A Case of Type 2 Hypersensitivity to Rasburicase Diagnosed ... | Type 2 hypersensitivity
Type 2 hypersensitivity reactions (T2HR) are antigen-specific semi-delayed reactions according to Gell and Coombs classification (1).ArticlesLaurentBrossayBrownUniversity,UnitedStatesFranciscoBorregoBiocrucesBizkaiaHealthResearchInstitute,SpainEmilyMaceColumbiaUniversity,UnitedStatesTheeditorandreviewers'affiliationsarethelatestprovidedontheirLoopresearchprofilesandmaynotreflecttheirsituationatthetimeofreview.AbstractEthicsStatementAuthorContributionsConflictofInterestStatementFundingReferencesSuggestaResearchTopic>DownloadArticleDownloadPDFReadCubeEPUBXML(NLM)SupplementaryMaterialExportcitationEndNoteReferenceManagerSimpleTEXTfileBibTextotalviewsViewArticleImpactSuggestaResearchTopic>SHAREONOpenSupplementalDataCASEREPORTarticleFront.Immunol.,29January2018|https://doi.org/10.3389/fimmu.2018.00110ACaseofType2HypersensitivitytoRasburicaseDiagnosedwithaNaturalKillerCellActivationAssaySébastienViel1,2*,RémiPescarmona1,2,AlexandreBelot2,3,AudreyNosbaum2,4,ChristineLombard1,ThierryWalzer2andFrédéricBérard2,4*1Laboratoired’Immunologie,CentreHospitalierLyonSud,HospicesCivilsdeLyon,Lyon,France2CentreInternationaldeRechercheenInfectiologie,CIRI,INSERMU1111,CNRSUMR5308,EcoleNormalesupérieuredeLyon,UniversitéClaudeBernardLyonI,Lyon,France3ServicedeNéphrologie,Rhumatologie,Dermatologiepédiatriques,CNRRAISE,HôpitalFemmeMèreEnfant,HospicesCivilsdeLyon,Bron,France4Serviced’ImmunologieCliniqueetd’Allergologie,CentreHospitalierLyonSud,HospicesCivilsdeLyon,Lyon,FranceDrughypersensitivityreactionscanleadtodifferentclinicalpicturesdependingontheunderlyingimmunologicalmechanism.Diagnosistestsarealreadyavailabletoassessthemostfrequentdrugshypersensitivityreactions,whicharemediatedbyspecificIgEorTcells.However,itremainschallengingtodiagnosetype2hypersensitivityreactions(T2HR),whichcanleadtoseverecytopeniaandliverfailure.Here,wedescribeacaseofT2HRtorasburicase,anuricolyticagentusedtopreventtumorlysissyndrome.Inthispatient,sensitizationwasassociatedwiththeproductionofspecificIgGabletobindtol
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Type 2 hypersensitivityType 4 hypersensitivityHypersensitivityType 1 hypersensitivityType II hypersensitivityType 2 type 3 hypersensitivityType 3 hypersensitivityHypersensitivity type 4