Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumours. These tumours are rare, and they appear when cells in the ...GestationaltrophoblasticdiseaseFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchpregnancy-relatedtumoursGestationaltrophoblasticdiseaseMicrographofintermediatetrophoblast,deciduaandahydatidiformmole(bottomofimage).H&Estain.SpecialtyOncologyGestationaltrophoblasticdisease(GTD)isatermusedforagroupofpregnancy-relatedtumours.Thesetumoursarerare,andtheyappearwhencellsinthewombstarttoproliferateuncontrollably.Thecellsthatformgestationaltrophoblastictumoursarecalledtrophoblastsandcomefromtissuethatgrowstoformtheplacentaduringpregnancy.ThereareseveraldifferenttypesofGTD.Hydatidiformmolesarebenigninmostcases,butsometimesmaydevelopintoinvasivemoles,or,inrarecases,intochoriocarcinoma,whichislikelytospreadquickly,[1][2]butwhichisverysensitivetochemotherapy,andhasaverygoodprognosis.Gestationaltrophoblastsareofparticularinteresttocellbiologistsbecause,likecancer,thesecellsinvadetissue(theuterus),butunlikecancer,theysometimes"know"whentostop.[citationneeded]GTDcansimulatepregnancy,becausetheuterusmaycontainfetaltissue,albeitabnormal.Thistissuemaygrowatthesamerateasanormalpregnancy,andproduceschorionicgonadotropin,ahormonewhichismeasuredtomonitorfetalwell-being.[3]WhileGTDoverwhelminglyaffectswomenofchild-bearingage,itmayrarelyoccurinpostmenopausalwomen.[4]Contents1Types2Cause3Diagnosis3.1Differentialdiagnosis4Treatment4.1Followup5Prognosis5.1Becomingpregnantagain5.2RiskofarepeatGTD5.3Persistenttrophoblasticdisease5.4GTDcoexistingwithanormalfetus,alsocalled"twinpregnancy"6Epidemiology7Terminology8Seealso9References10ExternallinksTypes[edit]GTDisthecommonnameforfivecloselyrelatedtumours(onebenigntumour,andfourmalignanttumours):[5]ThebenigntumourHydatidiformmoleHere,firstafertilisedeggimplantsintotheuterus,butsomecellsaroundthefetus(thechorionicvilli)donotdevelopproperly.Thepregnancyisnotviable,andthenormalpregnancyp