IMMUNOHISTOCHEMISTRY. Metastatic colorectal adenocarcinomas are most commonly diffusely and strongly positive for CK20 and negative for CK7 (Figures ...

colorectal carcinoma (CRC), although CK7+ or CK20− phenotypes are ... SRCCs were negative for CK7 and strongly positive for CK20.

Keywords: cytokeratin 7, colorectal cancer, polyploidy giant cancer cells, ... Most CRCs show positive IHC staining for CK20 and negative staining for CK7. ... For the CK7 negative group, no tumor cells yielded positive IHC ...

Colorectal adenocarcinoma, the most common tumor that ... CK7-negative, CK20 diffuse positive, CDX2-positive, CEA diffuse positive, ...

Worldwide, colorectal carcinoma (CRC) is associated with significant mortality ... strong CK7 expression and conversely negative CK20 immunoexpression. ... Cells were considered positive for CK20 and CK7 when distinct ...

The CK7 and CK20 expression patterns were different in colorectal ... cell carcinoma most frequently exhibited a K7-negative and K20-positive ...

Coordinate CK7/CK20 expression profiles have been extensively studied in a ... The CK7−/CK20+ profile is known to be highly characteristic of colorectal cancer ... 156 PDAs, 50 (32.1%) were positive and 106 (67.9%) were negative for CK7, ...

According to several studies the multi-marker phenotype CK20+/CK7− is observed in colorectal cancer in approximately 75–95%2, 14 of cases whereas the multi-marker phenotype CK20−/CK7+ favors primary tumors of the lung, breast, biliary tract, pancreas, ovary and endometrium.

However, CDX2 expression was also found in gastric carcinoma, and ... For negative control samples, the primary antibody was omitted for each run. ... Among the CK7-/CK20- colorectal tumors CDX2 was positive in 16 of 17 ...

Bayrak et al. reported that a CK7-positive/CK20-negative expression pattern was observed in only 1.7 % (2 of 118) of colorectal carcinomas [10].