surgery,andradiation.Withearlydetectionandtimelytreatment,mostkidsmakeafullrecovery.TypesofTumorsThetwomaintypesofRMSinkidsare:EmbryonalRMS:Thistumorusuallydevelopsintheheadandneckarea,genitals,orurinarytract.Ittypicallyaffectskidsyoungerthan6.Althoughit'sanaggressive(fast-growing)typeoftumor,mostcasesofembryonalRMSrespondwelltotreatment.AlveolarRMS:Thistype,whichismostlikelytohappenduringtheteenyears,mostoftenaffectsthearmsorlegs,chest,orabdomen.It,too,isfast-growingbutoftenmoredifficulttotreat.MostkidswithalveolarRMSneedintensivetreatment.WhatCausesRhabdomyosarcoma(RMS)?ThecauseofRMSisn'tclear,butdoctorsknowthatcertainmedicalconditionscanmakesomechildrenmorelikelytodevelopit.Theseincludegeneticconditionslike:Li-Fraumenisyndrome,araregeneticdisorderthatmakesapersonlikelytodevelopcanceratsomepointinhisorherlifeNeurofibromatosis,aconditionthatcausestumorstogrowonnervetissueBeckwith-Wiedemannsyndrome,acongenital(presentatbirth)disorderthatcancausetoomuchgrowthinthebody,includingtheinternalorgansCostellosyndromeandNoonansyndrome,bothofwhichcancausedeformities,developmentaldelays,andotherproblemsWhatAretheSignsandSymptomsof Rhabdomyosarcoma(RMS)?SymptomsofRMSdependonthesizeandlocationofthetum
8. Pathologic Classification of Rhabdomyosarcomas and ...
Histology and prognosis in rhabdomyosarcoma: a report of the Intergroup Rhabdomyosarcoma Study [Abstract]. Proc SIOP 1981; 13: 113. Google ...SkiptomaincontentThankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtainthebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodeinInternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstylesandJavaScript.AdvertisementnaturemodernpathologyreviewarticlesarticlePathologicClassificationofRhabdomyosarcomasandCorrelationswithMolecularStudiesDownloadPDFAbstractRhabdomyosarcoma,themostcommonsoft-tissuemalignancyofchildhoodandadolescence,comprisesagroupofdifferingpathobiologicentitieslinkedbytheircommonpropensityforformationofneoplasticskeletalmuscle,afeaturethatresultsfrombiologicalforcesrelatedtoaberranttranscriptionsignalsandtheresultantproductionofmyogenicproteins.Atamolecularlevel,however,rhabdomyosarcomasformaheterogeneousgroupthatcanbesubdividedintodistinctclinicopathologicentitiesbasedonmorphologicappearanceandgeneticmakeup.Thesedifferingmorphologicfeatureswererecognizedinthemid-1900sbyHornandEnterlinewiththeirdivisionofrhabdomyosarcomasintoembryonal,alveolar,botryoid,andpleomorphicsubtypes.Morerecenthistologicandbiologicstudieshaveresultedindescriptionofadditionalentities,suchasspindlecellandanaplasticrhabdomyosarcoma,andrefinementsinrecognitionoftheoriginalentities,suchassolid-alveolarrhabdomyosarcoma.Familiaritywithnewerclassificationsandtheirrelationshiptomolecularaberrationsiskeytostratifyingpatientsoncurrenttherapeuticprotocolsandproposedinnovativegenetictherapies.DownloadPDFINTRODUCTIONAlthoughrelativelyrareinadults,rhabdomyosarcomasarethemostcommonsoft-tissuemalignancyinchildrenandadolescents,inwhomtheycompriseapproximately60%ofsarcomasreportedperannum(1).Inmanyways,thehistologyoftheseneoplasmsisanalogoustomyogenesisinthedevelopingembryo,yieldingcluestothebiologyoftheselesions.Forthisreason,itismorecorrecttodefinerhabdomyosarcoma
9. Childhood Rhabdomyosarcoma Treatment (PDQ®)–Patient Version ...
SkiptomaincontentEspañol1-800-4-CANCERLiveChatPublicationsDictionaryHomeCancerTypesSoftTissueSarcomaPatientSoftTissueSarcomaPatientAdultSoftTissueSarcomaTreatmentGIStromalTumorsTreatmentChildhoodGastrointestinalStromalTumorsTreatmentKaposiSarcomaTreatmentChildhoodRhabdomyosarcomaTreatmentChildhoodSoftTissueSarcomaTreatmentChildhoodVascularTumorsTreatmentHealthProfessionalAdultSoftTissueSarcomaTreatmentGIStromalTumorsTreatmentChildhoodGastrointestinalStromalTumorsTreatmentKaposiSarcomaTreatmentChildhoodRhabdomyosarcomaTreatmentChildhoodSoftTissueSarcomaTreatmentChildhoodVascularTumorsTreatmentResearchChildhoodRhabdomyosarcomaTreatment(PDQ®)–PatientVersionOnThisPageGeneralInformationAboutChildhoodRhabdomyosarcomaStagesofChildhoodRhabdomyosarcomaTreatmentOptionOverviewTreatmentofChildhoodRhabdomyosarcomaTreatmentofProgressiveorRecurrentChildhoodRhabdomyosarcomaToLearnMoreAboutChildhoodRhabdomyosarcomaAboutThisPDQSummaryGeneralInformationAboutChildhoodRhabdomyosarcomaGotoHealthProfessionalVersionKeyPointsChildhoodrhabdomyosarcomaisadiseaseinwhichmalignant(cancer)cellsforminmuscletissue.Certaingeneticconditionsincreasetheriskofchildhoodrhabdomyosarcoma.Asignofchildhoodrhabdomyosarcomaisalumporswellingthatkeepsgettingbigger.Diagnostictestsandabiopsyareusedtodiagnosechildhoodrhabdomyosarcoma.Certainfactorsaffectprognosis(chanceofrecovery)andtreatmentoptions.Childhoodrhabdomyosarcomaisadiseaseinwhichmalignant(cancer)cellsforminmuscletissue.Rhabdomyosarcomaisatypeofsarcoma.Sarcomaiscancerofsofttissue(suchasmuscle),connectivetissue(suchastendonorcartilage),orbone.Rhabdomyosarcomausuallybeginsinmusclesthatareattachedtobonesandthathelpthebodymove,butitmaybegininmanyplacesinthebody.Rhabdomyosarcomaisthemostcommontypeofsofttissuesarcomainchildren.Therearefourmaintypesofrhabdomyosarcoma:Embryonal:Thistypeoccursmostoftenintheheadandneckareaorinthegenitalorurinaryorgans,butcanoccuranywhereinthebody.Itisthemostcommontypeofrhabdomyosarcoma.Alveolar:Thistypeoccursmostofteninthearmsorle
10. Rhabdomyosarcoma
SkiptoContentSearchMenuYouarehereHome>TypesofCancer>Rhabdomyosarcoma-Childhood>Rhabdomyosarcoma-Childhood:DiagnosisRequestPermissionsRhabdomyosarcoma-Childhood:DiagnosisApprovedbytheCancer.NetEditorialBoard,10/2018ONTHISPAGE:Youwillfindalistofcommontests,procedures,andscansthatdoctorsusetofindthecauseofthemedicalproblem.Usethemenutoseeotherpages.Doctorsusemanyteststofind,ordiagnose,cancer.Theyalsodoteststolearnifcancerhasspreadtoanotherpartofthebodyfromwhereitstarted.Ifthishappens,itiscalledmetastasis.Forexample,imagingtests(X-ray,CT,MRI),whichshowpicturesoftheinsideofthebody,canshowifthecancerhasspread.Doctorsmayalsodoteststolearnwhichtreatmentsmightworkbest.Thislistdescribesoptionsfordiagnosingthistypeofcancer.Notalltestslistedbelowwillbeusedforeveryperson.Yourchild’sdoctormayconsiderthesefactorswhenchoosingadiagnostictest:ThetypeofcancersuspectedYourchild’ssignsandsymptomsYourchild’sageandgeneralhealthTheresultsofearliermedicaltestsInadditiontoaphysicalexamination,thefollowingtestsmaybeusedtodiagnoserhabdomyosarcoma:Biopsy.Abiopsyistheremovalofasmallamountoftissueforexaminationunderamicroscope.Othertestscansuggestthatcancerispresent,butonlyabiopsycanmakeadefinitediagnosis.Thetypeofbiopsyperformedwilldependonthelocationofthecancer.Ifthetumorisnearthesurfaceofthebody,thechildwillbegivenalocalanesthetictonumbtheareaduringtheprocedure.Ifitisdeeperinsidethebody,ageneralanesthetic(medicationtoblocktheawarenessofpain)willbeused.Apathologistthenanalyzesthesample(s).Apathologistisadoctorwhospecializesininterpretinglaboratorytestsandevaluatingcells,tissues,andorganstodiagnosedisease.Immunocytochemistrytests.Thesearespecialstainsdoneonthecellstakenduringthebiopsytohelpthedoctormakeanaccuratediagnosisofrhabdomyosarcoma.Stainsthatshowmusclecelldevelopment,includingactin,desmin,MyoD-1,andMyogenin,aremosthelpful.Genetictestsoftumortissue.Chromosomesarestructuresthatcontainthegenesinacell.Changesincertainchromosomesinthetumorcells,calledchromosomaltranslocations,canhelpdoctorsid
11. Pleomorphic rhabdomyosarcoma
... rhabdomyosarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissuepleomorphicrhabdo.html. Accessed ...AuthorsBlogBoardReviewCommentContactUsNewslettersStatisticsTestimonialsSeeElsevier'snewvideoabouttheirClinicReviewArticlesonourhomepageorclickhere.JobsFellowshipsConferences/WebinarsBooksCMECasesAdvertiseGrantsMedicalNewsLibrariesRocheCompanionDiagnosticLibraryRocheNTRKIHCDiagnosticLibraryCOVID-19LibraryPandemicreliefmusicawardHome>Softtissue>PleomorphicrhabdomyosarcomaSofttissueSkeletalmuscleRhabdomyosarcomaPleomorphicrhabdomyosarcomaAuthor: ErdenerÖzer,M.D.,Ph.D.EditorialBoardMember: MichaelR.Clay,M.D.Editor-in-Chief: DebraL.Zynger,M.D.TopicCompleted:1February2018Minorchanges:2December2020Copyright:2002-2021,PathologyOutlines.com,Inc.PubMedSearch:Pleomorphicrhabdomyosarcoma[TI]Pageviewsin2020:6,928Pageviewsin2021todate:2,868TableofContentsDefinition/general|Essentialfeatures|Epidemiology|Clinicalfeatures|Radiologyimages|Casereports|Treatment|Grossdescription|Grossimages|Microscopic(histologic)description|Microscopic(histologic)images|Positivestains|Negativestains|Electronmicroscopydescription|Electronmicroscopyimages|Molecular/cytogeneticsdescription|Differentialdiagnosis|Additionalreferences|Boardreviewstylequestion#1|Boardreviewstyleanswer#1Citethispage:Özer,E.Pleomorphicrhabdomyosarcoma.PathologyOutlines.comwebsite.https://www.pathologyoutlines.com/topic/softtissuepleomorphicrhabdo.html.AccessedApril13th,2021.Definition/generalHighgradesarcomacomposedofundifferentiatedcells(Fletcher:WHOClassificationofTumoursofSoftTissueandBone,4thEdition,2013)Exceedinglyrarecategoryofrhabdomyosarcoma(RMS)inadultsNotwellcharacterizedinthepediatricpopulation;manyofthesecasescanbeconsideredRMSwithdiffuseanaplasiaEssentialfeaturesHighgradesarcomacomposedofatypicalcellsthatdisplayskeletalmuscledifferentiationNoembryonaloralveolarcomponentofrhabdomyosarcomaEpidemiologyUsuallyolderthan5070%maleClinicalfeaturesRapidlygrowing,painfulmass,mostcommonl
12. Embryonal rhabdomyosarcoma
AuthorsBlogBoardReviewCommentContactUsNewslettersStatisticsTestimonialsSeeElsevier'snewvideoabouttheirClinicReviewArticlesonourhomepageorclickhere.JobsFellowshipsConferences/WebinarsBooksCMECasesAdvertiseGrantsMedicalNewsLibrariesRocheCompanionDiagnosticLibraryRocheNTRKIHCDiagnosticLibraryCOVID-19LibraryPandemicreliefmusicawardHome>Softtissue>EmbryonalrhabdomyosarcomaSofttissueSkeletalmuscleRhabdomyosarcomaEmbryonalrhabdomyosarcomaAuthor: MichaelR.Clay,M.D.Editor-in-Chief: DebraL.Zynger,M.D.TopicCompleted:1May2018Minorchanges:21January2021Copyright:2002-2021,PathologyOutlines.com,Inc.PubMedSearch:Embryonalrhabdomyosarcoma[TI]pathologyfreefulltext[sb]Relatedtopics:Rhabdomyosarcoma,NOS,spindlecellPageviewsin2020:24,673Pageviewsin2021todate:9,583TableofContentsDefinition/general|Essentialfeatures|Terminology|ICDcoding|Epidemiology|Sites|Pathophysiology|Etiology|Prognosticfactors|Casereports|Treatment|Grossdescription|Grossimages|Pitfallsandtips|Microscopic(histologic)description|Microscopic(histologic)images|Cytologydescription|Cytologyimages|Positivestains|Electronmicroscopydescription|Molecular/cytogeneticsdescription|Differentialdiagnosis|Additionalreferences|Boardreviewstylequestion#1|Boardreviewstyleanswer#1|Boardreviewstylequestion#2|Boardreviewstyleanswer#2Citethispage:ClayM.Embryonalrhabdomyosarcoma.PathologyOutlines.comwebsite.https://www.pathologyoutlines.com/topic/softtissueembryonalrhabdo.html.AccessedApril13th,2021.Definition/generalSubtypeoftherhabdomyosarcoma(RMS)softtissuecancerfamilywhoselineagederivesfromtheundifferentiatedmesodermEmbryonalrhabdomyosarcoma(ERMS)isthemostcommonRMSsubtypeSeveraldistinctandprognosticpatternsofgrowthhavebeennoted,includingthebotryoidandanaplasticvariantsEssentialfeaturesMostcommonsubtypeofrhabdomyosarcomainthepediatricandadolescentsettingAnaplasiaisassociatedwithTP53mutations,p53proteinoverexpressionandworseoverallprognosis(Cancer2014;120:1068)Displaysawidespectrumofmorphologicfeatures,includingcaseswithspindledmorphology