Worldwide, colorectal carcinoma (CRC) is associated with significant mortality ... strong CK7 expression and conversely negative CK20 immunoexpression. ... Cells were considered positive for CK20 and CK7 when distinct ...HomeAboutusInstructionsSubmissionSubscribeAdvertiseContactLogin    CurrentIssuePastIssuesAheadofPrintSearchUsersOnline: 271    ORIGINALARTICLE Year:2018 | Volume:24 | Issue:2 | Page:129-134Immunohistochemicalstainingofcytokeratin20andcytokeratin7incolorectalcarcinomas:FourdifferentimmunostainingprofilesJaudahAl-Maghrabi1,EmanEmam2,WafaeyGomaa31 DepartmentofPathology,FacultyofMedicine,KingAbdulazizUniversity,Jeddah,SaudiArabia2 DepartmentofPathology,FacultyofMedicine,KingAbdulazizUniversity,Jeddah,SaudiArabia;DepartmentofPathology,FacultyofMedicine,AlexandriaUniversity,Alexandria,Egypt3 DepartmentofPathology,FacultyofMedicine,KingAbdulazizUniversity,Jeddah,SaudiArabia;DepartmentofPathology,FacultyofMedicine,MiniaUniversity,Al-Minia,EgyptClickhereforcorrespondenceaddressandemailDateofWebPublication6-Apr-2018    Abstract Background/Aim:AberrantexpressionofCK20/CK7isreportedinapercentageofcolorectalcarcinomas(CRC);however,itsrelationtoclinicopathologicalvariablesandsurvivaldataisstillunclear.TheobjectiveofthisstudyistoexplorepatternsofCK20/CK7immunostaininginCRCandtoanalysethediagnostic,prognostic,andpredictiveroleofpatternsofCK20/CK7immunostaining.MaterialsandMethods:Atotalof144CRCcaseswereretrievedfromthearchivesattheDepartmentofPathology,KingAbdulazizUniversity,Jeddah,SaudiArabia.ImmunohistochemistrywasperformedusingantibodytoCK7andCK20.Immunostainingwasdefinedaslowandhighbyusingtheextentofstaining.TheassociationofCK7andCK20withclinicopathologicalcharacteristicsandsurvival.Results:CK20wasexpressedinahigherpercentageofCRCandnodalmetastasisthanCK7.NodifferenceinCK7andCK20immunostaininginprimaryandmetastasiscarcinomaswasfound.FourpatternsofCK20/CK7wereidentified;CK20+/CK7−(60.4%),CK20+/CK7+(2.1%),CK20−/CK7−(35.4%),andCK20−/CK7+(2.1%).Therewasnostatistic

colorectal carcinoma (CRC), although CK7+ or CK20− phenotypes are ... SRCCs were negative for CK7 and strongly positive for CK20.SkiptoMainContentJournallistmenuJournalArticlesActionsToolsFollowjournalCookiesdisabledCookiesaredisabledforthisbrowser.WileyOnlineLibraryrequirescookiesforauthenticationanduseofothersitefeatures;therefore,cookiesmustbeenabledtobrowsethesite.DetailedinformationonhowWileyusescookiescanbefoundinourPrivacyPolicy.LogintoWileyOnlineLibraryEmailorCustomerIDPasswordForgotpassword?NEWUSER>INSTITUTIONALLOGIN>ChangePasswordOldPasswordNewPasswordTooShortWeakMediumStrongVeryStrongTooLongPasswordChangedSuccessfullyYourpasswordhasbeenchangedCreateanewaccountEmailorCustomerIDReturninguserForgotyourpassword?Enteryouremailaddressbelow.EmailorCustomerIDPleasecheckyouremailforinstructionsonresettingyourpassword.Ifyoudonotreceiveanemailwithin10minutes,youremailaddressmaynotberegistered,andyoumayneedtocreateanewWileyOnlineLibraryaccount.RequestUsernameCan'tsignin?Forgotyourusername?EnteryouremailaddressbelowandwewillsendyouyourusernameEmailorCustomerIDCloseIftheaddressmatchesanexistingaccountyouwillreceiveanemailwithinstructionstoretrieveyourusername

NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListThoracCancerv.6(3);2015MayPMC4448377ThoracCancer.2015May;6(3):288–295.Publishedonline2015Apr24.doi: 10.1111/1759-7714.12181PMCID:PMC4448377PMID:26273374Expressionofp63andCK5/6inearly-stagelungsquamouscellcarcinomaisnotonlyanearlydiagnosticindicatorbutalsocorrelateswithagoodprognosisYunfanMa,1MengyingFan,1LiangDai,1XiaozhengKang,1YiqiangLiu,2YuSun,2HongchaoXiong,1ZhenLiang,1WanpuYan,1andKenengChen1YunfanMa1KeyLaboratoryofCarcinogenesisandTranslationalResearch(MinistryofEducation),TheFirstDepartmentofThoracicSurgery,PekingUniversityCancerHospital&Institute,Beijing,ChinaFindarticlesbyYunfanMaMengyingFan1KeyLaboratoryofCarcinogenesisandTranslationalResearch(MinistryofEducation),TheFirstDepartmentofThoracicSurgery,PekingUniversityCancerHospital&Institute,Beijing,ChinaFindarticlesbyMengyingFanLiangDai1KeyLaboratoryofCarcinogenesisandTranslationalResearch(MinistryofEducation),TheFirstDepartmentofThoracicSurgery,PekingUniversityCancerHospital&Institute,Beijing,ChinaFindarticlesbyLiangDaiXiaozhengKang1KeyLaboratoryofCarcinogenesisandTranslationalResearch(MinistryofEducation),TheFirstDepartmentofThoracicSurgery,PekingUniversityCancerHospital&Institute,Beijing,ChinaFindarticlesbyXiaozhengKangYiqiangLiu2DepartmentofPathology,PekingUniversityCancerHospital&Institute,Beijing,ChinaFindarticlesbyYiqiangLiuYuSun2DepartmentofPathology,PekingUniversityCancerHospital&Institute,Beijing,ChinaFindarticlesbyYuSunHongchaoXiong1KeyLaboratoryofCarcinogenesisandTranslationalResearch(MinistryofEducation),TheFirstDepartmentofThoracicSurgery,PekingUniversityCancerHospital&Institute,Beijing,ChinaFindarticlesbyHongchaoXiongZhenLiang1KeyLaboratoryofCarcinogenesisandTranslationalResearch(MinistryofEducation),TheFirstDepartmentofThoracicSurgery,PekingUniversityCancerHospital&Institute,Beijing,ChinaFindarticlesbyZhenLiangWanpuYan1KeyLaboratoryofCarcinogenesisandTranslationalResearch(MinistryofEduca

Skiptomaincontent Colon-InvasivecarcinomaEmailPrintHome>Colon-InvasivecarcinomaUNDERSTANDINGYOURPATHOLOGYREPORT: AFAQSHEET Whenyourcolonwasbiopsiedorresected,thesamplestakenwerestudiedunderthemicroscopebyaspecializeddoctorwithmanyyearsoftrainingcalledapathologist. Thepathologyreporttellsyourtreatingdoctorthediagnosisineachofthesamplestohelpmanageyourcare. ThisFAQsheetisdesignedtohelpyouunderstandthemedicallanguageusedinthepathologyreport.Thecolonispartofthegastrointestinalsystemthatprocessesfoodtosothatthepartsthatcanbeusedforenergyandbodybuildingcanbeabsorbedintothebodyandused.Thecolon'sjobistoabsorbwateroutoftheleftoverfoodaswellasthelastfewbitsofnutrients.Italsostorestheleftoverfood,calledfeces,untilitisconvenientforthebodytogetridofit.Thecolonislargeandissometimesknownasthe"large"bowel.Itstartsonthelowerrighthandsideoftheabdomenandmakesalmostacompletecirclealongtheedgeoftheabdomen.Wastefoodisliquidwhenitentersthecolon.Asitispushedthroughthecolonbythemusclesinthewallofthecolon,wateristakenoutofthewasteandthewastebecomesmoresolid.1. Whatifmyreportmentions"cecum","ascendingcolon","transversecolon","descendingcolon","sigmoidcolon",or"rectum"?Thecolonisdividedintodifferentpartsbyphysicianstohelplocatewherealesionis.Thececumisthebeginningofthecolonwherethesmallintestineemptiesintothelargeintestine. Theascendingcolonisnextandgoesupalongtherightsideoftheabdomen.Next,thetransversecoloncrossesovertotheleftsideunderthestomachandliverandbecomesthedescendingcolonwhichgoesdownalongtheleftsideoftheabdomen.Thesigmoidcolonislastandisinthebottomoftheabdomen.Thesigmoidcolonisconnectedtotheanusbytheshortestpartofthecoloncalledtherectum.Thefecesorwastefoodexitsthebodythroughtheanus.2. Whatisnormallypresentinthecolon?Thecolonhasalining,calledmucosa,whichismadeupofcolumnarcellsthatformtubes,calledcrypts.Thecolumnarcellsarecalledcolumnarbecausetheyaremuchtallerthantheyarewide.Thecolumnarcellsinthecolonarearrangedincryptswhichlooklikelongpocketsortubes.Thecellsofthemucosamakemucin,which

The CK7 and CK20 expression patterns were different in colorectal ... cell carcinoma most frequently exhibited a K7-negative and K20-positive ...ArticleCytokeratin7andCytokeratin20expressionincolorectaladenocarcinomaMarch2011Pathology-ResearchandPractice207(3):156-60DOI:10.1016/j.prp.2010.12.005SourcePubMedAuthors:ReyhanBayrakIstanbulAydinUniversitySibelYenidünyaSibelYenidünyaThispersonisnotonResearchGate,orhasn'tclaimedthisresearchyet.HacerHaltaşFatihUniversityRequestfull-textPDFToreadthefull-textofthisresearch,youcanrequestacopydirectlyfromtheauthors.Requestfull-textDownloadcitationCopylinkLinkcopiedRequestfull-textDownloadcitationCopylinkLinkcopiedToreadthefull-textofthisresearch,youcanrequestacopydirectlyfromtheauthors.Citations(75)References(26)AbstractCytokeratin7(CK7)andcytokeratin20(CK20)arelowmolecularweightcytokeratins.TheexpressionsofCK7andCK20havebeenstudiedinvariousprimaryandmetastaticcarcinomas.Theirexpressionpatternsmayhelptodistinguishthesiteoforiginofmetastaticcarcinomas.WeinvestigatedtheexpressionsofCK7andCK20in196casesofcolorectalcarcinoma.Paraffinsectionsof196colonicadenocarcinomaswererandomlyselected,retrieved,andimmunostainedforCK7andCK20withastandardavidin-biotincomplexmethod.CK7wasexpressedin34/196(17.3%)andCK20in159/196(81.1)casesofcolorectaladenocarcinoma.CK7-/CK20+hadthegreatestproportion(65.8%)incolorectalcarcinomas.TheCK7+/CK20+immunophenotypewasidentifiedin30/196(15.3%),CK7-/CK20-in33/196(16.9%),andCK7+/CK20-in4/196(2%)colonadenocarcinomas.TheCK7andCK20expressionpatternsweredifferentincolorectalcarcinomasaccordingtohistologicalgrade,locationofthetumor,andlymphnodemetastasis.CK20positivitywasmorecommoninlowgradecarcinomasthaninhighgradecarcinomas(85.1%versus47.6%)andinrectalandsigmoidcarcinomasthaninproximalcoloncarcinomas(88.2%versus63.2%and88.9%versus63.2%,respectively).Furthermore,CK7expressionwasmorecommonintumorswithlymphnodemetastasisthaninnon-metastatictumors(25.3%versus11%).Inconclusion,aconsiderablenumberofcolorectalcarcinomassh

Keywords: cytokeratin 7, colorectal cancer, polyploidy giant cancer cells, ... Most CRCs show positive IHC staining for CK20 and negative staining for CK7. ... For the CK7 negative group, no tumor cells yielded positive IHC ...JournalofCancerImpactfactor3.565ISSN:1837-9664 HomeEditorialboardAboutthisjournalAuthorinfoSubmitmanuscriptManuscriptloginContactCurrentissueVolume12,2021Volume11,2020AdvancearticlesArchiveVolume10,2019Volume9,2018Volume8,2017Volume7,2016Volume6,2015Volume5,2014Volume4,2013Volume3,2012Volume2,2011Volume1,2010CoverimagesSpecialissuesInternationalJournalofBiologicalSciencesInternationalJournalofMedicalSciencesTheranosticsJournalofGenomicsNanotheranosticsTopIntroductionMaterialsandMethodsResultsDiscussionConclusionAbbreviationsAcknowledgementsReferencesGlobalreach,higherimpactEnteryoursearchtermswww.jcancer.orgSubmitsearchform PDFJCancer2019;10(11):2510-2519.doi:10.7150/jca.29397ResearchPaperCK7expressionassociateswiththelocation,differentiation,lymphnodemetastasis,andtheDukes'stageofprimarycolorectalcancersFeiFei1,2#,ChunyuanLi1,2#,YuanCao2#,KaiLiu3,JiaxingDu4,YanjunGu5,XinluWang4,YuweiLi6,ShiwuZhang1,21.NankaiUniversitySchoolofMedicine,NankaiUniversity,Tianjin,P.R.China.2.DepartmentofPathology,TianjinUnionMedicalCenter,Tianjin,P.R.China.3.TianjinMedicalUniversity,Tianjin,P.R.China4.GraduateSchool,TianjinUniversityofTraditionalChineseMedicine,Tianjin,P.R.China5.Departmentofpathology,AffiliatedHospitalofLogisticUniversityofPeople'sArmedPoliceForce,Tianjin,P.R.China.6.Departmentsofcolorectalsurgery,TianjinUnionMedicalCenter,Tianjin,P.R.China#Theseauthorsequallycontributedtothepaper.ThisisanopenaccessarticledistributedunderthetermsoftheCreativeCommonsAttribution(CCBY-NC)license(https://creativecommons.org/licenses/by-nc/4.0/).Seehttp://ivyspring.com/termsforfulltermsandconditions.Citation:FeiF,LiC,CaoY,LiuK,DuJ,GuY,WangX,LiY,ZhangS.CK7expressionassociateswiththelocation,differentiation,lymphnodemetastasis,andtheDukes'stageofprimarycolorectalcancers

Colorectal adenocarcinoma, the most common tumor that ... CK7-negative, CK20 diffuse positive, CDX2-positive, CEA diffuse positive, ...SkiptoMainContentAdvertisementSearchMenuAccountMenuMenuSignInRegisterNavbarSearchFilterThisissueAllJapaneseJournalofClinicalOncologyAllJournalsMobileMicrositeSearchTermSearchSignInRegisterIssuesAdvancearticlesSubmitAuthorGuidelinesSubmissionSiteOpenAccessPurchaseAlertsAboutAboutJapaneseJournalofClinicalOncologyEditorialBoardReviewerBoardAdvertisingandCorporateServicesJournalsCareerNetworkSelf-ArchivingPolicyDispatchDatesIssuesAdvancearticlesSubmitAuthorGuidelinesSubmissionSiteOpenAccessPurchaseAlertsAboutAboutJapaneseJournalofClinicalOncologyEditorialBoardReviewerBoardAdvertisingandCorporateServicesJournalsCareerNetworkSelf-ArchivingPolicyDispatchDatesClosesearchfilterThisissueAllJapaneseJournalofClinicalOncologyAllJournalssearchinputSearchAdvancedSearchSearchMenuSkipNavDestinationArticleNavigationClosemobilesearchnavigationArticleNavigationVolume40Issue3March2010ArticleContentsAbstractINTRODUCTIONPATIENTSANDMETHODSRESULTSDISCUSSIONConflictofintereststatementReferencesArticleNavigationCK7,CK20,CDX2andMUC2ImmunohistochemicalStainingUsedToDistinguishMetastaticColorectalCarcinomaInvolvingOvaryfromPrimaryOvarianMucinousAdenocarcinomaJungHaShin,JungHaShin1DepartmentofHospitalPathology,CollegeofMedicine,TheCatholicUniversityofKoreaSearchforotherworksbythisauthoron:OxfordAcademicPubMedGoogleScholarJeongHoonBae,JeongHoonBae2DepartmentofObstetricsandGynecology,CollegeofMedicine,TheCatholicUniversityofKoreaSearchforotherworksbythisauthoron:OxfordAcademicPubMedGoogleScholarAhwonLee,AhwonLee1DepartmentofHospitalPathology,CollegeofMedicine,TheCatholicUniversityofKoreaForreprintsandallcorrespondence:AhwonLee,DepartmentofHospitalPathology,CollegeofMedicine,TheCatholicUniversityofKorea,KangnamStMary'sHospital,#505Banpo-dong,Seocho-gu,Seoul137-040,RepublicofKorea.E-mail:[email protected]:OxfordAcademic