Replication[edit]. Nairovirus life cycle. Nairoviruses attach to the host receptor by their Gn-Gc glycoprotein dimer.OrthonairovirusFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchGenusofvirusesOrthonairovirusCrimean-CongohemorrhagicfeverorthonairovirusvirionandgenomeVirusclassification(unranked):VirusRealm:RiboviriaKingdom:OrthornaviraePhylum:NegarnaviricotaClass:EllioviricetesOrder:BunyaviralesFamily:NairoviridaeGenus:OrthonairovirusTypespeciesDugbeorthonairovirusOrthonairovirusisagenusinthefamilyNairoviridaeoftheorderBunyaviralesthatincludeviruseswithcircular,negative-sensesinglestrandedRNA.[2]ItgotitsnamefromtheNairobisheepdiseasethataffectsthegastrointestinaltractsofsheepandgoats.[2]Thevastmajority,andperhapsallvirusesinthisgenusaretick-bornevirusesthatcanhavehumanorothervertebratehosts.[3]Contents1Structure2Genome3Replication4Transmissionanddistribution5Clinicalimportance6Evolution7Taxonomy8Serogroups9References10ExternallinksStructure[edit]Thevirionsforvirusesinthisgenushaveasphericalshape.[4]Theyrangeinsizefromabout80–120 nmindiameter,with50%oftheirweightattributedtoproteinsand20–30%oftheirweightattributedtolipids.[2]Theribonucleocapsidisfilamentous,havingalengthofabout200-300 nmandawidthofabout2–2.5 nm.[2]Thesenucleocapsidsaresurroundedbyasingleenvelopethathasprojectionsmadeofglycoproteinsprotrudingfromitssurface.Theseprojectionsevenlycoverthesurfaceofthevirion,andareabout5–10 nmlong.[2]Theyaidinattachmenttothehostreceptorinreplication.Genome[edit]Crimean-Congohemorrhagicfevervirus(CCHFV)genomeNairovirusgenomesarenegativesense,single-strandedRNA.Thecompletegenomeisabout17,100–22,800nucleotideslong,andisdividedintothreesegments:large,medium,andsmall.[3]Thelargesegmentisabout11000–14400nucleotideslong(11–14.4kb),anditencodestheviralpolymerase.[2][4]Themediumsegmentisabout4,400–6,300nucleotideslong(4.4–6.3kb),anditencodesforglycoproteinsG¬nandGc.[2][4]Thesmallsegmentisabout1,700–2,100nucleotideslong(1.7–2.1kb),anditencodesthenucleocapsidprotein.[3