ResultsNCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListElsevierSponsoredDocumentsPMC5985369SponsoredDocumentfromInternationalJournalofInfectiousDiseasesIntJInfectDis.2018Jun;71:53–55.doi: 10.1016/j.ijid.2018.03.018PMCID:PMC5985369PMID:29653201KineticsofIgMandIgGantibodiesafterscrubtyphusinfectionandtheclinicalimplicationsGeorgeM.Varghese,⁎VeeraManikandanRajagopal,PaulTrowbridge,DivyaPurushothaman,andSherryJosephMartinAuthorinformationArticlenotesCopyrightandLicenseinformationDisclaimerDepartmentofInfectiousDiseases,ChristianMedicalCollege,Vellore632004,TamilNadu,IndiaGeorgeM.Varghese:moc.liamtoh@esehgravmegroeg⁎Correspondingauthor.moc.liamtoh@esehgravmegroegReceived2017Nov18;Revised2018Mar23;Accepted2018Mar30.Copyright©2018TheAuthor(s)ThisisanopenaccessarticleundertheCCBYlicense(http://creativecommons.org/licenses/by/4.0/).ThisarticlehasbeencitedbyotherarticlesinPMC.ObjectivesTheserologicaldetectionofIgMantibodiesisthemostwidelyusedtesttodiagnosescrubtyphusinfection.However,thekineticsofIgMandIgGantibodiespost-infectionremainelusive,whichcouldcontributetofalsepositivity.Theobjectiveofthisstudywastodocumentthenatureoftheevolutionoftheseantibodytitresafterinfection.MethodsAdultpatientspreviouslyconfirmedtohavescrubtyphusbyIgMELISA,positivePCR,orboth,wereincludedinthiscross-sectionalstudy.ThelevelsofIgMandIgGantibodiesinserumsamplesweretestedusinganELISAandthedistributioncurvewasplotted.ResultsTwohundredandthreepatientswereincludedinthisstudy.Post-infectionserumsamplingwasdonebetween1monthand46monthsafterdocumentedinfection.IgMlevelsdeclinedgraduallybutremainedelevatedabovethediagnosticcut-offforupto12monthspost-infection.However,IgGlevelscontinuedtorisereachingapeakat10months,followedbyagradualdeclineoverseveralmonths.Inthemajorityofcases,theIgGlevelsremainedabovethecut-offthresholdformorethan36months.ConclusionsCliniciansneedtobecautiousinusingasingleserumsamplefort