Li-Fraumeni Syndrome | li-fraumeni syndrome

WhatisLi-Fraumenisyndrome?Li-Fraumenisyndromeisaconditionthatmakesapersonmorelikelytodeveloponeormorecancersintheseareasofthebody:BrainBreastsBonesBloodAdrenalgland(atinyorganthatislocatedontopofeachkidney)MusclesorconnectivetissuesPatientReferralsEmailThisPage RelatedTopicsCancerPredispositionProgramGeneticSyndromesDiseasesTreatedatSt.JudeLesscommonly,peoplewithLi-Fraumenisyndromedevelopothertypesofcancers,includingthoseaffectingtheseareasofthebody:SkinThyroidglandLungsDigestivesystem(esophagus,stomach,pancreasorcolon)Urinarysystem(kidney,bladder)Reproductivesystem(uterus,ovaries,prostate,gonads)WhatcausesLi-Fraumenisyndrome?Li-Fraumenisyndromeiscausedbychangesinageneknownas TP53.Genescarryimportantinformationthattellourbody’scellshowtofunction.The TP53 genecontrolshowcellsgrowanddivide.Oneofitsmainjobsistopreventcancersfromforming.Normally,yourcellscarrytwoworkingcopiesof TP53.Oneisinheritedfromyourmotherandonefromyourfather.CellsfrompeoplewithLi-Fraumenisyndromecarryoneworkingcopyof TP53 andonecopythatisaltered.Thisalterationcausesthegenetonotworkproperlyandiscalledamutation.Whentheremainingworkingcopyof TP53 becomesdamagedwithinacell,thiscanleadtoacancer.DownloadthisSummaryLi-FraumeniResourcesViewvideosfrompatientsandfamilieswhoaremanagingaLi-FraumeniSyndromediagnosis,featuredontogether.stjude.org/lfs.ViewVideosGeneticsHomeReference:Li-FraumeniSyndromeLi-FraumeniSyndromeAssociationLivingLFSAdditionalResourcesMakingSenseofYourGenes:AGuidetoGeneticCounselingYoungPeoplewithCancer:AParent’sGuideWhatisthecancerriskforchildrenwithLi-Fraumenisyndrome?Byage30,itisestimatedthathalfofallpeoplewithLi-Fraumenisyndromewilldevelopsomekindofcancer.Byage60,thelikelihoodofcancerforpeoplewithLi-Fraumenisyndromeincreasestoabout80%–90%.PeoplewithLi-Fraumenisyndromearemorelikelytodevelopmultiplecancersandcancerscausedbyradiation.BecauseofthewiderangeofcancertypesthatcanaffectchildrenwithLi-Fraumenisyndrome,itishardtopredictthekindsofcancerthatwilldevelop.Itisalsohardtoknowwhenthesec

常見健康問答

延伸文章資訊
Li Fraumeni syndrome | li-fraumeni syndrome
Li-Fraumeni syndrome. Disease definition. A rare, inherited, cancer predisposition syndrome characterized by the early-onset of multiple primary cancers including ...
Li-Fraumeni Syndrome | li-fraumeni syndrome
Li-Fraumeni syndrome (LFS) is a classic cancer predisposition disorder that is commonly associated with germline mutations of the p53 tumor suppressor gene.
Li-Fraumeni Syndrome | li-fraumeni syndrome
Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with high risks for a diverse spectrum of childhood- and ...
Li-Fraumeni Syndrome | li-fraumeni syndrome
Li-Fraumeni syndrome (LFS) is an inherited familial predisposition to a wide range of certain, often rare, cancers. This is due to a change (mutation) in a tumor ...
Li-Fraumeni syndrome | li-fraumeni syndrome
Li-Fraumeni syndrome is an inherited autosomal dominant disorder that is manifested by a wide range of malignancies that appear at an unusually early age [1,2]. Li-Fraumeni syndrome is also known as the Sarcoma, Breast, Leukemia, and Adrenal Gland (SBLA) cancer syndrome.
Li-Fraumeni syndrome: MedlinePlus Genetics | li-fraumeni syndrome
Li-Fraumeni Syndrome | li-fraumeni syndrome
Li-Fraumeni Syndrome | li-fraumeni syndrome
Li–Fraumeni syndrome | li-fraumeni syndrome
What is LFS? | li-fraumeni syndrome
Li-Fraumeni syndrome (LFS) is an inherited familial predisposition to a wide range of certain, often rare, cancers. This is due to a change (mutation) in a tumor ...
Li-Fraumeni syndrome: MedlinePlus Genetics | li-fraumeni syndrome
Li-Fraumeni syndrome is a rare disorder that greatly increases the risk of developing several types of cancer, particularly in children and young ...
Li–Fraumeni syndrome | li-fraumeni syndrome
Li–Fraumeni syndrome is a rare, autosomal dominant, hereditary disorder that predisposes carriers to cancer development. It was named after two American ...
Li-Fraumeni Syndrome | li-fraumeni syndrome
What is Li-Fraumeni Syndrome?The Li-Fraumeni Syndrome (LFS) is a hereditary cancer predisposition syndrome first reported in 1969 by Drs. Frederick Li and ...