The cause of KLS is not known. Several treatments have been used, including stimulant, anti-epileptic, anti-depressant, and anti-psychotic drugs, ...JumptonavigationLanguage:EnglishEspañolFrançaisHrvatskiPolskiРусскийMorelanguagesavailableShowfewerlanguagesCoronavirus(COVID-19)resourcesPharmacologicaltreatmentforKleine-LevinsyndromeBackgroundKleine-Levinsyndrome(KLS)isararedisorderthatmainlyaffectsadolescentmen.Itischaracterisedbyrecurrentepisodesofhypersomnia(excessivesleepiness),hyperphagia(overeating),andabnormalbehaviour.Thefrequencyandnatureoftheattackscandisrupttheindividual'ssocial,professional,andfamilylife.ThecauseofKLSisnotknown.Severaltreatmentshavebeenused,includingstimulant,anti-epileptic,anti-depressant,andanti-psychoticdrugs,withsomebenefitreported,butbecauseoftherarityofthecondition,long-termfollow-upofparticipantsisdifficult.ObjectivesTheauthorsofthisreviewaimedtoidentifyandevaluaterandomisedcontrolledtrials(RCTs)studyingtheeffectivenessofpharmacologicaltreatmentforKleine-Levinsyndrome.ResultsWewerenotabletofindanyRCTs.Good-qualityevidenceisthereforelacking,andtherapeutictrialswithadouble-blind,placebo-controlleddesignareneeded.Theevidencewascurrentto7April2016.Authors'conclusions: TherapeutictrialsofpharmacologicaltreatmentforKleine-Levinsyndromewithadouble-blind,placebo-controlleddesignareneeded.Readthefullabstract...Background: ThisisanupdatedversionoftheoriginalCochranereview,publishedin2009,Issue2.Kleine-Levinsyndrome(KLS)isararedisorderthatmainlyaffectsadolescentmen.Itischaracterisedbyrecurrentepisodesofhypersomnia,usuallyaccompaniedbyhyperphagia,cognitiveandmooddisturbances,abnormalbehaviour,suchashypersexuality,andsignsofdysautonomia.In1990,thediagnosticcriteriaforKleine-LevinsyndromeweremodifiedintheInternationalClassificationofSleepDisorders,whereKLSwasdefinedasasyndromecomprisedofrecurringepisodesofunduesleepinesslastingsomedays,whichmayormaynotbeassociatedwithhyperphagiaandabnormalbehaviour.AccordingtotheInternationalClassificationofSlee