NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListInVivov.31(1);Jan-Feb2017PMC5354137InVivo.2017Jan-Feb;31(1):121–124.Publishedonline2017Jan5.doi: 10.21873/invivo.11034PMCID:PMC5354137PMID:28064230High-doseParenteralThiamineinTreatmentofWernicke’sEncephalopathy:CaseSeriesandReviewoftheLiteratureANDREWNISHIMOTO,1,2JUSTINUSERY,1,2JOHNC.WINTON,3andJENNIFERTWILLA1,2ANDREWNISHIMOTO1DepartmentofPharmacy,MethodistUniversityHospital,Memphis,TN,U.S.A.2DepartmentofClinicalPharmacy,UniversityofTennessee,Memphis,TN,U.S.A.FindarticlesbyANDREWNISHIMOTOJUSTINUSERY1DepartmentofPharmacy,MethodistUniversityHospital,Memphis,TN,U.S.A.2DepartmentofClinicalPharmacy,UniversityofTennessee,Memphis,TN,U.S.A.FindarticlesbyJUSTINUSERYJOHNC.WINTON3InpatientPhysicians,MethodistGermantownHospital,Memphis,TN,U.S.A.FindarticlesbyJOHNC.WINTONJENNIFERTWILLA1DepartmentofPharmacy,MethodistUniversityHospital,Memphis,TN,U.S.A.2DepartmentofClinicalPharmacy,UniversityofTennessee,Memphis,TN,U.S.A.FindarticlesbyJENNIFERTWILLAAuthorinformationArticlenotesCopyrightandLicenseinformationDisclaimer1DepartmentofPharmacy,MethodistUniversityHospital,Memphis,TN,U.S.A.2DepartmentofClinicalPharmacy,UniversityofTennessee,Memphis,TN,U.S.A.3InpatientPhysicians,MethodistGermantownHospital,Memphis,TN,U.S.A.Dr.JenniferTwilla,Pharm.D.,BCPS.DepartmentofPharmacy,MethodistUniversityHospital,1265UnionAvenue,Memphis,TN,38104,U.S.A.Tel:+19015168170,Fax:[email protected];Accepted2016Dec13.Copyright2017,byTheInternationalInstituteofAnticancerResearchThisarticlehasbeencitedbyotherarticlesinPMC.Background:ThiaminedeficiencycanleadtoWernicke’sencephalopathy(WE),anacuteandpotentiallylife-threateningneurologicaldisorder.EventhoughthemaintreatmentmodalityforWEconsistsofthiaminereplacement,evidencesupportinganoptimaldosingstrategyanddurationisunclear.PatientsandMethods:Wepresentasingle-centercaseseriesofelevenpatientsthatwereadmittedwithpossibleWEandt