AuthorsBlogBoardReviewCommentContactUsNewslettersStatisticsTestimonialsSeeElsevier'snewvideoabouttheirClinicReviewArticlesonourhomepageorclickhere.JobsFellowshipsConferences/WebinarsBooksCMECasesAdvertiseGrantsMedicalNewsLibrariesRocheCompanionDiagnosticLibraryRocheNTRKIHCDiagnosticLibraryCOVID-19LibraryPandemicreliefmusicawardHome>Softtissue>EmbryonalrhabdomyosarcomaSofttissueSkeletalmuscleRhabdomyosarcomaEmbryonalrhabdomyosarcomaAuthor: MichaelR.Clay,M.D.Editor-in-Chief: DebraL.Zynger,M.D.TopicCompleted:1May2018Minorchanges:21January2021Copyright:2002-2021,PathologyOutlines.com,Inc.PubMedSearch:Embryonalrhabdomyosarcoma[TI]pathologyfreefulltext[sb]Relatedtopics:Rhabdomyosarcoma,NOS,spindlecellPageviewsin2020:24,673Pageviewsin2021todate:9,583TableofContentsDefinition/general|Essentialfeatures|Terminology|ICDcoding|Epidemiology|Sites|Pathophysiology|Etiology|Prognosticfactors|Casereports|Treatment|Grossdescription|Grossimages|Pitfallsandtips|Microscopic(histologic)description|Microscopic(histologic)images|Cytologydescription|Cytologyimages|Positivestains|Electronmicroscopydescription|Molecular/cytogeneticsdescription|Differentialdiagnosis|Additionalreferences|Boardreviewstylequestion#1|Boardreviewstyleanswer#1|Boardreviewstylequestion#2|Boardreviewstyleanswer#2Citethispage:ClayM.Embryonalrhabdomyosarcoma.PathologyOutlines.comwebsite.https://www.pathologyoutlines.com/topic/softtissueembryonalrhabdo.html.AccessedApril13th,2021.Definition/generalSubtypeoftherhabdomyosarcoma(RMS)softtissuecancerfamilywhoselineagederivesfromtheundifferentiatedmesodermEmbryonalrhabdomyosarcoma(ERMS)isthemostcommonRMSsubtypeSeveraldistinctandprognosticpatternsofgrowthhavebeennoted,includingthebotryoidandanaplasticvariantsEssentialfeaturesMostcommonsubtypeofrhabdomyosarcomainthepediatricandadolescentsettingAnaplasiaisassociatedwithTP53mutations,p53proteinoverexpressionandworseoverallprognosis(Cancer2014;120:1068)Displaysawidespectrumofmorphologicfeatures,includingcaseswithspindledmorphology