Li-Fraumeni Syndrome | li-fraumeni syndrome

Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with high risks for a diverse spectrum of childhood- and ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutNCBIBookshelf.AserviceoftheNationalLibraryofMedicine,NationalInstitutesofHealth.AdamMP,ArdingerHH,PagonRA,etal.,editors.GeneReviews®[Internet].Seattle(WA):UniversityofWashington,Seattle;1993-2021.GeneReviews®[Internet].ShowdetailsAdamMP,ArdingerHH,PagonRA,etal.,editors.Seattle(WA):UniversityofWashington,Seattle;1993-2021.GeneReviewsbyTitleSearchtermGeneReviewsAdvancedSearchHelpLi-FraumeniSyndromeKatherineSchneider,MPH,KristinZelley,MS,KimENichols,MD,andJudyGarber,MD,MPH.AuthorInformationKatherineSchneider,MPHDanaFarberCancerInstituteBoston,MassachusettsEmail:ude.dravrah.icfd@redienhcs_enirehtakKristinZelley,MSChildren'sHospitalofPhiladelphiaPhiladelphia,PennsylvaniaEmail:ude.pohc.liame@kyellezKimENichols,MDStJudeChildren'sResearchHospitalMemphis,TennesseeEmail:[email protected],MD,MPHDanaFarberCancerInstituteBoston,MassachusettsEmail:ude.dravrah.icfd@rebrag_ydujInitialPosting:January19,1999;LastUpdate:November21,2019.Estimatedreadingtime:30minutesSummaryClinicalcharacteristics.Li-Fraumenisyndrome(LFS)isacancerpredispositionsyndromeassociatedwithhighrisksforadiversespectrumofchildhood-andadult-onsetmalignancies.ThelifetimeriskofcancerinindividualswithLFSis≥70%formenand≥90%forwomen.FivecancertypesaccountforthemajorityofLFStumors:adrenocorticalcarcinomas,breastcancer,centralnervoussystemtumors,osteosarcomas,andsoft-tissuesarcomas.LFSisassociatedwithanincreasedriskofseveraladditionalcancersincludingleukemia,lymphoma,gastrointestinalcancers,cancersofheadandneck,kidney,larynx,lung,skin(e.g.,melanoma),ovary,pancreas,prostate,testis,andthyroid.IndividualswithLFSareatincreasedriskforcancerinchildhoodandyoungadulthood;survivorsareatincreasedriskformultipleprimarycancers.Diagnosis/testing.ThediagnosisofLFSisestablishedinaproban

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Li Fraumeni syndrome | li-fraumeni syndrome
Li-Fraumeni syndrome. Disease definition. A rare, inherited, cancer predisposition syndrome characterized by the early-onset of multiple primary cancers including ...
Li-Fraumeni Syndrome | li-fraumeni syndrome
Li-Fraumeni syndrome (LFS) is a classic cancer predisposition disorder that is commonly associated with germline mutations of the p53 tumor suppressor gene.
Li-Fraumeni Syndrome | li-fraumeni syndrome
Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with high risks for a diverse spectrum of childhood- and ...
Li-Fraumeni Syndrome | li-fraumeni syndrome
Li-Fraumeni syndrome (LFS) is an inherited familial predisposition to a wide range of certain, often rare, cancers. This is due to a change (mutation) in a tumor ...
Li-Fraumeni syndrome | li-fraumeni syndrome
Li-Fraumeni syndrome is an inherited autosomal dominant disorder that is manifested by a wide range of malignancies that appear at an unusually early age [1,2]. Li-Fraumeni syndrome is also known as the Sarcoma, Breast, Leukemia, and Adrenal Gland (SBLA) cancer syndrome.
Li-Fraumeni syndrome: MedlinePlus Genetics | li-fraumeni syndrome
Li-Fraumeni Syndrome | li-fraumeni syndrome
Li-Fraumeni Syndrome | li-fraumeni syndrome
Li–Fraumeni syndrome | li-fraumeni syndrome
What is LFS? | li-fraumeni syndrome
Li-Fraumeni syndrome (LFS) is an inherited familial predisposition to a wide range of certain, often rare, cancers. This is due to a change (mutation) in a tumor ...
Li-Fraumeni syndrome: MedlinePlus Genetics | li-fraumeni syndrome
Li-Fraumeni syndrome is a rare disorder that greatly increases the risk of developing several types of cancer, particularly in children and young ...
Li–Fraumeni syndrome | li-fraumeni syndrome
Li–Fraumeni syndrome is a rare, autosomal dominant, hereditary disorder that predisposes carriers to cancer development. It was named after two American ...
Li-Fraumeni Syndrome | li-fraumeni syndrome
What is Li-Fraumeni Syndrome?The Li-Fraumeni Syndrome (LFS) is a hereditary cancer predisposition syndrome first reported in 1969 by Drs. Frederick Li and ...