Other articles where Nairovirus is discussed: bunyavirus: Phlebovirus, Nairovirus, Tospovirus, and Hantavirus. Most of these viruses are transmitted by ...NairovirusArticleNairovirusvirusgenusShareShareSharetosocialmediaFacebookTwitterURLhttps://www.britannica.com/science/NairovirusLearnaboutthistopicinthesearticles:bunyavirusesInbunyavirusPhlebovirus,Nairovirus,Tospovirus,andHantavirus.Mostofthesevirusesaretransmittedbyarthropods(e.g.,ticks,mosquitoes,andsandflies)andcauseserioushumandisease,includingcertaintypesofviralhemorrhagicfever.ReadMorecloseRinginthenewyearwithaBritannicaMembership

The genus Nairovirus (family Bunyaviridae) contains seven serogroups consisting of 34 predominantly tick-borne viruses, including several associated with ...Clipboard,SearchHistory,andseveralotheradvancedfeaturesaretemporarilyunavailable.SkiptomainpagecontentCOVID-19isanemerging,rapidlyevolvingsituation.Publichealthinformation(CDC)Researchinformation(NIH)SARS-CoV-2data(NCBI)Preventionandtreatmentinformation(HHS) AccesskeysNCBIHomepageMyNCBIHomepageMainContentMainNavigationSearch:SearchAdvancedClipboardUserGuideSaveEmailSendtoClipboardMyBibliographyCollectionsCitationmanagerDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSavecitationtofileFormat:Summary(text)PubMedPMIDAbstract(text)CSVCreatefileCancelEmailcitationSubject:1selecteditem:14972529-PubMedTo:Format:SummarySummary(text)AbstractAbstract(text)MeSHandotherdataSendemailCancelAddtoCollectionsCreateanewcollectionAddtoanexistingcollectionNameyourcollection:Namemustbelessthan100charactersChooseacollection:UnabletoloadyourcollectionduetoanerrorPleasetryagainAddCancelAddtoMyBibliographyMyBibliographyUnabletoloadyourdelegatesduetoanerrorPleasetryagainAddCancelYoursavedsearchNameofsavedsearch:Searchterms:TestsearchtermsWouldyoulikeemailupdatesofnewsearchresults?SavedSearchAlertRadioButtonsYesNoEmail:(change)Frequency:MonthlyWeeklyDailyWhichday?ThefirstSundayThefirstMondayThefirstTuesdayThefirstWednesdayThefirstThursdayThefirstFridayThefirstSaturdayThefirstdayThefirstweekdayWhichday?SundayMondayTuesdayWednesdayThursdayFridaySaturdayReportformat:SummarySummary(text)AbstractAbstract(text)PubMedSendatmost:1item5items10items20items50items100items200itemsSendevenwhentherearen'tanynewresultsOptionaltextinemail:SaveCancelCreateafileforexternalcitationmanagementsoftwareCreatefileCancelYourRSSFeedNameofRSSFeed:Numberofitemsdisplayed:510152050100CreateRSSCancelRSSLinkCopyFulltextlinksElsevierScienceFulltextlinksActionsCiteFavoritesDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSharePermalinkCopyPagenavigationTitle&author

Replication[edit]. Nairovirus life cycle. Nairoviruses attach to the host receptor by their Gn-Gc glycoprotein dimer.OrthonairovirusFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchGenusofvirusesOrthonairovirusCrimean-CongohemorrhagicfeverorthonairovirusvirionandgenomeVirusclassification(unranked):VirusRealm:RiboviriaKingdom:OrthornaviraePhylum:NegarnaviricotaClass:EllioviricetesOrder:BunyaviralesFamily:NairoviridaeGenus:OrthonairovirusTypespeciesDugbeorthonairovirusOrthonairovirusisagenusinthefamilyNairoviridaeoftheorderBunyaviralesthatincludeviruseswithcircular,negative-sensesinglestrandedRNA.[2]ItgotitsnamefromtheNairobisheepdiseasethataffectsthegastrointestinaltractsofsheepandgoats.[2]Thevastmajority,andperhapsallvirusesinthisgenusaretick-bornevirusesthatcanhavehumanorothervertebratehosts.[3]Contents1Structure2Genome3Replication4Transmissionanddistribution5Clinicalimportance6Evolution7Taxonomy8Serogroups9References10ExternallinksStructure[edit]Thevirionsforvirusesinthisgenushaveasphericalshape.[4]Theyrangeinsizefromabout80–120 nmindiameter,with50%oftheirweightattributedtoproteinsand20–30%oftheirweightattributedtolipids.[2]Theribonucleocapsidisfilamentous,havingalengthofabout200-300 nmandawidthofabout2–2.5 nm.[2]Thesenucleocapsidsaresurroundedbyasingleenvelopethathasprojectionsmadeofglycoproteinsprotrudingfromitssurface.Theseprojectionsevenlycoverthesurfaceofthevirion,andareabout5–10 nmlong.[2]Theyaidinattachmenttothehostreceptorinreplication.Genome[edit]Crimean-Congohemorrhagicfevervirus(CCHFV)genomeNairovirusgenomesarenegativesense,single-strandedRNA.Thecompletegenomeisabout17,100–22,800nucleotideslong,andisdividedintothreesegments:large,medium,andsmall.[3]Thelargesegmentisabout11000–14400nucleotideslong(11–14.4kb),anditencodestheviralpolymerase.[2][4]Themediumsegmentisabout4,400–6,300nucleotideslong(4.4–6.3kb),anditencodesforglycoproteinsG¬nandGc.[2][4]Thesmallsegmentisabout1,700–2,100nucleotideslong(1.7–2.1kb),anditencodesthenucleocapsidprotein.[3

The genus Nairovirus includes seven species that are accepted by the International Committee on Taxonomy of Viruses (ICTV) [1]. Most of these ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListVirusesv.8(6);2016JunPMC4926184Viruses.2016Jun;8(6):164.Publishedonline2016Jun10.doi: 10.3390/v8060164PMCID:PMC4926184PMID:27294949GenomicCharacterizationoftheGenusNairovirus(FamilyBunyaviridae)JensH.Kuhn,1MichaelR.Wiley,2SergioE.Rodriguez,3YīmíngBào,4KarlaPrieto,2AmeliaP.A.TravassosdaRosa,3HildaGuzman,3NazirSavji,5JasonT.Ladner,2RobertB.Tesh,3JiroWada,1PeterB.Jahrling,1DennisA.Bente,3andGustavoPalacios2,*JensH.Kuhn1IntegratedResearchFacilityatFortDetrick,DivisionofClinicalResearch,NationalInstituteofAllergyandInfectiousDiseases,NationalInstitutesofHealth,Frederick,MD21702,USA;vog.hin.liam@snejnhuk(J.H.K.);vog.hin.liam@jadaw(J.W.);vog.hin.diain@pgnilrhaj(P.B.J.)FindarticlesbyJensH.KuhnMichaelR.Wiley2CenterforGenomeSciences,UnitedStatesArmyMedicalResearchInstituteofInfectiousDiseases,FortDetrick,Frederick,MD21702,USA;[email protected](M.R.W.);[email protected](K.P.);[email protected](J.T.L.)FindarticlesbyMichaelR.WileySergioE.Rodriguez3GalvestonNationalLaboratory,InstituteforHumanInfectionandImmunity,DepartmentofMicrobiology&Immunology,UniversityofTexasMedicalBranch,Galveston,TX77555,USA;ude.bmtu@irdorees(S.E.R.);ude.bmtu@savartpa(A.P.A.T.d.R.);ude.bmtu@namzugh(H.G.);ude.bmtu@hsetr(R.B.T.);ude.bmtu@etnebad(D.A.B.)FindarticlesbySergioE.RodriguezYīmíngBào4InformationEngineeringBranch,NationalCenterforBiotechnologyInformation,NationalLibraryofMedicine,NationalInstitutesofHealth,Bethesda,MD20892,USA;vog.hin.mln.ibcn@oab(Y.B.)FindarticlesbyYīmíngBàoKarlaPrieto2CenterforGenomeSciences,UnitedStatesArmyMedicalResearchInstituteofInfectiousDiseases,FortDetrick,Frederick,MD21702,USA;[email protected](M.R.W.);[email protected](K.P.);[email protected](J.T.L.)Findarticlesby

The Nairovirus genus comprises a number of pathogens that cause infectious diseases in humans and livestock. Nairoviruses are transmitted by ticks, which ...SkiptomaincontentStructureandAssemblyStructuralandFunctionalDiversityofNairovirus-EncodedNucleoproteinsWenmingWang,XiangLiu,XuWang,HuiDong,ChaoMa,JingminWang,BaochengLiu,YonghongMao,YingWang,TingLi,ChengYang,YuGuoS.López,EditorWenmingWangaStateKeyLaboratoryofMedicinalChemicalBiologyandCollegeofPharmacy,NankaiUniversity,Tianjin,People'sRepublicofChinacInstituteofMolecularScience,ChemicalBiologyandMolecularEngineeringLaboratoryofEducationMinistry,ShanxiUniversity,Taiyuan,Shanxi,ChinaFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteXiangLiubTianjinInternationalJointAcademyofBiotechnologyandMedicine,Tianjin,People'sRepublicofChinaFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteXuWangaStateKeyLaboratoryofMedicinalChemicalBiologyandCollegeofPharmacy,NankaiUniversity,Tianjin,People'sRepublicofChinabTianjinInternationalJointAcademyofBiotechnologyandMedicine,Tianjin,People'sRepublicofChinaFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteHuiDongdKeyLaboratoryofTianjinRadiationandMolecularNuclearMedicine,InstituteofRadiationMedicine,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Tianjin,ChinaFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteChaoMaaStateKeyLaboratoryofMedicinalChemicalBiologyandCollegeofPharmacy,NankaiUniversity,Tianjin,People'sRepublicofChinabTianjinInternationalJointAcademyofBiotechnologyandMedicine,Tianjin,People'sRepublicofChinaFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteJingminWangaStateKeyLaboratoryofMedicinalChemicalBiologyandCollegeofPharmacy,NankaiUniversity,Tianjin,People'sRepublicofChinabTianjinInternationalJointAcademyofBiotechnologyandMedicine,Tianjin,People'sRepublicofChinaFindthisauthoronGoogleScholarFindthisauthoronPubMed

Genus: Nairovirus. Viral Example: Crimean-Congo Hemorrhagic Fever. Their general characteristics include: Tick-born Transmission; Ability to cause ...Genus:NairovirusViralExample:Crimean-CongoHemorrhagicFeverTheirgeneralcharacteristicsinclude:Tick-bornTransmissionAbilitytocauseHemorrhagicFeverSyndromeBelowisapictureofaticktakingabloodmeal,potentiallypassingonCCHF:

ArticleAuthorsMetricsCommentsMediaCoverageReaderComments(0)FiguresFiguresAbstractPost-translationalmodificationofhostandviralproteinsbyubiquitin(Ub)andUb-likeproteins,suchasinterferonstimulatedgeneproduct15(ISG15),playsakeyroleinresponsetoinfection.Viruseshavebeenincreasinglyidentifiedthatcontainproteasespossessingdeubiquitinase(DUB)and/ordeISGylasefunctions.ThisincludesvirusesintheNairoviridaefamilythatencodeaviralhomologueoftheovariantumorprotease(vOTU).vOTUactivitywasrecentlydemonstratedtobecriticalforreplicationoftheoften-fatalCrimean-Congohemorrhagicfevervirus,withDUBactivitysuppressingthetypeIinterferonresponsesanddeISGylaseactivitybroadlyremovingISG15conjugatedproteins.Therearecurrentlyabout40knownnairovirusesclassifiedintofourteenspecies.Recentgenomiccharacterizationhasrevealedahighdegreeofdiversity,withvOTUsshowinglessthan25%aminoacidsidentitieswithinthefamily.Previousinvestigationshavebeenlimitedtoonlyafewcloselyrelatednairoviruses,leavingitunclearwhatimpactthisdiversityhasonvOTUfunction.ToprobetheeffectsofvOTUdiversityonenzymeactivityandspecificity,weassessedrepresentativevOTUsspanningtheNairoviridaefamilytowardsUbandISG15fluorogenicsubstrates.Thisrevealedgreatvariationinenzymaticactivityandspecificsubstratepreferences.AsubsetofthevOTUswerefurtherassayedagainsteightbiologicallyrelevantdi-Ubsubstrates,uncoveringbothcommontrendsanddistinctpreferencesofpoly-UblinkagesbyvOTUs.FournovelX-raycrystalstructureswereobtainedthatprovideabiochemicalrationaleforvOTUsubstratepreferencesandelucidatestructuralfeaturesthatdistinguishthevOTUs,includingamotifintheHughesorthonairovirusspeciesthathasnotbeenpreviouslyobservedinOTUdomains.Additionally,structure-informedmutagenesisprovidedthefirstdirectevidenceofasecondsiteinvolvedindi-UbbindingforvOTUs.Theseresultsprovidenewinsightintonairovirusevolutionandpathogenesis,andfurtherenhancesthedevelopmentoftoolsfortherapeuticpurposes.AuthorsummaryVirusesutilizeavarietyofmechanismstomanipulateandsuppresshostresponsestoinfection.Ones

Structural Characteristics of Nairoviruses (Genus Nairovirus, Bunyaviridae) Free. John P. M. Clerx, Jordi Casals and David H. L. Bishop ...1887TogglenavigationToolsTogglenavigationShareJournalofGeneralVirologyVolume55,Issue1ResearchArticleFreeStructuralCharacteristicsofNairoviruses(GenusNairovirus,Bunyaviridae)JohnP.M.Clerx,JordiCasals andDavidH.L.BishopFirstPublished:01July1981https://doi.org/10.1099/0022-1317-55-1-165infoInfoArticleinformationCitedBy(52)MetricslistSectionsAccessfulltextArticlePDFbuildToolsToolsAddtomyfavouritesCreatePublicationAlertCreateCitationAlertCreateCorrectionAlertExportcitationBibTEXEndnoteZoteroRefWorksMendeleyRecommendtolibrary/recommendto/form?webId=%2Fcontent%2Fjournal%2Fjgv&title=Journal+of+General+Virology&issn=0022-1317&eissn=1465-2099JournalofGeneralVirology—RecommendthistitletoyourlibraryReprints&PermissionsshareShareShareAbstractSummaryVirusesfromsixantigenicgroupsofarthropod-borneviruses[Crimean-Congohaemorrhagicfever(CCHF),Nairobisheepdisease(NSD),Qalyub(QYB),Sakhalin(SAK),DeraGhaziKhan(DGK)andHughes(HUG)serogroups],somepreviouslycategorizedasbunyavirus-likevirusesandotherspreviouslyungrouped,haverecentlybeenassembledbyserologicalanalysesintoanewgenusofviruses(Nairovirusgenus)intheBunyaviridae.MolecularstudiesofthevirionRNAandviralpolypeptideshavebeenundertakenwithrepresentativemembersofthedifferentserogroups[Hazara(HAZ)andCongo(CON)viruses,CCHFgroup;Dugbe(DUG)virus,NSDgroup;QYB,OmoandBandia(BDA)viruses,QYBgroup;Avalon(AVA)virus,SAKgroup;DGKandAbuMina(AM)viruses,DGKgroup;andHUGvirus,HUGgroup].InagreementwitharecentstudyofQYBvirusandinpartagreementwithanearlierreportonDUGvirus,theresultsofthesemolecularanalysesindicatethatnairoviruseshave:(i)threevirionRNAspecies(large,L,medium,M,andsmall,S)withapparentmol.wt.of4.1×106to4.9×106,1.5×106to1.9×106and0.6×106to0.7×106respectively;(ii)a48×103to54×103mol.wt.nucleocapsid(N)polypeptide;and(iii)twoexternalglycopolypeptides,72×103to84×103mol.wt.(G1)and30×103to40×103mol.wt.(G2).Cross-immune