Introduction. Lassa virus, which is a member of the Arenaviridae virus family, causes acute viral hemorrhagic fever. It was first reported in 1969 in the town of Lassa ...LassaCapsidHomeViralAntigensLassaLassaCapsidChooseProductCategoryCytokinesGrowthFactorsChemokinesCDAntigensNeurotrophinsHormonesEnzymesViralAntigensRecombinantProteinsNaturalProteinsMonoclonalAntibodiesPolyclonalAntibodiesNameDescriptionCat#PricingsQuantityLassaCapsidLassaCapsidRecombinantLSV-001100µg($150)500µg($600)1mg($1200)ShippedwithIcePacksAddtoCartBacktoTopCataloguenumberLSV-001IntroductionLassavirus,whichisamemberoftheArenaviridaevirusfamily,causesacuteviralhemorrhagicfever.Itwasfirstreportedin1969inthetownofLassa,inBornoState,Nigeria.NatalmultimammatemouseistheprimaryreservoirofLassavirus,foundinsub-SaharanAfrica.Thevirusistransmittedbycontactwiththefecesorurineofanimals,contributingtoitshighrateofincidence.LassafeveroccursgenerallyinWestAfrica.Lassafeverresultsin300,000to500,000casesannuallyandcausesabout5,000deathseachyear.OutbreaksofthisdiseasehavebeenobservedinNigeria,Liberia,SierraLeone,Guinea,andtheCentralAfricanRepublic.Proteinstructure:Lassavirusgenomeiscomprisedoftwosingle-strandedRNAmoleculesdefinedassmall(S)andlarge(L).TwogenesontheSsegmentencodethenucleoprotein(NP)andtwoenvelopeglycoproteins(GP1andGP2);while,theLsegmentencodestheviralpolymerase(Lprotein)andRINGfingerZmatrixprotein.GP1subunitservesaputativeroleinreceptorbinding,whilethestructureofGP2subunitisconsistentwithviraltransmembranefusionproteins.NPisavirionproteinwhichbindsandprotectstheviralRNA.DescriptionTheE.ColiderivedRecombinantLassaNucleoprotein(LASVstrainAV,GenBankaccessionnumberAAG41803)containing420aminoacidsofLassavirusnucleoprotein. TheLassaCapsidproteinisfusedtoa6xHistagatC-terminusandpurifiedbyproprietarychromatographictechnique.SourceEscherichiaColi.PhysicalAppearanceSterileFilteredsolution.FormulationLassaCapsidproteinsolutioncontains 25mMTrisBase/10mMK2CO3.StabilityLassaCapsidproteinalthoughstableat4°Cfo