Worldwide, colorectal carcinoma (CRC) is associated with significant mortality ... strong CK7 expression and conversely negative CK20 immunoexpression. ... Cells were considered positive for CK20 and CK7 when distinct ...HomeAboutusInstructionsSubmissionSubscribeAdvertiseContactLogin    CurrentIssuePastIssuesAheadofPrintSearchUsersOnline: 271    ORIGINALARTICLE Year:2018 | Volume:24 | Issue:2 | Page:129-134Immunohistochemicalstainingofcytokeratin20andcytokeratin7incolorectalcarcinomas:FourdifferentimmunostainingprofilesJaudahAl-Maghrabi1,EmanEmam2,WafaeyGomaa31 DepartmentofPathology,FacultyofMedicine,KingAbdulazizUniversity,Jeddah,SaudiArabia2 DepartmentofPathology,FacultyofMedicine,KingAbdulazizUniversity,Jeddah,SaudiArabia;DepartmentofPathology,FacultyofMedicine,AlexandriaUniversity,Alexandria,Egypt3 DepartmentofPathology,FacultyofMedicine,KingAbdulazizUniversity,Jeddah,SaudiArabia;DepartmentofPathology,FacultyofMedicine,MiniaUniversity,Al-Minia,EgyptClickhereforcorrespondenceaddressandemailDateofWebPublication6-Apr-2018    Abstract Background/Aim:AberrantexpressionofCK20/CK7isreportedinapercentageofcolorectalcarcinomas(CRC);however,itsrelationtoclinicopathologicalvariablesandsurvivaldataisstillunclear.TheobjectiveofthisstudyistoexplorepatternsofCK20/CK7immunostaininginCRCandtoanalysethediagnostic,prognostic,andpredictiveroleofpatternsofCK20/CK7immunostaining.MaterialsandMethods:Atotalof144CRCcaseswereretrievedfromthearchivesattheDepartmentofPathology,KingAbdulazizUniversity,Jeddah,SaudiArabia.ImmunohistochemistrywasperformedusingantibodytoCK7andCK20.Immunostainingwasdefinedaslowandhighbyusingtheextentofstaining.TheassociationofCK7andCK20withclinicopathologicalcharacteristicsandsurvival.Results:CK20wasexpressedinahigherpercentageofCRCandnodalmetastasisthanCK7.NodifferenceinCK7andCK20immunostaininginprimaryandmetastasiscarcinomaswasfound.FourpatternsofCK20/CK7wereidentified;CK20+/CK7−(60.4%),CK20+/CK7+(2.1%),CK20−/CK7−(35.4%),andCK20−/CK7+(2.1%).Therewasnostatistic