As one of the largest known intracellular pathogens, T. spiralis is a multi-intracellular parasite of epithelial cells during the intestinal phase of infection.EmbryoseriescourtesyofEinhardSchierenberg HTML  PDForSearchwithTextpressoDownloadPDFversionBiologyandgenomeofTrichinellaspiralis*MakedonkaMitreva§GenomeSequencingCenter,WashingtonUniversitySchoolofMedicine,St.Louis,MO63108USADouglasP.JasmerDepartmentofMolecularMicrobiologyandPathology,CollegeofVeterinaryMedicine,WashingtonStateUniversity,Pullman,WA99164-7040,USAThischapterisinWormBooksection:>Geneticsandgenomics>>Genomics>>>BiologyandgenomeofnematodesotherthanC.elegansView/AddCommentsTableofContents1.Introduction1.1.ThegenusTrichinella1.2.Geographicrange1.3.PhylogeneticpositionofTrichinellawithinthephylumNematoda1.4.Generallifecycle1.5.ZoonoticTransmissionandClinicaldisease2.Molecularandcellularinteractionswiththehost2.1.Entericinfections2.2.Musclecellinfections2.3.Immunologicalinteractions2.4.Parasitemoleculesthatinteractwiththehost3.UseofmolecularbiologyinTrichinella3.1.Diagnostics3.2.Speciesidentification3.3.Proteomics4.PreviousgenomicapplicationstostudyTrichinella5.CurrentgenomesequencingprojectforTrichinellaspiralis6.Acknowledgements7.ReferencesAbstractCladeInematodespeciesinthegenusTrichinellacancauseinfectionsinhumansthatleadtomortalityandseriousmorbidity.Therearecurrentlyeightrecognizedspeciesorgenotypesthatcomprisethisgenus.Thespeciesdisplaydiversebiologicalcharacteristics,theevolutionarysignificanceofwhichrecentlyhasbeenextensivelyclarified.Someofthatdiversitytranslatesintovariableimportanceaszoonoticpathogens,withT.spiralishavingthehighestsignificance.Trichinellosishasre-emergedasanimportantzoonoticinfectioninvariouspartsoftheworld,remindingusthatcontrolofthisinfectiondependsonpersistentvigilance.Trichinellaspeciesdisplayuniqueandbiologicallyinterestingcomplexityininteractionswithhostcellsthattheyinhabit.Significantprogresshasbeenmadetowardunderstandingdetailsoftheseinteractions.Progressontranscrip