Gestational trophoblastic disease (GTD) is a group of pregnancy-related conditions that develop inside a woman's uterus (womb).YouAreHere:Home→MedicalEncyclopedia→GestationaltrophoblasticdiseaseURLofthispage://medlineplus.gov/ency/article/007333.htmGestationaltrophoblasticdiseaseGestationaltrophoblasticdisease(GTD)isagroupofpregnancy-relatedconditionsthatdevelopinsideawoman'suterus(womb).Theabnormalcellsstartinthetissuethatwouldnormallybecometheplacenta.Theplacentaistheorganthatdevelopsduringpregnancytofeedthefetus.Inmostcases,onlyplacentaltissueformswithgestationaltrophoblasticdisease.Inrarecircumstancesafetusmayalsoform.ThereareseveraltypesofGTD.Choriocarcinoma(atypeofcancer)Hydatiformmole(alsocalledamolarpregnancy)ReferencesBouchard-FortierG,CovensA.Gestationaltrophoblasticdisease:hydatidiformmole,nonmetastaticandmetastaticgestationaltrophoblastictumor:diagnosisandmanagement.In:LoboRA,GershensonDM,LentzGM,ValeaFA,eds.ComprehensiveGynecology.7thed.Philadelphia,PA:Elsevier;2017:chap35.GoldsteinDP,BerkowitzRS,HorowitzNS.Gestationaltrophoblasticdisease.In:NiederhuberJE,ArmitageJO,KastanMB,DoroshowJH,TepperJE,eds.Abeloff'sClinicalOncology.6thed.Philadelphia,PA:Elsevier;2020:chap87.SalaniR,BixelK,CopelandLJ.Malignantdiseasesandpregnancy.In:LandonMB,GalanHL,JauniauxERM,etal,eds.Gabbe'sObstetrics:NormalandProblemPregnancies.8thed.Philadelphia,PA:Elsevier;2021:chap55.ReviewDate3/31/2020Updatedby:JohnD.Jacobson,MD,ProfessorofObstetricsandGynecology,LomaLindaUniversitySchoolofMedicine,LomaLindaCenterforFertility,LomaLinda,CA.AlsoreviewedbyDavidZieve,MD,MHA,MedicalDirector,BrendaConaway,EditorialDirector,andtheA.D.A.M.Editorialteam.MiscarriageReadmoreTumorsandPregnancyReadmoreNIHMedlinePlusMagazineReadmore