NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutNCBIBookshelf.AserviceoftheNationalLibraryofMedicine,NationalInstitutesofHealth.StatPearls[Internet].TreasureIsland(FL):StatPearlsPublishing;2021Jan-.StatPearls[Internet].ShowdetailsTreasureIsland(FL):StatPearlsPublishing;2021Jan-.SearchtermTypeIIHypersensitivityReactionShammasF.Bajwa;ReemHamdyA.Mohammed.AuthorInformationAuthorsShammasF.Bajwa1;ReemHamdyA.Mohammed.Affiliations1MayoHospitalLahoreLastUpdate:April8,2021.ContinuingEducationActivityTypeIIhypersensitivityreactionisaformofimmune-mediatedreactioninwhichantibodiesaredirectedagainstcellularorextracellularmatrixantigens.Thisantibody-mediatedresponseleadstocellulardestruction,functionalloss,ordamagetotissues.Thisactivitydefinestheinvolvedpathogenicmechanisms,theclinicalpresentations,evaluation,andmanagementofcommonformsoftypeIIhypersensitivityreactionsandhighlightstheroleoftheinterprofessionalteaminthecareofthesepatients.Objectives:DescribetheimmunepathogenesisoftypeIIhypersensitivityreactions.ReviewtheevaluationofthemostcommonformsoftypeIIhypersensitivityreactions.OutlinethevarioustreatmentoptionsforthemostcommonformsoftypeIIhypersensitivityreaction.SummarizetheimportanceofcollaborationandcommunicationamongsttheinterprofessionalteamtoenhancethecareofpatientswithatypeIIhypersensitivityreaction.Earncontinuingeducationcredits(CME/CE)onthistopic.IntroductionTypeIIhypersensitivityreactionreferstoanantibody-mediatedimmunereactioninwhichantibodies(IgGorIgM)aredirectedagainstcellularorextracellularmatrixantigenswiththeresultantcellulardestruction,functionalloss,ordamagetotissues.Damagecanbeaccomplishedvia threedifferentmechanisms:AntibodybindingtocellsurfacereceptorsandalteringitsactivityActivationofthecomplementpathway.[1]Antibodydependantcellularcytotoxicity.[2]EtiologyThetypeIIhypersensitivityimmunereactiondevelopsinresponsetomodificationsofcellsurfaceormatrix-associatedantigensgeneratingantigenicepitopesthatareregardedasf