The CK7 and CK20 expression patterns were different in colorectal ... cell carcinoma most frequently exhibited a K7-negative and K20-positive ...ArticleCytokeratin7andCytokeratin20expressionincolorectaladenocarcinomaMarch2011Pathology-ResearchandPractice207(3):156-60DOI:10.1016/j.prp.2010.12.005SourcePubMedAuthors:ReyhanBayrakIstanbulAydinUniversitySibelYenidünyaSibelYenidünyaThispersonisnotonResearchGate,orhasn'tclaimedthisresearchyet.HacerHaltaşFatihUniversityRequestfull-textPDFToreadthefull-textofthisresearch,youcanrequestacopydirectlyfromtheauthors.Requestfull-textDownloadcitationCopylinkLinkcopiedRequestfull-textDownloadcitationCopylinkLinkcopiedToreadthefull-textofthisresearch,youcanrequestacopydirectlyfromtheauthors.Citations(75)References(26)AbstractCytokeratin7(CK7)andcytokeratin20(CK20)arelowmolecularweightcytokeratins.TheexpressionsofCK7andCK20havebeenstudiedinvariousprimaryandmetastaticcarcinomas.Theirexpressionpatternsmayhelptodistinguishthesiteoforiginofmetastaticcarcinomas.WeinvestigatedtheexpressionsofCK7andCK20in196casesofcolorectalcarcinoma.Paraffinsectionsof196colonicadenocarcinomaswererandomlyselected,retrieved,andimmunostainedforCK7andCK20withastandardavidin-biotincomplexmethod.CK7wasexpressedin34/196(17.3%)andCK20in159/196(81.1)casesofcolorectaladenocarcinoma.CK7-/CK20+hadthegreatestproportion(65.8%)incolorectalcarcinomas.TheCK7+/CK20+immunophenotypewasidentifiedin30/196(15.3%),CK7-/CK20-in33/196(16.9%),andCK7+/CK20-in4/196(2%)colonadenocarcinomas.TheCK7andCK20expressionpatternsweredifferentincolorectalcarcinomasaccordingtohistologicalgrade,locationofthetumor,andlymphnodemetastasis.CK20positivitywasmorecommoninlowgradecarcinomasthaninhighgradecarcinomas(85.1%versus47.6%)andinrectalandsigmoidcarcinomasthaninproximalcoloncarcinomas(88.2%versus63.2%and88.9%versus63.2%,respectively).Furthermore,CK7expressionwasmorecommonintumorswithlymphnodemetastasisthaninnon-metastatictumors(25.3%versus11%).Inconclusion,aconsiderablenumberofcolorectalcarcinomassh