Nutritional CNS Disorders | Wernicke's encephalopathy b12

The Wernicke-Korsakoff syndrome (WKS) is a combination of oculomotor ... The common setting of vitamin B12 deficiency is pernicious anemia, an autoimmune ...NEUROPATHOLOGYAnillustratedinteractivecourseformedicalstudentsandresidentsByDimitriP.Agamanolis,M.D.NEUROPATHOLOGYHomeNeuropathologyCourseNeurocytologyHypoxiaandStrokePerinatalDisordersTraumaCNSInfectionsDemyelinatingDiseasesBrainTumorsNutritionalDisordersDegenerativeDiseasesMetabolicDisordersCongenitalMalformationsPeripheralNeuropathyMyopathologyCerebrospinalFluidNeuropathologyTestsNeurocytology(NoTest)HypoxiaandStrokePerinatalDisordersTraumaCNSInfectionsDemyelinatingDiseasesBrainTumorsNutritionalDisordersDegenerativeDiseasesMetabolicDisordersCongenitalMalformationsPeripheralNeuropathyMyopathologyCerebrospinalFluid(NoTest)M2Course&LabsIntroductionLearningObjectivesNEUROPATH-LABLecturesQuiz1Quiz2Quiz3Quiz4Quiz5Quiz6Quiz7Quiz8Quiz9Quiz10Quiz11Quiz12Quiz13Quiz14Quiz15TestAnswersAboutDonateChapter8NUTRITIONALCNSDISORDERSGotopage...TestLearningObjectivesGototopic...TheWernicke-KorsakoffSyndromeMidlineCerebellarDegenerationVitaminEDeficiencyVitaminB12DeficiencySubacuteCombinedDegenerationWERNICKE-KORSAKOFFSYNDROMETheWernicke-Korsakoffsyndrome(WKS)isacombinationofoculomotorabnormalitiesandmentalsymptomsseeninmalnourishedpatientswithvitaminB1(thiamine)deficiency.Itismostcommoninalcoholics,butaffectsalsodementedpeoplewhoneglecttheirnutrition,patientswithgastriccancer,personswhohavehadbariatricsurgery,gastrectomy(sometimesappearingmanyyearsaftertheprocedure),hyperemesisgravidarum,anorexianervosa,andothermalnutritionsettings.TheWKShasalsobeenreportedfollowingtreatmentwithfedratinib,aninhibitorofthiamineuptakeandtransport,andotherchemotherapeuticagents.Thesyndromehas2components:Wernicke�sencephalopathy(WE),andKorsakoff�samnesia(KA).TheclassicclinicalpresentationofWEisatriadofeyeabnormalities(nystagmus,oculomotorparalysis,paralysisofconjugategaze),ataxiaofstanceandgait,andmentalsymptoms,suchaswithdrawalandconfusion.This


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