Structural Characteristics of Nairoviruses (Genus Nairovirus, Bunyaviridae) Free. John P. M. Clerx, Jordi Casals and David H. L. Bishop ...1887TogglenavigationToolsTogglenavigationShareJournalofGeneralVirologyVolume55,Issue1ResearchArticleFreeStructuralCharacteristicsofNairoviruses(GenusNairovirus,Bunyaviridae)JohnP.M.Clerx,JordiCasals andDavidH.L.BishopFirstPublished:01July1981https://doi.org/10.1099/0022-1317-55-1-165infoInfoArticleinformationCitedBy(52)MetricslistSectionsAccessfulltextArticlePDFbuildToolsToolsAddtomyfavouritesCreatePublicationAlertCreateCitationAlertCreateCorrectionAlertExportcitationBibTEXEndnoteZoteroRefWorksMendeleyRecommendtolibrary/recommendto/form?webId=%2Fcontent%2Fjournal%2Fjgv&title=Journal+of+General+Virology&issn=0022-1317&eissn=1465-2099JournalofGeneralVirology—RecommendthistitletoyourlibraryReprints&PermissionsshareShareShareAbstractSummaryVirusesfromsixantigenicgroupsofarthropod-borneviruses[Crimean-Congohaemorrhagicfever(CCHF),Nairobisheepdisease(NSD),Qalyub(QYB),Sakhalin(SAK),DeraGhaziKhan(DGK)andHughes(HUG)serogroups],somepreviouslycategorizedasbunyavirus-likevirusesandotherspreviouslyungrouped,haverecentlybeenassembledbyserologicalanalysesintoanewgenusofviruses(Nairovirusgenus)intheBunyaviridae.MolecularstudiesofthevirionRNAandviralpolypeptideshavebeenundertakenwithrepresentativemembersofthedifferentserogroups[Hazara(HAZ)andCongo(CON)viruses,CCHFgroup;Dugbe(DUG)virus,NSDgroup;QYB,OmoandBandia(BDA)viruses,QYBgroup;Avalon(AVA)virus,SAKgroup;DGKandAbuMina(AM)viruses,DGKgroup;andHUGvirus,HUGgroup].InagreementwitharecentstudyofQYBvirusandinpartagreementwithanearlierreportonDUGvirus,theresultsofthesemolecularanalysesindicatethatnairoviruseshave:(i)threevirionRNAspecies(large,L,medium,M,andsmall,S)withapparentmol.wt.of4.1×106to4.9×106,1.5×106to1.9×106and0.6×106to0.7×106respectively;(ii)a48×103to54×103mol.wt.nucleocapsid(N)polypeptide;and(iii)twoexternalglycopolypeptides,72×103to84×103mol.wt.(G1)and30×103to40×103mol.wt.(G2).Cross-immune