... rhabdomyosarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissuepleomorphicrhabdo.html. Accessed ...AuthorsBlogBoardReviewCommentContactUsNewslettersStatisticsTestimonialsSeeElsevier'snewvideoabouttheirClinicReviewArticlesonourhomepageorclickhere.JobsFellowshipsConferences/WebinarsBooksCMECasesAdvertiseGrantsMedicalNewsLibrariesRocheCompanionDiagnosticLibraryRocheNTRKIHCDiagnosticLibraryCOVID-19LibraryPandemicreliefmusicawardHome>Softtissue>PleomorphicrhabdomyosarcomaSofttissueSkeletalmuscleRhabdomyosarcomaPleomorphicrhabdomyosarcomaAuthor: ErdenerÖzer,M.D.,Ph.D.EditorialBoardMember: MichaelR.Clay,M.D.Editor-in-Chief: DebraL.Zynger,M.D.TopicCompleted:1February2018Minorchanges:2December2020Copyright:2002-2021,PathologyOutlines.com,Inc.PubMedSearch:Pleomorphicrhabdomyosarcoma[TI]Pageviewsin2020:6,928Pageviewsin2021todate:2,868TableofContentsDefinition/general|Essentialfeatures|Epidemiology|Clinicalfeatures|Radiologyimages|Casereports|Treatment|Grossdescription|Grossimages|Microscopic(histologic)description|Microscopic(histologic)images|Positivestains|Negativestains|Electronmicroscopydescription|Electronmicroscopyimages|Molecular/cytogeneticsdescription|Differentialdiagnosis|Additionalreferences|Boardreviewstylequestion#1|Boardreviewstyleanswer#1Citethispage:Özer,E.Pleomorphicrhabdomyosarcoma.PathologyOutlines.comwebsite.https://www.pathologyoutlines.com/topic/softtissuepleomorphicrhabdo.html.AccessedApril13th,2021.Definition/generalHighgradesarcomacomposedofundifferentiatedcells(Fletcher:WHOClassificationofTumoursofSoftTissueandBone,4thEdition,2013)Exceedinglyrarecategoryofrhabdomyosarcoma(RMS)inadultsNotwellcharacterizedinthepediatricpopulation;manyofthesecasescanbeconsideredRMSwithdiffuseanaplasiaEssentialfeaturesHighgradesarcomacomposedofatypicalcellsthatdisplayskeletalmuscledifferentiationNoembryonaloralveolarcomponentofrhabdomyosarcomaEpidemiologyUsuallyolderthan5070%maleClinicalfeaturesRapidlygrowing,painfulmass,mostcommonl